Search Results - "Geles, Kenneth G."

Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture by Chen, Shuang, Giannakou, Andreas, Wyman, Sarah, Gruzas, Janet, Golas, Jonathon, Zhong, Wenyan, Loreth, Christine, Sridharan, Latha, Yamin, Ting-Ting, Damelin, Marc, Geles, Kenneth G.

“…Tumorigenesis depends on intricate interactions between genetically altered tumor cells and their surrounding microenvironment. While oncogenic drivers in lung…”
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Intra-Tumoral Activation of Endosomal TLR Pathways Reveals a Distinct Role for TLR3 Agonist Dependent Type-1 Interferons in Shaping the Tumor Immune Microenvironment by Thomas, Graham, Micci, Luca, Yang, Wenjing, Katakowski, Joseph, Oderup, Cecilia, Sundar, Purnima, Wang, Xiao, Geles, Kenneth G., Potluri, Shobha, Salek-Ardakani, Shahram

“…Toll-like receptor (TLR) agonists have received considerable attention as therapeutic targets for cancer immunotherapy owing to their ability to convert…”
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Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID by Falender, Allison E, Freiman, Richard N, Geles, Kenneth G, Lo, Kirk C, Hwang, KeumSil, Lamb, Dolores J, Morris, Patricia L, Tjian, Robert, Richards, JoAnne S

“…The establishment and maintenance of spermatogenesis in mammals requires specialized networks of gene expression programs in the testis. The gonad-specific…”
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NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells by Geles, Kenneth G., Gao, Yijie, Giannakou, Andreas, Sridharan, Latha, Yamin, Ting-Ting, Zhang, Jing, Karim, Riyez, Bard, Joel, Piche-Nicholas, Nicole, Charati, Manoj, Maderna, Andreas, Lucas, Judy, Golas, Jonathon, Guffroy, Magali, Pirie-Shepherd, Steven, Roy, Marc, Qian, Jessie, Franks, Tania, Zhong, Wenyan, O’Donnell, Christopher J., Tchistiakova, Lioudmila, Gerber, Hans-Peter, Sapra, Puja

“…Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive…”
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Upregulation of RNA Processing Factors in Poorly Differentiated Lung Cancer Cells by Geles, Kenneth G, Zhong, Wenyan, O’Brien, Siobhan K, Baxter, Michelle, Loreth, Christine, Pallares, Diego, Damelin, Marc

“…Abstract Intratumoral heterogeneity in non–small cell lung cancer (NSCLC) has been appreciated at the histological and cellular levels, but the association of…”
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Tumour-initiating cells: challenges and opportunities for anticancer drug discovery by Zhou, Bin-Bing S, Grindley, Justin C, Zhang, Haiying, Damelin, Marc, Geles, Kenneth G, Dirks, Peter B

“…Key Points The experimental demonstration of tumour-initiating cells (popularly known as cancer stem cells) in several human tumours in recent years supports…”
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Cell-Type-Selective Induction of C-Jun by TAF4b Directs Ovarian-Specific Transcription Networks by Geles, Kenneth G., Freiman, Richard N., Liu, Wei-Li, Zheng, Shuang, Voronina, Ekaterina, Tjian, Robert

“…Cell-type-selective expression of the TFIID subunit $TAF_{II}105$ (renamed TAF4b) in the ovary is essential for proper follicle development. Although a…”
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Codependent Activators Direct Myoblast-Specific MyoD Transcription by Hu, Ping, Geles, Kenneth G., Paik, Ji-Hye, DePinho, Ronald A., Tjian, Robert

“…Although FoxO and Pax proteins represent two important families of transcription factors in determining cell fate, they had not been functionally or physically…”
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Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2 by Dann, Stephen G, Ryskin, Michael, Barsotti, Anthony M, Golas, Jonathon, Shi, Celine, Miranda, Miriam, Hosselet, Christine, Lemon, Luanna, Lucas, Judy, Karnoub, Maha, Wang, Fang, Myers, Jeremy S, Garza, Scott J, Follettie, Maximillian T, Geles, Kenneth G, Klippel, Anke, Rollins, Robert A, Fantin, Valeria R

“…Lat1 (SLC7A5) is an amino acid transporter often required for tumor cell import of essential amino acids (AA) including Methionine ( Met ). Met is the obligate…”
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Long-term tumor regression induced by an antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells by Sapra, Puja, Damelin, Marc, Dijoseph, John, Marquette, Kimberly, Geles, Kenneth G, Golas, Jonathon, Dougher, Maureen, Narayanan, Bitha, Giannakou, Andreas, Khandke, Kiran, Dushin, Russell, Ernstoff, Elana, Lucas, Judy, Leal, Mauricio, Hu, George, O'Donnell, Christopher J, Tchistiakova, Lioudmila, Abraham, Robert T, Gerber, Hans-Peter

“…Antibody-drug conjugates (ADC) represent a promising therapeutic modality for the clinical management of cancer. We sought to develop a novel ADC that targets…”
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Delineation of a Cellular Hierarchy in Lung Cancer Reveals an Oncofetal Antigen Expressed on Tumor-Initiating Cells by DAMELIN, Marc, GELES, Kenneth G, BEHRENS, Carmen, CHOE, Sung E, RIOS, Carol, GRUZAS, Janet, SRIDHARAN, Latha, DOUGHER, Maureen, KUNZ, Arthur, HAMANN, Philip R, EVANS, Deborah, ARMELLINO, Douglas, FOLLETTIE, Maximillian T, KHANDKE, Kiran, MARQUETTE, Kimberly, TCHISTIAKOVA, Lioudmila, BOGHAERT, Erwin R, ABRAHAM, Robert T, WISTUBA, Ignacio I, ZHOU, Bin-Bing S, PING YUAN, BAXTER, Michelle, GOLAS, Jonathon, DIJOSEPH, John F, KARNOUB, Maha, SHUGUANG HUANG, DIESL, Veronica

“…Poorly differentiated tumors in non-small cell lung cancer (NSCLC) have been associated with shorter patient survival and shorter time to recurrence following…”
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Structural Changes in TAF4b-TFIID Correlate with Promoter Selectivity by Liu, Wei-Li, Coleman, Robert A., Grob, Patricia, King, David S., Florens, Laurence, Washburn, Michael P., Geles, Kenneth G., Yang, Joyce L., Ramey, Vincent, Nogales, Eva, Tjian, Robert

“…Proper ovarian development requires the cell type-specific transcription factor TAF4b, a subunit of the core promoter recognition complex TFIID. We present the…”
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Germline and developmental roles of the nuclear transport factor importin α3 in C. elegans by Geles, Kenneth G., Adam, Stephen A.

“…ABSTRACT The importin α family of transport factors mediates the nuclear import of classical nuclear localization signal- containing proteins. In order to…”
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A role for Caenorhabditis elegans importin IMA-2 in germ line and embryonic mitosis by Geles, Kenneth G, Johnson, Jeffrey J, Jong, Sena, Adam, Stephen A

“…The importin alpha family of nuclear-cytoplasmic transport factors mediates the nuclear localization of proteins containing classical nuclear localization…”
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Abstract 4905: Novel gene expression profiles of poorly differentiated lung cancer are enriched in stem cell factors and predictive of worse clinical outcome by Damelin, Marc Isaac, Zhong, Wenyan, Diesl, Veronica K., Follettie, Maximillian T., Geles, Kenneth G.

“…Abstract Poorly differentiated non-small cell lung cancer (NSCLC) at the histopathological level has been associated with shorter patient survival…”
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Abstract 1697: Therapeutic targeting the NOTCH3 receptor with antibody drug conjugates by Geles, Kenneth G., Gao, Yijie, Sridharan, Latha, Giannakou, Andreas, Yamin, Ting-Ting, Golas, Jonathan, Lucas, Judy, Charati, Manoj, Li, Xiantang, Guffroy, Magali, Nichols, Tim, Wang, Kai, Follettie, Max, Maderna, Andreas, Tchistiakova, Lioudmila, Gerber, Hans-Peter, Sapra, Puja

“…Abstract Activation and mutation of the NOTCH signaling pathway is oncogenic in many tissue types and the target of multiple anti-cancer therapies currently in…”
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Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH 2 by Dann, Stephen G, Ryskin, Michael, Barsotti, Anthony M, Golas, Jonathon, Shi, Celine, Miranda, Miriam, Hosselet, Christine, Lemon, Luanna, Lucas, Judy, Karnoub, Maha, Wang, Fang, Myers, Jeremy S, Garza, Scott J, Follettie, Maximillian T, Geles, Kenneth G, Klippel, Anke, Rollins, Robert A, Fantin, Valeria R

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Abstract 5471: Notch-antibody drug conjugates have a different mechanism of action than Notch signaling inhibitors and induce tumor regression by Geles, Kenneth G., Gao, Yijie, Sridharan, Latha, Giannakou, Andreas, Yamin, Ting-Ting, Golas, Jonathan, Charati, Manoj, Khandke, Kiran, Lucas, Judy, Maderna, Andreas, O'Donnell, Christopher J., Tchistiakova, Lioudmila, Gerber, Hans-Peter, Sapra, Puja

“…Abstract There are four different Notch receptors in mammalian cells that have overlapping patterns of expression in embryonic and adult tissues, but fulfill…”
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Abstract 4752: Preclinical development and translational research on a novel antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells by Sapra, Puja, Damelin, Marc, Marquette, Kimberly, Geles, Kenneth G., Golas, Jonathon, Dougher, Maureen, Narayanan, Bitha, Giannakou, Andreas, Khandke, Kiran, Dushin, Russell, Ernstoff, Elana, Lucas, Judy, Leal, Mauricio, Hu, George, Betts, Alison, Haddish-Berhane, Nahor, Powell, Eric, Pirie-Shepherd, Steven, O'Donnell, Christopher, Tchistiakova, Lioudmila, Gerber, Hans-Peter, Marrinucci, Dena, Tucker, Eric

“…Abstract Antibody-drug conjugates (ADCs) represent a promising therapeutic modality for the clinical management of cancer. We sought to develop a novel ADC…”
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Codependent Activators Direct Myoblast-Specific MyoD Transcription by Hu, Ping, Geles, Kenneth G, Paik, Ji-Hye, DePinho, Ronald A, Tjian, Robert

“…Although FoxO and Pax proteins represent two important families of transcription factors in determining cell fate, they had not been functionally or physically…”
Get full text