Search Results - "Gelb, B"

Avelumab in metastatic urothelial carcinoma after platinum failure (JAVELIN Solid Tumor): pooled results from two expansion cohorts of an open-label, phase 1 trial by Patel, Manish R, Ellerton, John, Infante, Jeffrey R, Agrawal, Manish, Gordon, Michael, Aljumaily, Raid, Britten, Carolyn D, Dirix, Luc, Lee, Keun-Wook, Taylor, Mathew, Schöffski, Patrick, Wang, Ding, Ravaud, Alain, Gelb, Arnold B, Xiong, Junyuan, Rosen, Galit, Gulley, James L, Apolo, Andrea B

“…The approval of anti-programmed death ligand 1 (PD-L1) and anti-programmed death 1 agents has expanded treatment options for patients with locally advanced or…”
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Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome by Lacro, Ronald V, Dietz, Harry C, Sleeper, Lynn A, Yetman, Anji T, Bradley, Timothy J, Colan, Steven D, Pearson, Gail D, Selamet Tierney, E. Seda, Levine, Jami C, Atz, Andrew M, Benson, D. Woodrow, Braverman, Alan C, Chen, Shan, De Backer, Julie, Gelb, Bruce D, Grossfeld, Paul D, Klein, Gloria L, Lai, Wyman W, Liou, Aimee, Loeys, Bart L, Markham, Larry W, Olson, Aaron K, Paridon, Stephen M, Pemberton, Victoria L, Pierpont, Mary Ella, Pyeritz, Reed E, Radojewski, Elizabeth, Roman, Mary J, Sharkey, Angela M, Stylianou, Mario P, Wechsler, Stephanie Burns, Young, Luciana T, Mahony, Lynn

“…In this study, children and young adults with Marfan's syndrome were randomly assigned to receive atenolol or losartan and were followed for 3 years. There was…”
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Poly(trehalose methacrylate) as an Excipient for Insulin Stabilization: Mechanism and Safety by Gelb, Madeline B., Messina, Kathryn M. M., Vinciguerra, Daniele, Ko, Jeong Hoon, Collins, Jeffrey, Tamboline, Mikayla, Xu, Shili, Ibarrondo, F. Javier, Maynard, Heather D.

“…Insulin, the oldest U.S. Food and Drug Administration (FDA)-approved recombinant protein and a World Health Organization (WHO) essential medicine for treating…”
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Noonan Syndrome: Clinical Aspects and Molecular Pathogenesis by Tartaglia, M., Zampino, G., Gelb, B.D.

“…Noonan syndrome (NS) is a relatively common, clinically variable and genetically heterogeneous developmental disorder characterized by postnatally reduced…”
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Avelumab (anti-PD-L1) as first-line switch-maintenance or second-line therapy in patients with advanced gastric or gastroesophageal junction cancer: phase 1b results from the JAVELIN Solid Tumor trial by Chung, Hyun Cheol, Arkenau, Hendrik-Tobias, Lee, Jeeyun, Rha, Sun Young, Oh, Do-Youn, Wyrwicz, Lucjan, Kang, Yoon-Koo, Lee, Keun-Wook, Infante, Jeffrey R, Lee, Sung Sook, Kemeny, Margaret, Keilholz, Ulrich, Melichar, Bohuslav, Mita, Alain, Plummer, Ruth, Smith, Denis, Gelb, Arnold B, Xiong, Huiling, Hong, Janet, Chand, Vikram, Safran, Howard

“…We evaluated the antitumor activity and safety of avelumab, a human anti-PD-L1 IgG1 antibody, as first-line switch-maintenance (1 L-mn) or second-line (2 L)…”
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ORE identifies extreme expression effects enriched for rare variants by Richter, F, Hoffman, G E, Manheimer, K B, Patel, N, Sharp, A J, McKean, D, Morton, S U, DePalma, S, Gorham, J, Kitaygorodksy, A, Porter, G A, Giardini, A, Shen, Y, Chung, W K, Seidman, J G, Seidman, C E, Schadt, E E, Gelb, B D

“…Abstract Motivation Non-coding rare variants (RVs) may contribute to Mendelian disorders but have been challenging to study due to small sample sizes, genetic…”
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In vivo Target Modulation and Biological Activity of CHIR-258, a Multitargeted Growth Factor Receptor Kinase Inhibitor, in Colon Cancer Models by SANG HOON LEE, DE MENEZES, Daniel Lopes, HEISE, Carla, VORA, Jayesh, HARRIS, Alex, YE, Helen, NORDAHL, Lara, GARRETT, Evelyn, SAMARA, Emil, AUKERMAN, Sharon Lea, GELB, Arnold B

“…Purpose: To evaluate the therapeutic and biological effects of CHIR-258, an orally bioavailable, potent inhibitor of class III-V receptor tyrosine kinases, in…”
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Characterization of a Novel Recombinant Hyaluronan Binding Protein for Tissue Hyaluronan Detection by Jadin, Laurence, Huang, Lei, Wei, Ge, Zhao, Qiping, Gelb, Arnold B., Frost, Gregory I., Jiang, Ping, Shepard, H. Michael

“…Tumor necrosis factor-Stimulated Gene 6 protein (TSG-6) is a hyaluronan (HA)-binding glycoprotein containing an HA-binding Link module. Because of its…”
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Novel Donor Transfer Algorithm for Multiorgan and Facial Allograft Procurement by Diaz‐Siso, J. R., Plana, N. M., Schleich, B., Irving, H., Gelb, B. E., Rodriguez, E. D.

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Complex genetics and the etiology of human congenital heart disease by Gelb, Bruce D, Chung, Wendy K

“…Congenital heart disease (CHD) is the most common birth defect. Despite considerable advances in care, CHD remains a major contributor to newborn mortality and…”
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Helicobacter pylori Infection and Gastric Lymphoma by Parsonnet, Julie, Hansen, Svein, Rodriguez, Larissa, Gelb, Arnold B, Warnke, Roger A, Jellum, Egil, Orentreich, Norman, Vogelman, Joseph H, Friedman, Gary D

“…Primary non-Hodgkin's lymphoma of the stomach is an uncommon cancer, accounting for only 10 percent of lymphomas and 3 percent of gastric neoplasms 1 …”
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Repeat A2 Into B Kidney Transplantation After Failed Prior A2 Into B Transplant: A Case Report by Tatapudi, V.S., Min, E.S., Gelb, B.E., Dagher, N.N., Montgomery, R.A., Lonze, B.E.

“…Kidneys from donors with blood type A2 can be successfully transplanted into blood type B and O recipients without the need for desensitization if the…”
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PTPN11 analysis for the prenatal diagnosis of Noonan syndrome in fetuses with abnormal ultrasound findings by Lee, KA, Williams, B, Roza, K, Ferguson, H, David, K, Eddleman, K, Stone, J, Edelmann, L, Richard, G, Gelb, BD, Kornreich, R

“…Noonan syndrome (NS) is an autosomal dominant disorder characterized by short stature, congenital heart defects and distinctive facies. The disorder is…”
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Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency by Gelb, Bruce D., Shi, Guo-Ping, Chapman, Harold A., Desnick, Robert J.

“…Pycnodysostosis, an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature, maps to chromosome 1q21. Cathepsin K, a…”
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Phenotypic and genotypic characterisation of Noonan-like/multiple giant cell lesion syndrome by Lee, J S, Tartaglia, M, Gelb, B D, Fridrich, K, Sachs, S, Stratakis, C A, Muenke, M, Robey, P G, Collins, M T, Slavotinek, A

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Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis by Flex, Elisabetta, Jaiswal, Mamta, Pantaleoni, Francesca, Martinelli, Simone, Strullu, Marion, Fansa, Eyad K, Caye, Aurélie, De Luca, Alessandro, Lepri, Francesca, Dvorsky, Radovan, Pannone, Luca, Paolacci, Stefano, Zhang, Si-Cai, Fodale, Valentina, Bocchinfuso, Gianfranco, Rossi, Cesare, Burkitt-Wright, Emma M M, Farrotti, Andrea, Stellacci, Emilia, Cecchetti, Serena, Ferese, Rosangela, Bottero, Lisabianca, Castro, Silvana, Fenneteau, Odile, Brethon, Benoît, Sanchez, Massimo, Roberts, Amy E, Yntema, Helger G, Van Der Burgt, Ineke, Cianci, Paola, Bondeson, Marie-Louise, Cristina Digilio, Maria, Zampino, Giuseppe, Kerr, Bronwyn, Aoki, Yoko, Loh, Mignon L, Palleschi, Antonio, Di Schiavi, Elia, Carè, Alessandra, Selicorni, Angelo, Dallapiccola, Bruno, Cirstea, Ion C, Stella, Lorenzo, Zenker, Martin, Gelb, Bruce D, Cavé, Hélène, Ahmadian, Mohammad R, Tartaglia, Marco

“…RASopathies, a family of disorders characterized by cardiac defects, defective growth, facial dysmorphism, variable cognitive deficits and predisposition to…”
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Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus by Pierpont, Mary Ella M, Satoda, Masahiko, Gelb, Bruce D, Goodship, Judith, Burn, John, Diaz, George A, Davidson, H. Rosemarie, Zhao, Feng

“…Char syndrome is an autosomal dominant trait characterized by patent ductus arteriosus, facial dysmorphism and hand anomalies. Using a positional candidacy…”
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Noonan syndrome and related disorders: genetics and pathogenesis by Tartaglia, Marco, Gelb, Bruce D

“…Noonan syndrome is a pleiomorphic autosomal dominant disorder with short stature, facial dysmorphia, webbed neck, and heart defects. In the past decade,…”
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CBFA1 Mutation Analysis and Functional Correlation with Phenotypic Variability in Cleidocranial Dysplasia by Zhou, Guang, Chen, Yuqing, Zhou, Lei, Thirunavukkarasu, Kannan, Hecht, Jacqueline, Chitayat, David, Gelb, Bruce D., Pirinen, Sinikka, Berry, Susan A., Greenberg, Cheryl R., Karsenty, Gerard, Lee, Brendan

“…Cleidocranial dysplasia (CCD) is a dominantly inherited skeletal dysplasia caused by mutations in the osteoblast-specific transcription factor CBFA1. To…”
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Avelumab, an Anti-Programmed Death-Ligand 1 Antibody, In Patients With Refractory Metastatic Urothelial Carcinoma: Results From a Multicenter, Phase Ib Study by Apolo, Andrea B, Infante, Jeffrey R, Balmanoukian, Ani, Patel, Manish R, Wang, Ding, Kelly, Karen, Mega, Anthony E, Britten, Carolyn D, Ravaud, Alain, Mita, Alain C, Safran, Howard, Stinchcombe, Thomas E, Srdanov, Marko, Gelb, Arnold B, Schlichting, Michael, Chin, Kevin, Gulley, James L

“…Purpose We assessed the safety and antitumor activity of avelumab, a fully human anti-programmed death-ligand 1 (PD-L1) IgG1 antibody, in patients with…”
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