Search Results - "Gelhaus, Stacy"

G Protein-Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action by Wendell, Stacy Gelhaus, Fan, Hao, Zhang, Cheng

“…Asthma is a heterogeneous inflammatory disease of the airways that is associated with airway hyperresponsiveness and airflow limitation. Although asthma was…”
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Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment by Bender, Mackenzie J., McPherson, Alex C., Phelps, Catherine M., Pandey, Surya P., Laughlin, Colin R., Shapira, Jake H., Medina Sanchez, Luzmariel, Rana, Mohit, Richie, Tanner G., Mims, Tahliyah S., Gocher-Demske, Angela M., Cervantes-Barragan, Luisa, Mullett, Steven J., Gelhaus, Stacy L., Bruno, Tullia C., Cannon, Nikki, McCulloch, John A., Vignali, Dario A.A., Hinterleitner, Reinhard, Joglekar, Alok V., Pierre, Joseph F., Lee, Sonny T.M., Davar, Diwakar, Zarour, Hassane M., Meisel, Marlies

“…The use of probiotics by cancer patients is increasing, including among those undergoing immune checkpoint inhibitor (ICI) treatment. Here, we elucidate a…”
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Fatty acids, inflammation, and asthma by Wendell, Stacy Gelhaus, PhD, Baffi, Cindy, MD, Holguin, Fernando, MD, MPH

“…Fatty acids and consequently diet play an essential role in the formation of inflammatory mediators involved in the pathogenesis of asthma. Because intake…”
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Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions by Menk, Ashley V., Scharping, Nicole E., Moreci, Rebecca S., Zeng, Xue, Guy, Cliff, Salvatore, Sonia, Bae, Heekyong, Xie, Jianxin, Young, Howard A., Wendell, Stacy Gelhaus, Delgoffe, Greg M.

“…To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process common to highly proliferative cells in which glucose is fermented…”
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Prostaglandin D2 pathway upregulation: Relation to asthma severity, control, and TH2 inflammation by Fajt, Merritt L., Gelhaus, Stacy L., Freeman, Bruce, Uvalle, Crystal E., Trudeau, John B., Holguin, Fernando, Wenzel, Sally E.

“…Bronchoalveolar lavage (BAL) fluid prostaglandin D2 (PGD2) levels are increased in patients with severe, poorly controlled asthma in association with…”
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Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids by Delmastro-Greenwood, Meghan, Freeman, Bruce A, Wendell, Stacy Gelhaus

“…Unsaturated fatty acids are metabolized to reactive products that can act as pro- or anti-inflammatory signaling mediators. Electrophilic fatty acid species,…”
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Nitrated fatty acids: synthesis and measurement by Woodcock, Steven R., Bonacci, Gustavo, Gelhaus, Stacy L., Schopfer, Francisco J.

“…Nitrated fatty acids are the product of nitrogen dioxide reaction with unsaturated fatty acids. The discovery of peroxynitrite and peroxidase-induced nitration…”
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Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples by O’Donnell, Valerie B., Schebb, Nils H., Milne, Ginger L., Murphy, Michael P., Thomas, Christopher P., Steinhilber, Dieter, Gelhaus, Stacy L., Kühn, Hartmut, Gelb, Michael H., Jakobsson, Per-Johan, Blair, Ian A., Murphy, Robert C., Freeman, Bruce A., Brash, Alan R., FitzGerald, Garret A.

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Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling by Koudelka, Adolf, Buchan, Gregory J., Cechova, Veronika, O’Brien, James P., Stevenson, Emily R., Uvalle, Crystal E., Liu, Heng, Woodcock, Steven R., Mullett, Steven J., Zhang, Cheng, Freeman, Bruce A., Gelhaus, Stacy L.

“…The enzymatic oxidation of arachidonic acid is proposed to yield trihydroxytetraene species (termed lipoxins) that resolve inflammation via ligand activation…”
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Liraglutide Protects Against Diastolic Dysfunction and Improves Ventricular Protein Translation by Rutledge, Cody, Enriquez, Angela, Redding, Kevin, Lopez, Mabel, Mullett, Steven, Gelhaus, Stacy L, Jurczak, Michael, Goetzman, Eric, Kaufman, Brett A

“…Diastolic dysfunction is an increasingly common cardiac pathology linked to heart failure with preserved ejection fraction. Previous studies have implicated…”
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Sex-based differences in persistent lung inflammation following influenza infection of juvenile outbred mice by Huckestein, Brydie R, Antos, Danielle, Manni, Michelle L, Zeng, Kelly, Miller, Leigh M, Parenteau, Kristen L, Gelhaus, Stacy L, Mullett, Steven J, Shoemaker, Jason E, Alcorn, John F

“…Children are susceptible to influenza infections and can experience severe disease presentation due to a lack of or limited pre-existing immunity. Despite the…”
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Dietary dicarboxylic acids provide a nonstorable alternative fat source that protects mice against obesity by Goetzman, Eric S, Zhang, Bob B, Zhang, Yuxun, Bharathi, Sivakama S, Bons, Joanna, Rose, Jacob, Shah, Samah, Solo, Keaton J, Schmidt, Alexandra V, Rao, Krithika S, Shiva, Sruti S, Pfister, Katherine E, Barbosa, Anne Silva, Sims-Lucas, Sunder, Dobrowolski, Steven F, Schilling, Birgit, Richert, Adam C, Mullet, Steven J, Gelhaus, Stacy L

“…Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid m-oxidation. The effects of consuming dicarboxylic fatty…”
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Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression by Javed, Zaineb, Shin, Dong Hui, Pan, Weihua, White, Sierra R, Elhaw, Amal Taher, Kim, Yeon Soo, Kamlapurkar, Shriya, Cheng, Ya-Yun, Benson, J Cory, Abdelnaby, Ahmed Emam, Phaëton, Rébécca, Wang, Hong-Gang, Yang, Shengyu, Sullivan, Mara L G, St.Croix, Claudette M, Watkins, Simon C, Mullett, Steven J, Gelhaus, Stacy L, Lee, Nam, Coffman, Lan G, Aird, Katherine M, Trebak, Mohamed, Mythreye, Karthikeyan, Walter, Vonn, Hempel, Nadine

“…Aberrant mitochondrial fission/fusion dynamics are frequently associated with pathologies, including cancer. We show that alternative splice variants of the…”
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The gut protist Tritrichomonas arnold restrains virus-mediated loss of oral tolerance by modulating dietary antigen-presenting dendritic cells by Medina Sanchez, Luzmariel, Siller, Magdalena, Zeng, Yanlin, Brigleb, Pamela H, Sangani, Kishan A, Soto, Ariadna S, Engl, Clarisse, Laughlin, Colin R, Rana, Mohit, Van Der Kraak, Lauren, Pandey, Surya P, Bender, Mackenzie J, Fitzgerald, Britney, Hedden, Lee, Fiske, Kay, Taylor, Gwen M, Wright, Austin P, Mehta, Isha D, Rahman, Syed A, Galipeau, Heather J, Mullett, Steven J, Gelhaus, Stacy L, Watkins, Simon C, Bercik, Premysl, Nice, Timothy J, Jabri, Bana, Meisel, Marlies, Das, Jishnu, Dermody, Terence S, Verdú, Elena F, Hinterleitner, Reinhard

“…Loss of oral tolerance (LOT) to gluten, driven by dendritic cell (DC) priming of gluten-specific T helper 1 (Th1) cell immune responses, is a hallmark of…”
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Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis by Bakalov, Veli, Reyes-Uribe, Laura, Deshpande, Rahul, Maloy, Abigail L, Shapiro, Steven D, Angus, Derek C, Chang, Chung-Chou H, Le Moyec, Laurence, Wendell, Stacy Gelhaus, Kaynar, Ata Murat

“…Sepsis is the leading cause of death in hospitalized patients and beyond the hospital stay and these long-term sequelae are due in part to unresolved…”
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Nitro-fatty acid formation and metabolism by Buchan, Gregory J., Bonacci, Gustavo, Fazzari, Marco, Salvatore, Sonia R., Gelhaus Wendell, Stacy

“…Nitro-fatty acids (NO2-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in…”
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Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma by Heinrich, Victoria A, Uvalle, Crystal, Manni, Michelle L, Li, Kelvin, Mullett, Steven J, Donepudi, Sri Ramya, Clader, Jason, Fitch, Adam, Ellgass, Madeline, Cechova, Veronika, Qin, Shulin, Holguin, Fernando, Freeman, Bruce A, Methé, Barbara A, Morris, Alison, Gelhaus, Stacy L

“…Obesity and associated changes to the gut microbiome worsen airway inflammation and hyperresponsiveness in asthma. Obesogenic host-microbial metabolomes have…”
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Regulation of Benzo[a]pyrene-Mediated DNA- and Glutathione-Adduct Formation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Human Lung Cells by Gelhaus, Stacy L, Harvey, Ronald G, Penning, Trevor M, Blair, Ian A

“…Environmental carcinogens, such as polycyclic aromatic hydrocarbons (PAHs), require metabolic activation to DNA-reactive metabolites in order to exert their…”
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A Prospective Cohort Protocol for the Remnant Investigation in Sepsis Study by Seymour, Christopher W, Urbanek, Kelly Lynn, Nakayama, Anna, Kennedy, Jason N, Powell, Rachel, Robinson, Renã A S, Kapp, Kathryn L, Billiar, Timothy R, Vodovotz, Yoram, Gelhaus, Stacy L, Cooper, Vaughn S, Tang, Lu, Mayr, Flo, Reitz, Katherine M, Horvat, Christopher, Meyer, Nuala J, Dickson, Robert P, Angus, Derek, Palmer, Octavia Peck

“…Sepsis is a common and deadly syndrome, accounting for more than 11 million deaths annually. To mature a deeper understanding of the host and pathogen…”
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Metabolism of Benzo[a]pyrene in Human Bronchoalveolar H358 Cells Using Liquid Chromatography–Mass Spectrometry by Jiang, Hao, Gelhaus, Stacy L, Mangal, Dipti, Harvey, Ronald G, Blair, Ian A, Penning, Trevor M

“…Benzo[a]pyrene (B[a]P), a representative polycyclic aromatic hydrocarbon (PAH), is metabolically activated by three enzymatic pathways: by peroxidases (e.g.,…”
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