Search Results - "Gelfand, E. W"

Combined blockade of the histamine H1 and H4 receptor suppresses peanut‐induced intestinal anaphylaxis by regulating dendritic cell function by Wang, M., Han, J., Domenico, J., Shin, Y. S., Jia, Y., Gelfand, E. W.

“…Background Signaling through histamine receptors on dendritic cells (DCs) may be involved in the effector phase of peanut‐induced intestinal anaphylaxis…”
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Role of prostaglandin D2 and CRTH2 blockade in early- and late-phase nasal responses by Shiraishi, Y., Takeda, K., Domenico, J., Gelfand, E. W.

“…Summary Background Prostaglandin D2 (PGD2) plays an important role in allergic inflammation. The PGD2 receptor, CRTH2, is expressed on basophils, eosinophils,…”
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Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography by Hamelmann, E, Schwarze, J, Takeda, K, Oshiba, A, Larsen, G L, Irvin, C G, Gelfand, E W

“…To study the mechanisms and kinetics underlying the development of increased airway responsiveness (AR) after allergic sensitization, animal models have been…”
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IL‐13‐producing BLT1‐positive CD8 cells are increased in asthma and are associated with airway obstruction by Dakhama, A., Collins, M. L., Ohnishi, H., Goleva, E., Leung, D. Y. M., Alam, R., Sutherland, E. R., Martin, R. J., Gelfand, E. W.

“…Background The role of CD8 T lymphocytes in the pathogenesis of asthma is not well understood. We investigated whether a subset of IL‐13‐producing…”
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Mast cell-derived tumour necrosis factor is essential for allergic airway disease by Reuter, S, Heinz, A, Sieren, M, Wiewrodt, R, Gelfand, E. W, Stassen, M, Buhl, R, Taube, C

“…Mast cells are thought to contribute to allergic airway disease. However, the role of mast cell-produced mediators, such as tumour necrosis factor (TNF), for…”
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Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness – a murine model by Hamelmann, E, Tadeda, K, Oshiba, A, Gelfand, EW

“…The importance of IgE in airway inflammation and development of AHR in allergen-sensitized mice has been compared and contrasted in different models of…”
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Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung by Takeda, K, Haczku, A, Lee, J J, Irvin, C G, Gelfand, E W

“…Different strains of mice exhibit different degrees of airway hyperresponsiveness after sensitization to and airway challenge with ovalbumin. Antibody…”
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Effects of combination therapy with montelukast and carbocysteine in allergen‐induced airway hyperresponsiveness and airway inflammation by Takeda, K, Shiraishi, Y, Matsubara, S, Miyahara, N, Matsuda, H, Okamoto, M, Joetham, A, Gelfand, EW

“…Background and purpose:  Montelukast and S‐carbocysteine have been used in asthmatic patients as an anti‐inflammatory or mucolytic agent respectively…”
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A Murine IL-4 Receptor Antagonist That Inhibits IL-4- and IL-13-Induced Responses Prevents Antigen-Induced Airway Eosinophilia and Airway Hyperresponsiveness by Tomkinson, A, Duez, C, Cieslewicz, G, Pratt, J. C, Joetham, A, Shanafelt, M.-C, Gundel, R, Gelfand, E. W

“…The closely related Th2 cytokines, IL-4 and IL-13, share many biological functions that are considered important in the development of allergic airway…”
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Impact of a novel nutritional formula on asthma control and biomarkers of allergic airway inflammation in children by Covar, R., Gleason, M., Macomber, B., Stewart, L., Szefler, P., Engelhardt, K., Murphy, J., Liu, A., Wood, S., DeMichele, S., Gelfand, E. W., Szefler, S. J.

“…Summary Background A novel nutritional formula (NNF) enriched in eicosapentaenoic (EPA) and γ‐linolenic fatty acids and antioxidants reduces airway…”
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Challenges in the use of allogeneic hematopoietic SCT for ectodermal dysplasia with immune deficiency by Fish, J D, Duerst, R E, Gelfand, E W, Orange, J S, Bunin, N

“…Genetic mutations of proteins regulating nuclear factor of κ-light polypeptide gene enhancer in B lymphocyte (NF-κB) activation result in heritable diseases of…”
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IL-10 Is Necessary for the Expression of Airway Hyperresponsiveness but Not Pulmonary Inflammation after Allergic Sensitization by Makela, M. J., Kanehiro, A., Borish, L., Dakhama, A., Loader, J., Joetham, A., Xing, Z., Jordana, M., Larsen, G. L., Gelfand, E. W.

“…Cytokines play an important role in modulating inflammatory responses and, as a result, airway tone. IL-10 is a regulatory cytokine that has been suggested for…”
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Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization by Hamelmann, E, Oshiba, A, Loader, J, Larsen, G L, Gleich, G, Lee, J, Gelfand, E W

“…Eosinophils play a central role in the inflammatory response associated with bronchial asthma. We studied the involvement of eosinophils in the development of…”
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Strain‐specific differences in perivascular inflammation in lungs in two murine models of allergic airway inflammation by Singh, B., Shinagawa, K., Taube, C., Gelfand, E. W., Pabst, R.

“…Summary Histological data show perivascular recruitment of inflammatory cells in lung inflammation. However, the process of perivascular inflammation is…”
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Respiratory viral infections as promoters of allergic sensitization and asthma in animal models by Schwarze, J, Gelfand, E.W

“…Respiratory virus infections can trigger exacerbations of asthma and may also contribute to allergic sensitization to aeroallergens and the development of…”
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A prostacyclin agonist with thromboxane inhibitory activity for airway allergic inflammation in mice by Hayashi, M., Koya, T., Kawakami, H., Sakagami, T., Hasegawa, T., Kagamu, H., Takada, T., Sakai, Y., Suzuki, E., Gelfand, E. W., Gejyo, F.

“…Summary Background ONO‐1301 is a novel drug that acts as a prostacyclin agonist with thromboxane A2 (TxA2) synthase inhibitory activity. We investigated the…”
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Allergic Airway Sensitization Induces T Cell Activation but not Airway Hyperresponsiveness in B Cell-Deficient Mice by Hamelmann, E., Vella, A. T., Oshiba, A., Kappler, J. W., Marrack, P., Gelfand, E. W.

“…B cells play an important role in the allergic response by producing allergen-specific Igs as well as by serving as antigen-presenting cells. We studied the…”
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Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice by Takeda, K, Hamelmann, E, Joetham, A, Shultz, L D, Larsen, G L, Irvin, C G, Gelfand, E W

“…Mast cells are the main effector cells of immediate hypersensitivity and anaphylaxis. Their role in the development of allergen-induced airway…”
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Barometric whole body plethysmography in mice by Schwarze, J, Hamelmann, E, Gelfand, E. W, Adler, Andy, Cieslewicz, Greg, Irvin, Charles G

“…There has been significant utilization of the technique described by Hamelmann et al. ( Am J Respir Crit Care Med 156: 766–775, 1997) in which a parameter,…”
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S-carboxymethylcysteine normalises airway responsiveness in sensitised and challenged mice by Takeda, K, Miyahara, N, Kodama, T, Taube, C, Balhorn, A, Dakhama, A, Kitamura, K, Hirano, A, Tanimoto, M, Gelfand, E. W

“…S-carboxymethylcysteine (S-CMC) has been used as a mucoregulator in respiratory diseases. However, the mechanism of action of S-CMC on allergic airway…”
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