Search Results - "Gelfand, Bradley D"

A Revised Hemodynamic Theory of Age-Related Macular Degeneration by Gelfand, Bradley D, Ambati, Jayakrishna

“…Age-related macular degeneration (AMD) afflicts one out of every 40 individuals worldwide, causing irreversible central blindness in millions. The…”
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DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 by Tarallo, Valeria, Hirano, Yoshio, Gelfand, Bradley D., Dridi, Sami, Kerur, Nagaraj, Kim, Younghee, Cho, Won Gil, Kaneko, Hiroki, Fowler, Benjamin J., Bogdanovich, Sasha, Albuquerque, Romulo J.C., Hauswirth, William W., Chiodo, Vince A., Kugel, Jennifer F., Goodrich, James A., Ponicsan, Steven L., Chaudhuri, Gautam, Murphy, Michael P., Dunaief, Joshua L., Ambati, Balamurali K., Ogura, Yuichiro, Yoo, Jae Wook, Lee, Dong-ki, Provost, Patrick, Hinton, David R., Núñez, Gabriel, Baffi, Judit Z., Kleinman, Mark E., Ambati, Jayakrishna

“…Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form…”
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Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration by Ambati, Meenakshi, Apicella, Ivana, Wang, Shao-bin, Narendran, Siddharth, Leung, Hannah, Pereira, Felipe, Nagasaka, Yosuke, Huang, Peirong, Varshney, Akhil, Baker, Kirstie L., Marion, Kenneth M., Shadmehr, Mehrdad, Stains, Cliff I., Werner, Brian C., Sadda, Srinivas R., Taylor, Ethan W., Sutton, S. Scott, Magagnoli, Joseph, Gelfand, Bradley D.

“…The atrophic form of age-related macular degeneration (dry AMD) affects nearly 200 million people worldwide. There is no Food and Drug Administration…”
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A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling by Banerjee, Daipayan, Langberg, Kurt, Abbas, Salar, Odermatt, Eric, Yerramothu, Praveen, Volaric, Martin, Reidenbach, Matthew A., Krentz, Kathy J., Rubinstein, C. Dustin, Brautigan, David L., Abbas, Tarek, Gelfand, Bradley D., Ambati, Jayakrishna, Kerur, Nagaraj

“…Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), produced by cyclic GMP-AMP synthase (cGAS), stimulates the production of type I interferons…”
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Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity by Fowler, Benjamin J., Gelfand, Bradley D., Kim, Younghee, Kerur, Nagaraj, Tarallo, Valeria, Hirano, Yoshio, Amarnath, Shoba, Fowler, Daniel H., Radwan, Marta, Young, Mark T., Pittman, Keir, Kubes, Paul, Agarwal, Hitesh K., Parang, Keykavous, Hinton, David R., Bastos-Carvalho, Ana, Li, Shengjian, Yasuma, Tetsuhiro, Mizutani, Takeshi, Yasuma, Reo, Wright, Charles, Ambati, Jayakrishna

“…Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that block retrovirus replication. Alu (an endogenous retroelement that…”
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Compartmentalized citrullination in Muller glial endfeet during retinal degeneration by Palko, Sarah I, Saba, Nicholas J, Mullane, Elias, Nicholas, Benjamin D, Nagasaka, Yosuke, Ambati, Jayakrishna, Gelfand, Bradley D, Ishigami, Akihito, Bargagna-Mohan, Paola, Mohan, Royce

“…Muller glia (MG) play a central role in reactive gliosis, a stress response associated with rare and common retinal degenerative diseases, including…”
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Effects of donor-specific microvascular anatomy on hemodynamic perfusion in human choriocapillaris by An, Senyou, Yu, Huidan, Islam, MD Mahfuzul, Zhang, Xiaoyu, Zhan, Yuting, Olivieri, Joseph J., Ambati, Jayakrishna, Yao, Jun, Gelfand, Bradley D.

“…Evidence from histopathology and clinical imaging suggest that choroidal anatomy and hemodynamic perfusion are among the earliest changes in retinal diseases…”
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Subretinal injection in mice to study retinal physiology and disease by Huang, Peirong, Narendran, Siddharth, Pereira, Felipe, Fukuda, Shinichi, Nagasaka, Yosuke, Apicella, Ivana, Yerramothu, Praveen, Marion, Kenneth M., Cai, Xiaoyu, Sadda, Srinivas R., Gelfand, Bradley D., Ambati, Jayakrishna

“…Subretinal injection (SRI) is a widely used technique in retinal research and can be used to deliver nucleic acids, small molecules, macromolecules, viruses,…”
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Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice by Wright, Charles B., Uehara, Hironori, Kim, Younghee, Yasuma, Tetsuhiro, Yasuma, Reo, Hirahara, Shuichiro, Makin, Ryan D., Apicella, Ivana, Pereira, Felipe, Nagasaka, Yosuke, Narendran, Siddharth, Fukuda, Shinichi, Albuquerque, Romulo, Fowler, Benjamin J., Bastos-Carvalho, Ana, Georgel, Philippe, Hatada, Izuho, Chang, Bo, Kerur, Nagaraj, Ambati, Balamurali K., Ambati, Jayakrishna, Gelfand, Bradley D.

“…Degeneration of the retinal pigmented epithelium (RPE) and aberrant blood vessel growth in the eye are advanced-stage processes in blinding diseases such as…”
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Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome by Gelfand, Bradley D., Wright, Charles B., Kim, Younghee, Yasuma, Tetsuhiro, Yasuma, Reo, Li, Shengjian, Fowler, Benjamin J., Bastos-Carvalho, Ana, Kerur, Nagaraj, Uittenbogaard, Annette, Han, Youn Seon, Lou, Dingyuan, Kleinman, Mark E., McDonald, W. Hayes, Núñez, Gabriel, Georgel, Philippe, Dunaief, Joshua L., Ambati, Jayakrishna

“…Excess iron induces tissue damage and is implicated in age-related macular degeneration (AMD). Iron toxicity is widely attributed to hydroxyl radical formation…”
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DICER1/Alu RNA dysmetabolism induces Caspase-8–mediated cell death in age-related macular degeneration by Kim, Younghee, Tarallo, Valeria, Kerur, Nagaraj, Yasuma, Tetsuhiro, Gelfand, Bradley D., Bastos-Carvalho, Ana, Hirano, Yoshio, Yasuma, Reo, Mizutani, Takeshi, Fowler, Benjamin J., Li, Shengjian, Kaneko, Hiroki, Bogdanovich, Sasha, Ambati, Balamurali K., Hinton, David R., Hauswirth, William W., Hakem, Razqallah, Wright, Charles, Ambati, Jayakrishna

“…Significance Geographic atrophy is a late stage of age-related macular degeneration (AMD) that causes blindness in millions worldwide characterized by death of…”
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Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice by Mizutani, Takeshi, Fowler, Benjamin J, Kim, Younghee, Yasuma, Reo, Krueger, Laura A, Gelfand, Bradley D, Ambati, Jayakrishna

“…To evaluate the efficacy of nucleoside reverse transcriptase inhibitors (NRTIs) in the laser-induced mouse model of choroidal neovascularization (CNV). We…”
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A Clinical Metabolite of Azidothymidine Inhibits Experimental Choroidal Neovascularization and Retinal Pigmented Epithelium Degeneration by Narendran, Siddharth, Pereira, Felipe, Yerramothu, Praveen, Apicella, Ivana, Wang, Shao-Bin, Varshney, Akhil, Baker, Kirstie L, Marion, Kenneth M, Ambati, Meenakshi, Ambati, Vidya L, Ambati, Kameshwari, Sadda, Srinivas R, Gelfand, Bradley D, Ambati, Jayakrishna

“…Azidothymidine (AZT), a nucleoside reverse transcriptase inhibitor, possesses anti-inflammatory and anti-angiogenic activity independent of its ability to…”
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ERK1/2 activation is a therapeutic target in age-related macular degeneration by Dridi, Sami, Hirano, Yoshio, Tarallo, Valeria, Kim, Younghee, Fowler, Benjamin J, Ambati, Balamurali K, Bogdanovich, Sasha, Chiodo, Vince A, Hauswirth, William W, Kugel, Jennifer F, Goodrich, James A, Ponicsan, Steven L, Hinton, David R, Kleinman, Mark E, Baffi, Judit Z, Gelfand, Bradley D, Ambati, Jayakrishna

“…Deficient expression of the RNase III DICER1, which leads to the accumulation of cytotoxic Alu RNA, has been implicated in degeneration of the retinal…”
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Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization by Wang, Shao-bin, Nagasaka, Yosuke, Argyle, Dionne, Nagasaka, Ayami, Yerramothu, Praveen, Gelfand, Bradley D., Ambati, Jayakrishna

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Short-interfering RNAs Induce Retinal Degeneration via TLR3 and IRF3 by Kleinman, Mark E, Kaneko, Hiroki, Cho, Won Gil, Dridi, Sami, Fowler, Benjamin J, Blandford, Alexander D, Albuquerque, Romulo JC, Hirano, Yoshio, Terasaki, Hiroko, Kondo, Mineo, Fujita, Takashi, Ambati, Balamurali K, Tarallo, Valeria, Gelfand, Bradley D, Bogdanovich, Sasha, Baffi, Judit Z, Ambati, Jayakrishna

“…The discovery of sequence-specific gene silencing by endogenous double-stranded RNAs (dsRNA) has propelled synthetic short-interfering RNAs (siRNAs) to the…”
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Survey of commercial antibodies targeting Y chromosome‐encoded genes by Gelfand, Bradley D., Argyle, Dionne A., Olivieri, Joseph J., Ambati, Jayakrishna

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Endothelial Cell PECAM-1 Promotes Atherosclerotic Lesions in Areas of Disturbed Flow in ApoE-Deficient Mice by Harry, Brian L, Sanders, John M, Feaver, Ryan E, Lansey, Melissa, Deem, Tracy L, Zarbock, Alexander, Bruce, Anthony C, Pryor, Andrew W, Gelfand, Bradley D, Blackman, Brett R, Schwartz, Martin A, Ley, Klaus

“…OBJECTIVE—Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) has recently been shown to form an essential element of a mechanosensory complex that…”
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Y chromosome proteins in female tissues by Gelfand, Bradley D, Ambati, Jayakrishna

“…Unreliable protein-based tools are impeding sex-based research…”
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The Learning Curve of Murine Subretinal Injection Among Clinically Trained Ophthalmic Surgeons by Huang, Peirong, Narendran, Siddharth, Pereira, Felipe, Fukuda, Shinichi, Nagasaka, Yosuke, Apicella, Ivana, Yerramothu, Praveen, Marion, Kenneth M, Cai, Xiaoyu, Sadda, Srinivas R, Gelfand, Bradley D, Ambati, Jayakrishna

“…Subretinal injection (SRI) in mice is widely used in retinal research, yet the learning curve (LC) of this surgically challenging technique is unknown. To…”
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