Search Results - "Geist, Marcus"

Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients by Geist, Marcus J. P., Ziesenitz, Victoria C., Bardenheuer, Hubert J., Burhenne, Juergen, Skopp, Gisela, Mikus, Gerd

“…Transdermal fentanyl is widely used to control pain in cancer patients. The high pharmacokinetic variability of fentanyl is assumed to be due to cytochrome…”
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Decreased Cytochrome P450 3A activity in palliative patients with haematological diseases: Potential impact on supportive drug therapies by Geist, Marcus J. P., Siller, Nelly, Egerer, Gerlinde, Bardenheuer, Hubert, Burhenne, Juergen, Mikus, Gerd

“…Cytochrome P450 3A (CYP3A) is the most relevant drug‐metabolizing enzyme in human beings involved in the elimination of about 50% of the marketed drugs…”
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Steady-state pharmacokinetics and metabolism of voriconazole in patients by Geist, Marcus J P, Egerer, Gerlinde, Burhenne, Jürgen, Riedel, Klaus-Dieter, Weiss, Johanna, Mikus, Gerd

“…Voriconazole exhibits non-linear pharmacokinetics in adults and is said to be mainly metabolized by CYP2C19 and CYP3A4 to voriconazole-N-oxide. The aim of this…”
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Impact of patient education on plasma concentrations and effectiveness of posaconazole oral suspension under clinical conditions by Geist, Marcus J. P., Egerer, Gerlinde, Mikus, Gerd, Blank, Antje, Hohmann, Nicolas, Heinz, Werner J., Carls, Alexandra

“…Posaconazole prophylaxis is recommended for patients with acute myeloid leukaemia during induction chemotherapy. Although a tablet formulation with better oral…”
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Bleeding Control in Palliative Care Patients With the Help of Tranexamic Acid by Geist, Marcus J. P., Kessler, Jens, Frankenhauser, Susanne, Bardenheuer, Hubert J.

“…Background: Persistent bleeding is a common reason for admitting patients with advanced cancer to a palliative care unit. Several reports show a successful…”
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In Vivo CYP3A Activity in Palliative Care Patients: Study Protocol for a Single Arm Prospective Trial by Geist, Marcus J P, Bardenheuer, Hubert J, Burhenne, Jürgen, Mikus, Gerd

“…Drug interactions are a common cause for escalation of debilitating symptoms in palliative care patients. CYP3A is the most relevant CYP enzyme in humans…”
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Induction of voriconazole metabolism by rifampin in a patient with acute myeloid leukemia: importance of interdisciplinary communication to prevent treatment errors with complex medications by Geist, Marcus J P, Egerer, Gerlinde, Burhenne, Jürgen, Riedel, Klaus-Dieter, Mikus, Gerd

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Safety of voriconazole in a patient with CYP2C92/CYP2C92 genotype by Geist, Marcus J P, Egerer, Gerlinde, Burhenne, Jürgen, Mikus, Gerd

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Stream temperature data collection standards for Alaska: Minimum standards to generate data useful for regional-scale analyses by Mauger, Sue, Shaftel, Rebecca, Trammell, E. Jamie, Geist, Marcus, Bogan, Dan

“…Statewide interest in thermal patterns and increasing data collection efforts provides Alaska’s scientific and resource management communities an opportunity…”
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Alteration of drug-metabolizing enzyme activity in palliative care patients: Microdosed assessment of cytochrome P450 3A by Geist, Marcus, Bardenheuer, Hubert, Burhenne, Juergen, Mikus, Gerd

“…Background: Cytochrome P450 3A is the most relevant drug-metabolizing enzyme in humans as it is involved in the elimination of 50% of marketed drugs. Nothing…”
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Treatment-Refractory Pain by Keßler, Jens, Geist, Marcus, Bardenheuer, Hubert

“…Pain therapy concepts should be based on a biopsychosocial model. A prerequisite for adequate pain therapy is the detailed medical history. The questions about…”
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Bleeding Control in Palliative Care Patients With the Help of Tranexamic Acid by Geist, Marcus J P, Kessler, Jens, Frankenhauser, Susanne, Bardenheuer, Hubert J

“…BACKGROUNDPersistent bleeding is a common reason for admitting patients with advanced cancer to a palliative care unit. Several reports show a successful…”
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