Search Results - "Gelb, MH"

Blocking Protein Farnesyltransferase Improves Nuclear Blebbing in Mouse Fibroblasts with a Targeted Hutchinson-Gilford Progeria Syndrome Mutation by Yang, Shao H., Bergo, Martin O., Toth, Julia I., Qiao, Xin, Hu, Yan, Sandoval, Salemiz, Meta, Margarita, Bendale, Pravin, Gelb, Michael H., Young, Stephen G., Fong, Loren G., Steinberg, Daniel

“…Hutchinson-Gilford progeria syndrome (HGPS), a progeroid syndrome in children, is caused by mutations in LMNA (the gene for prelamin A and lamin C) that result…”
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Blocking Protein Farnesyltransferase Improves Nuclear Shape in Fibroblasts from Humans with Progeroid Syndromes by Toth, Julia I., Yang, Shao H., Qiao, Xin, Beigneux, Anne P., Gelb, Michael H., Moulson, Casey L., Miner, Jeffrey H., Young, Stephen G., Fong, Loren G., Havel, Richard J.

“…Defects in the biogenesis of lamin A from its farnesylated precursor, prelamin A, lead to the accumulation of prelamin A at the nuclear envelope, cause…”
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Computational protein design enables a novel one-carbon assimilation pathway by Siegel, Justin B., Lee Smith, Amanda, Poust, Sean, Wargacki, Adam J., Bar-Even, Arren, Louw, Catherine, Shen, Betty W., Eiben, Christopher B., Tran, Huu M., Noor, Elad, Gallaher, Jasmine L., Bale, Jacob, Yoshikuni, Yasuo, Gelb, Michael H., Keasling, Jay D., Stoddard, Barry L., Lidstrom, Mary E., Baker, David

“…We describe a computationally designed enzyme, formolase (FLS), which catalyzes the carboligation of three one-carbon formaldehyde molecules into one…”
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Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples by O’Donnell, Valerie B., Schebb, Nils H., Milne, Ginger L., Murphy, Michael P., Thomas, Christopher P., Steinhilber, Dieter, Gelhaus, Stacy L., Kühn, Hartmut, Gelb, Michael H., Jakobsson, Per-Johan, Blair, Ian A., Murphy, Robert C., Freeman, Bruce A., Brash, Alan R., FitzGerald, Garret A.

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Psychosine, a marker of Krabbe phenotype and treatment effect by Escolar, M.L., Kiely, B.T., Shawgo, E., Hong, X., Gelb, M.H., Orsini, J.J., Matern, D., Poe, M.D.

“…Newborn screening (NBS) for Krabbe disease, a rare neurodegenerative disorder caused by deficient galactocerebrosidase (GALC) enzyme activity, has recently…”
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Interfacial enzymology: the secreted phospholipase A(2)-paradigm by Berg, O G, Gelb, M H, Tsai, M D, Jain, M K

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Direct Multiplex Assay of Lysosomal Enzymes in Dried Blood Spots for Newborn Screening by Li, Yijun, Scott, C. Ronald, Chamoles, Nestor A, Ghavami, Ahmad, Pinto, B. Mario, Turecek, Frantisek, Gelb, Michael H

“…Newborn screening for deficiency in the lysosomal enzymes that cause Fabry, Gaucher, Krabbe, Niemann-Pick A/B, and Pompe diseases is warranted because…”
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Quantitative analysis of complex protein mixtures using isotope-coded affinity tags by Aebersold, Ruedi, Gygi, Steven P, Rist, Beate, Gerber, Scott A, Turecek, Frantisek, Gelb, Michael H

“…We describe an approach for the accurate quantification and concurrent sequence identification of the individual proteins within complex mixtures. The method…”
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Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome by Mallampalli, Monica P, Huyer, Gregory, Bendale, Pravin, Gelb, Michael H, Michaelis, Susan

“…Hutchinson-Gilford progeria syndrome (HGPS) is a devastating premature aging disease resulting from a mutation in the LMNA gene, which encodes nuclear lamins A…”
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Novel human secreted phospholipase A(2) with homology to the group III bee venom enzyme by Valentin, E, Ghomashchi, F, Gelb, M H, Lazdunski, M, Lambeau, G

“…Venom and mammalian secreted phospholipases A(2) (sPLA(2)s) have been associated with numerous physiological, pathological, and toxic processes. So far,…”
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On the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes by Valentin, E, Ghomashchi, F, Gelb, M H, Lazdunski, M, Lambeau, G

“…Over the last decade, an expanding diversity of secreted phospholipases A(2) (sPLA(2)s) has been identified in mammals. Here, we report the cloning in mice of…”
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Protein Farnesyltransferase Inhibitors Exhibit Potent Antimalarial Activity by Nallan, Laxman, Bauer, Kevin D, Bendale, Pravin, Rivas, Kasey, Yokoyama, Kohei, Hornéy, Carolyn P, Pendyala, Prakash Rao, Floyd, David, Lombardo, Louis J, Williams, David K, Hamilton, Andrew, Sebti, Said, Windsor, William T, Weber, Patricia C, Buckner, Frederick S, Chakrabarti, Debopam, Gelb, Michael H, Van Voorhis, Wesley C

“…New therapeutics to combat malaria are desperately needed. Here we show that the enzyme protein farnesyltransferase (PFT) from the malaria parasite Plasmodium…”
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Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2) by Koduri, Rao S, Grönroos, Juha O, Laine, Veli J O, Le Calvez, Catherine, Lambeau, Gérard, Nevalainen, Timo J, Gelb, Michael H

“…Group IIA secreted phospholipase A(2) (sPLA2) is known to display potent Gram-positive bactericidal activity in vitro and in vivo. We have analyzed the…”
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Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha by Mounier, Carine M, Ghomashchi, Farideh, Lindsay, Margaret R, James, Scott, Singer, Alan G, Parton, Robert G, Gelb, Michael H

“…Stable expression of human groups IIA and X secreted phospholipases A(2) (hGIIA and hGX) in CHO-K1 and HEK293 cells leads to serum- and…”
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Parasitology. Drugs to combat tropical protozoan parasites by Gelb, Michael H, Hol, Wim G J

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The Protein Farnesyltransferase Inhibitor Tipifarnib as a New Lead for the Development of Drugs against Chagas Disease by Hucke, Oliver, Gelb, Michael H, Verlinde, Christophe L. M. J, Buckner, Frederick S

“…Tipifarnib (R115777), an inhibitor of human protein farnesyltransferase (PFT), is shown to be a highly potent inhibitor of Trypanosoma cruzi growth (ED50 = 4…”
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Exogenously added human group X secreted phospholipase A(2) but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells by Bezzine, S, Koduri, R S, Valentin, E, Murakami, M, Kudo, I, Ghomashchi, F, Sadilek, M, Lambeau, G, Gelb, M H

“…Mammalian secreted phospholipases A(2) (sPLA2s) comprise a group of at least eight enzymes, including the recently identified group X sPLA2. A bacterial…”
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Absolute Quantification of Specific Proteins in Complex Mixtures Using Visible Isotope-Coded Affinity Tags by Lu, Yu, Bottari, Patricia, Turecek, Frantisek, Aebersold, Ruedi, Gelb, Michael H

“…The identification of proteins in complex mixtures is most useful when quantitative information is also obtained. We describe a new type of protein tagging…”
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A Ruler for Determining the Position of Proteins in Membranes by Nielsen, Robert D, Che, Kepeng, Gelb, Michael H, Robinson, Bruce H

“…Both the oxygen diffusion rate and the oxygen solubility vary with depth into the interior of biological membranes. The product of these two gradients…”
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Translocation of the 85-kDa Phospholipase A from Cytosol to the Nuclear Envelope in Rat Basophilic Leukemia Cells Stimulated with Calcium Ionophore or IgE/Antigen by Sarah Glover, Timothy Bayburt, Mechthild Jonas, Emil Chi, Michael H. Gelb

“…The rat mast cell line RBL-2H3.1 contains an 85-kDa cytosolic phospholipase A 2 (cPLA 2 ) that is very likely involved in liberating arachidonate from membrane…”
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