Search Results - "Gelebart, Pascal"

Stabilization of β-catenin upon B-cell receptor signaling promotes NF-kB target genes transcription in mantle cell lymphoma by Lazarian, Gregory, Friedrich, Chloe, Quinquenel, Anne, Tran, Julie, Ouriemmi, Souhail, Dondi, Elisabetta, Martin, Antoine, Mihoub, Imane, Chiron, David, Bellanger, Céline, Fleury, Carole, Gélébart, Pascal, McCormack, Emmet, Ledoux, Dominique, Thieblemont, Catherine, Marzec, Jacek, Gribben, John G., Cymbalista, Florence, Varin-Blank, Nadine, Gardano, Laura, Baran-Marszak, Fanny

“…B-cell receptor (BCR) signaling pathways and interactions with the tumor microenvironment account for mantle cell lymphoma (MCL) cells survival in lymphoid…”
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Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma by Gelebart, Pascal, Zak, Zoulika, Anand, Mona, Belch, Andrew, Lai, Raymond

“…Fatty acid synthase (FASN), a key player in the de novo synthetic pathway of long-chain fatty acids, has been shown to contribute to the tumorigenesis in…”
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Calreticulin, a Ca2+-binding chaperone of the endoplasmic reticulum by Gelebart, Pascal, Opas, Michal, Michalak, Marek

“…Calreticulin is a 46-kDa Ca2+-binding chaperone found across a diverse range of species. The protein is involved in the regulation of intracellular Ca2+…”
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β-catenin is constitutively active and increases STAT3 expression/activation in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma by ANAND, Mona, LAI, Raymond, GELEBART, Pascal

“…The role of β-catenin in cancer has been most studied in tumors of epithelial cell origin. The functional status and biological significance of this protein in…”
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Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16 by Casey, Nicholas P, Kleinmanns, Katrin, Forcados, Christopher, Gelebart, Pascal F, Joaquina, Sandy, Lode, Martine, Benard, Emmanuelle, Kaveh, Fatemeh, Caulier, Benjamin, Helgestad Gjerde, Christiane, García de Jalón, Elvira, Warren, David J, Lindemann, Kristina, Rokkones, Erik, Davidson, Ben, Myhre, Marit Renee, Kvalheim, Gunnar, Bjørge, Line, McCormack, Emmet, Inderberg, Else Marit, Wälchli, Sébastien

“…BackgroundOvarian cancer (OC) is the leading cause of death from gynecologic malignancies in the Western world. Contributing factors include a high frequency…”
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Xenograft Models of Primary Acute Myeloid Leukemia for the Development of Imaging Strategies and Evaluation of Novel Targeted Therapies by Gelebart, Pascal, Popa, Mihaela, McCormack, Emmet

“…Despite the tremendous progress made in the comprehension of acute myeloid leukemia (AML) over the last 30 years most patients die from their disease. Our…”
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Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma by Gelebart, Pascal, Anand, Mona, Armanious, Hanan, Peters, Anthea C., Dien Bard, Jennifer, Amin, Hesham M., Lai, Raymond

“…Aberrations of the Wnt canonical pathway (WCP) are known to contribute to the pathogenesis of various types of cancer. We hypothesize that these defects may…”
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Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells by Eriksen‐Gjerstad, May, Tveit Karlsen, Ida, Fandalyuk, Zinayida, Benjaminsen, Susanne, Baran‐Marszak, Fanny, Papp, Bela, Locke, Frederick, Ladds, Marcus, Pastor‐Fernández, Andrés, Gelebart, Pascal, Mc Cormack, Emmet

“…Mantle cell lymphoma (MCL) is a non‐Hodgkin lymphoma that remains incurable with the treatment options available today. In the present study, we have…”
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Endoplasmic reticulum calcium pumps and cancer cell differentiation by Papp, Béla, Brouland, Jean-Philippe, Arbabian, Atousa, Gélébart, Pascal, Kovács, Tünde, Bobe, Régis, Enouf, Jocelyne, Varin-Blank, Nadine, Apáti, Agota

“…The endoplasmic reticulum (ER) is a major intracellular calcium storage pool and a multifunctional organelle that accomplishes several calcium-dependent…”
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Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca²⁺-dependent signaling cascade by Lynch, Jeffrey, Guo, Lei, Gelebart, Pascal, Chilibeck, Kaari, Xu, Jian, Molkentin, Jeffery D, Agellon, Luis B, Michalak, Marek

“…We uncovered a new pathway of interplay between calreticulin and myocyte-enhancer factor (MEF) 2C, a cardiac-specific transcription factor. We establish that…”
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Clinical and biological significance of GSK-3 β inactivation in breast cancer—an immunohistochemical study by Armanious, Hanan, MD, PhD, Deschenes, Jean, MD, FRCP, Gelebart, Pascal, PhD, Ghosh, Sunita, PhD, Mackey, John, MD, FRCP, Lai, Raymond, MD, PhD, FRCP

“…Summary Glycogen synthase kinase 3 β , recently found to be functionally abnormal in various types of human disease, is negatively regulated by the PI3K/Akt…”
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Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c) by Dally, Saoussen, Bredoux, Raymonde, Corvazier, Elisabeth, Andersen, Jens P, Clausen, Johannes D, Dode, Leonard, Fanchaouy, Mohammed, Gelebart, Pascal, Monceau, Virginie, Del Monte, Frederica, Gwathmey, Judith K, Hajjar, Roger, Chaabane, Chiraz, Bobe, Régis, Raies, Aly, Enouf, Jocelyne

“…We recently documented the expression of a novel human mRNA variant encoding a yet uncharacterized SERCA [SR (sarcoplasmic reticulum)/ER (endoplasmic…”
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Gene Methylation and Silencing of WIF1 Is a Frequent Genetic Abnormality in Mantle Cell Lymphoma by Alshareef, Abdulraheem, Peters, Anthea C, Gélébart, Pascal, Chen, Will, Lai, Raymond

“…We have previously shown that the Wnt canonical pathway (WCP) is constitutively active in most cases of mantle cell lymphoma (MCL). Here, we aimed to elucidate…”
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Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation by Papp, Bela, Launay, Sophie, Gélébart, Pascal, Arbabian, Atousa, Enyedi, Agnes, Brouland, Jean-Philippe, Carosella, Edgardo D, Adle-Biassette, Homa

“…Endoplasmic reticulum (ER) calcium homeostasis plays an essential role in cellular calcium signaling, intra-ER protein chaperoning and maturation, as well as…”
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Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours by Adle-Biassette, Homa, Ricci, Riccardo, Martin, Antoine, Martini, Maurizio, Ravegnini, Gloria, Kaci, Rachid, Gélébart, Pascal, Poirot, Brigitte, Sándor, Zsuzsanna, Lehman-Che, Jacqueline, Tóth, Erika, Papp, Bela

“…Accurate characterisation of gastrointestinal stromal tumours (GIST) is important for prognosis and the choice of targeted therapies. Histologically the…”
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Endoplasmic reticulum calcium pumps and cancer by Arbabian, Atousa, Brouland, Jean-Philippe, Gélébart, Pascal, Kovàcs, Tünde, Bobe, Régis, Enouf, Jocelyne, Papp, Béla

“…Endoplasmic reticulum calcium homeostasis is involved in a multitude of signaling, as well as “house‐keeping” functions that control cell growth,…”
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Inhibition of a new AXL isoform, AXL3, induces apoptosis of mantle cell lymphoma cells by Gelebart, Pascal, Eriksen Gjerstad, May, Benjaminsen, Susanne, Han, Jianhua, Karlsen, Ida, Safont, Mireia Mayoral, Leitch, Calum, Fandalyuk, Zinayida, Popa, Mihaela, Helgeland, Lars, Papp, Bela, Baran-Marszak, Fanny, McCormack, Emmet

“…•The newly identified AXL3 isoform is aberrantly expressed and represents a new biomarker and therapeutic target for MCL.•In a preclinical model of MCL,…”
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The Loss of Sarco/Endoplasmic Reticulum Calcium Transport ATPase 3 Expression Is an Early Event during the Multistep Process of Colon Carcinogenesis by Brouland, Jean-Philippe, Gélébart, Pascal, Kovàcs, Tünde, Enouf, Jocelyne, Grossmann, Johannes, Papp, Béla

“…Calcium accumulation in the endoplasmic reticulum is accomplished by sarco/endoplasmic reticulum calcium transport ATPases (SERCA enzymes). To better…”
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Inhibition of a new AXL isoform (AXL3) induces apoptosis of mantle cell lymphoma cells by Gelebart, Pascal Francois, Gjerstad, May Eriksen, Benjaminsen, Susanne, Han, Jianhua, Karlsen, Ida, Mayoral Safont, Mireia, Leitch, Calum, Fandalyuk, Zinayida, Popa, Mihaela-Lucia, Helgeland, Lars, Papp, Bela, Baran-Marszak, Fanny, Mc Cormack, Emmet

“…Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma having a poor overall survival that is in need for the development of new therapeutics…”
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Constitutive activation of metalloproteinase ADAM10 in mantle cell lymphoma promotes cell growth and activates the TNFα/NFκB pathway by Armanious, Hanan, Gelebart, Pascal, Anand, Mona, Belch, Andrew, Lai, Raymond

“…One of the main functions of A Disintegrin and Metalloproteinase 10 (ADAM10) is to regulate the bioavailability of adhesion molecules and ligands to various…”
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