Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study

Respiratory tract infections (RTIs) are a major morbidity factor contributing largely to health care costs and individual quality of life. The aim of the study was to test whether obesity (BMI ≥ 30 kg/m ) is one of the risk factors underlying frequent RTIs in the German adult population. We recruite...

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Bibliographic Details
Published in:	BMC public health Vol. 18; no. 1; p. 271
Main Authors:	Maccioni, Livia, Weber, Susanne, Elgizouli, Magdeldin, Stoehlker, Anne-Sophie, Geist, Ilona, Peter, Hans-Hartmut, Vach, Werner, Nieters, Alexandra
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 20-02-2018 BioMed Central BMC
Subjects:	Adolescent Adult Adult respiratory tract infections Adults Aged Antibiotics Asthma Body mass index Bronchitis Cohort analysis Cohort Studies Community Complications and side effects Cross-Sectional Studies Demographic variables Demographics Diaries Diary Ear diseases Effect modification Exercise Female Gender Germany - epidemiology Humans Illnesses Immunology Infections Influenza Life style factors Male Medical research Middle Aged Morbidity Obesity Obesity - epidemiology Physical fitness Pneumonia Population Public health Quality of life Respiratory tract Respiratory tract diseases Respiratory tract infection Respiratory tract infections Respiratory Tract Infections - epidemiology Risk analysis Risk Factors Seasons Self Report Statistical analysis Studies Systematic review Tonsillitis Viral infections Young Adult Germany Effect modification Obesity Life style factors Diary Adult respiratory tract infections
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Summary:	Respiratory tract infections (RTIs) are a major morbidity factor contributing largely to health care costs and individual quality of life. The aim of the study was to test whether obesity (BMI ≥ 30 kg/m ) is one of the risk factors underlying frequent RTIs in the German adult population. We recruited 1455 individuals between 18 to 70 years from a cross-sectional survey on airway infections in Germany and invited them to self-report in diaries incident RTIs experienced during three consecutive winter/spring seasons. RTIs reported in these 18 months and summary measures adding-up individual RTIs were the outcomes of interest. Compared to individuals with normal weight, obese individuals reported a consistently higher frequency of upper and lower RTIs and predominantly fell in the upper 10% group of a diary sumscore adding-up 10 different RTI symptoms over time. Obesity was associated both with lower RTIs ( OR = 2.02, 95%CI = 1.36-3.00) and upper RTIs ( OR = 1.55, 95%CI = 1.22-1.96). Adjusting for demographic and lifestyle variables did only marginally affect ORs. Stratified analyses suggested a stronger association for women and effect modifications by sports activity and dietary habits. We confirm the association of obesity with infection burden and present evidence for putative interaction with sports activity and dietary patterns.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1471-2458 1471-2458
DOI:	10.1186/s12889-018-5172-8