Effect of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity

This study aimed to contribute to the literature on the prevention and treatment of ototoxicity due to various drugs and chemicals. This study compared the histological effects of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity, in 36 rats. Dex...

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Bibliographic Details
Published in:	Journal of laryngology and otology Vol. 126; no. 11; p. 1091
Main Authors:	Topdag, M, Iseri, M, Gelenli, E, Yardimoglu, M, Yazir, Y, Ulubil, S A, Topdag, D O, Ustundag, E
Format:	Journal Article
Language:	English
Published:	England 01-11-2012
Subjects:	Animals Antineoplastic Agents - adverse effects Apoptosis - drug effects Cisplatin - adverse effects Dexamethasone - administration & dosage Female Labyrinth Diseases - chemically induced Labyrinth Diseases - drug therapy Memantine - administration & dosage Piracetam - administration & dosage Rats Rats, Wistar Tympanic Membrane - drug effects
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Summary:	This study aimed to contribute to the literature on the prevention and treatment of ototoxicity due to various drugs and chemicals. This study compared the histological effects of intratympanic dexamethasone, memantine and piracetam on cellular apoptosis due to cisplatin ototoxicity, in 36 rats. Dexamethasone and memantine had significant effects on the stria vascularis, organ of Corti and spiral ganglion (p < 0.05). Although piracetam decreased the apoptosis rate, this effect was not statistically significant (p > 0.05). Dexamethasone and memantine were found superior to piracetam in reducing apoptosis due to cisplatin ototoxicity. Further studies of this subject are needed, incorporating electron microscopy and auditory brainstem response testing.
ISSN:	1748-5460
DOI:	10.1017/S0022215112001855