Search Results - "Gelfand, Erwin W"

Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma by Gelfand, Erwin W.

“…For several decades, the leukotriene pathways have been implicated as playing a central role in the pathophysiology of asthma. The presence and elevation of…”
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The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines by Thurmond, Robin L., Gelfand, Erwin W., Dunford, Paul J.

“…Key Points There are four known receptors for histamine. Antagonists for H 1 and H 2 receptors are currently in clinical use for the treatment of allergies,…”
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The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma by GOLEVA, Elena, JACKSON, Leisa P, KIRK HARRIS, J, ROBERTSON, Charles E, RAND SUTHERLAND, E, HALL, Clifton F, GOOD, James T, GELFAND, Erwin W, MARTIN, Richard J, LEUNG, Donald Y. M

“…The role of airway microbiome in corticosteroid response in asthma is unknown. To examine airway microbiome composition in patients with…”
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Molecular networks in atopic mothers impact the risk of infant atopy by Schedel, Michaela, Leach, Sonia M., Strand, Matthew J., Danhorn, Thomas, MacBeth, Morgan, Faino, Anna V., Lynch, Anne M., Winn, Virginia D., Munoz, Lindsay L., Forsberg, Shannon M., Schwartz, David A., Gelfand, Erwin W., Hauk, Pia J.

“…Background The prevalence of atopic diseases has increased with atopic dermatitis (AD) as the earliest manifestation. We assessed if molecular risk factors in…”
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Plasticity of Naturally Occurring Regulatory T Cells in Allergic Airway Disease Is Modulated by the Transcriptional Activity of Il-6 by MacBeth, Morgan, Joetham, Anthony, Gelfand, Erwin W, Schedel, Michaela

“…The impact of naturally occurring regulatory T cells (nTregs) on the suppression or induction of lung allergic responses in mice depends on the nuclear…”
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Mesenchymal Stem Cells Recruit CCR2 + Monocytes To Suppress Allergic Airway Inflammation by Takeda, Katsuyuki, Webb, Tracy L, Ning, Fangkun, Shiraishi, Yoshiki, Regan, Daniel P, Chow, Lyndah, Smith, Mia J, Ashino, Shigeru, Guth, Amanda M, Hopkins, Sophie, Gelfand, Erwin W, Dow, Steven

“…Mesenchymal stem cells (MSC) exert immune modulatory properties and previous studies demonstrated suppressive effects of MSC treatment in animal models of…”
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The other side of asthma: Steroid-refractory disease in the absence of TH2-mediated inflammation by Gelfand, Erwin W., Alam, Rafeul

“…The airway inflammation seen in asthmatic patients can be eosinophilic, neutrophilic, mixed, or paucicellular. Because eosinophils dramatically undergo…”
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CD8 + Tc2 cells: underappreciated contributors to severe asthma by Hinks, Timothy S C, Hoyle, Ryan D, Gelfand, Erwin W

“…The complexity of asthma is underscored by the number of cell types and mediators implicated in the pathogenesis of this heterogeneous syndrome. Type 2 CD4…”
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Therapeutic benefits of recombinant alpha1-antitrypsin IgG1 Fc-fusion protein in experimental emphysema by Takeda, Katsuyuki, Kim, Soo-Hyun, Joetham, Anthony, Petrache, Irina, Gelfand, Erwin W

“…Alpha-1 antitrypsin (AAT) is a major serine protease inhibitor. AAT deficiency (AATD) is a genetic disorder characterized by early-onset severe emphysema. In…”
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Intravenous Immune Globulin in Autoimmune and Inflammatory Diseases by Gelfand, Erwin W

“…Mechanisms of Disease: Intravenous Immune Globulin — How Does It Work? The author reviews the many proposed mechanisms by which intravenous immune globulin may…”
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Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles by Abbott, Jordan K, Chan, Sanny K, MacBeth, Morgan, Crooks, James L, Hancock, Cathy, Knight, Vijaya, Gelfand, Erwin W

“…Despite adequate infection prophylaxis, variation in self-reported quality of life (QOL) throughout the intravenous immunoglobulin (IVIG) infusion cycle is a…”
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1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter by Schedel, Michaela, Jia, Yi, Michel, Sven, Takeda, Katsuyuki, Domenico, Joanne, Joetham, Anthony, Ning, Fangkun, Strand, Matthew, Han, Junyan, Wang, Meiqin, Lucas, Joseph J., Vogelberg, Christian, Kabesch, Michael, O’Connor, Brian P., Gelfand, Erwin W.

“…Effector CD8 + T cells convert from IFN-γ + (Tc1) to IL-13 + (Tc2) cells in the presence of IL-4. Underlying regulatory mechanisms are not fully defined. Here,…”
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Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts by Shearer, William T., MD, PhD, Fleisher, Thomas A., MD, Buckley, Rebecca H., MD, Ballas, Zuhair, MD, Ballow, Mark, MD, Blaese, R. Michael, MD, Bonilla, Francisco A., MD, PhD, Conley, Mary Ellen, MD, Cunningham-Rundles, Charlotte, MD, PhD, Filipovich, Alexandra H., MD, Fuleihan, Ramsay, MD, Gelfand, Erwin W., MD, Hernandez-Trujillo, Vivian, MD, Holland, Steven M., MD, Hong, Richard, MD, Lederman, Howard M., MD, PhD, Malech, Harry L., MD, Miles, Stephen, MD, Notarangelo, Luigi D., MD, Ochs, Hans D., MD, Orange, Jordan S., MD, PhD, Puck, Jennifer M., MD, Routes, John M., MD, Stiehm, E. Richard, MD, Sullivan, Kathleen, MD, PhD, Torgerson, Troy, MD, PhD, Winkelstein, Jerry, MD

“…The present uncertainty of which live viral or bacterial vaccines can be given to immunodeficient patients and the growing neglect of societal adherence to…”
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Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways by Joetham, Anthony, BS, Schedel, Michaela, PhD, O'Connor, Brian P., PhD, Kim, Soohyun, PhD, Takeda, Katsuyuki, MD, PhD, Abbott, Jordan, MD, Gelfand, Erwin W., MD

“…Background Regulatory T cells attenuate development of asthma in wild-type (WT) mice, with both naturally occurring regulatory T (nTreg) cells and inducible…”
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Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype by Jing, Huie, PhD, Zhang, Qian, MD, Zhang, Yu, PhD, Hill, Brenna J., PhD, Dove, Christopher G., BS, Gelfand, Erwin W., MD, Atkinson, T. Prescott, MD, PhD, Uzel, Gulbu, MD, Matthews, Helen F., RN, Mustillo, Peter J., MD, Lewis, David B., MD, Kavadas, Fotini D., MD, Hanson, I. Celine, MD, Kumar, Ashish R., MD, PhD, Geha, Raif S., MD, Douek, Daniel C., MD, PhD, Holland, Steven M., MD, Freeman, Alexandra F., MD, Su, Helen C., MD, PhD

“…Background Autosomal recessive loss-of-function mutations in dedicator of cytokinesis 8 (DOCK8) cause a combined immunodeficiency characterized by atopy,…”
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Is there a link between obesity and asthma? by Kim, Sang-Ha, Sutherland, E Rand, Gelfand, Erwin W

“…Increasing epidemiological data identify a link between obesity and asthma incidence and severity. Based on experimental data, it is possible that shared…”
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Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge by Takeda, Katsuyuki, MD, PhD, Shiraishi, Yoshiki, PhD, Ashino, Shigeru, PhD, Han, Junyan, PhD, Jia, Yi, MD, PhD, Wang, Meiqin, MD, PhD, Lee, Nancy A., PhD, Lee, James J., PhD, Gelfand, Erwin W., MD

“…Background Eosinophils accumulate at the site of allergic inflammation and are critical effector cells in allergic diseases. Recent studies have also suggested…”
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Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses by Ashino, Shigeru, Takeda, Katsuyuki, Li, Hui, Taylor, Vanessa, Joetham, Anthony, Pine, Polly R., Gelfand, Erwin W.

“…Janus kinases (JAKs) are regulators of signaling through cytokine receptors. The importance of JAK1/3 signaling on TH2 differentiation and development of lung…”
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JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders by Ambrus-Aikelin, Geza, Takeda, Katsuyuki, Joetham, Anthony, Lazic, Milos, Povero, Davide, Santini, Angelina M., Pranadinata, Rama, Johnson, Casey D., McGeough, Matthew D., Beasley, Federico C., Stansfield, Ryan, McBride, Christopher, Trzoss, Lynnie, Hoffman, Hal M., Feldstein, Ariel E., Stafford, Jeffrey A., Veal, James M., Bain, Gretchen, Gelfand, Erwin W.

“…The NLRP3 inflammasome is an intracellular, multiprotein complex that promotes the auto-catalytic activation of caspase-1 and the subsequent maturation and…”
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Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies by Maffucci, Patrick, Chavez, Jose, Jurkiw, Thomas J, O'Brien, Patrick J, Abbott, Jordan K, Reynolds, Paul R, Worth, Austen, Notarangelo, Luigi D, Felgentreff, Kerstin, Cortes, Patricia, Boisson, Bertrand, Radigan, Lin, Cobat, Aurélie, Dinakar, Chitra, Ehlayel, Mohammad, Ben-Omran, Tawfeg, Gelfand, Erwin W, Casanova, Jean-Laurent, Cunningham-Rundles, Charlotte

“…We report the molecular, cellular, and clinical features of 5 patients from 3 kindreds with biallelic mutations in the autosomal LIG1 gene encoding DNA ligase…”
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