Search Results - "Geissler, E.K."

Global Transplantation COVID Report March 2020 by Ahn, C., Amer, H., Anglicheau, D., Ascher, N.L., Baan, C.C., Battsetset, G., Bat-Ireedui, B., Berney, T., Betjes, M.G.H., Bichu, S., Birn, H., Brennan, D., Bromberg, J., Caillard, S., Cannon, R.M., Cantarovich, M., Chan, A., Chen, Z.S., Chapman, J.R., Cole, E.H., Cross, N., Durand, F., Egawa, H., Emond, J.C., Farrero, M., Friend, P.J., Geissler, E.K., Ha, J., Haberal, M.A., Henderson, M.L., Hesselink, D.A., Humar, A., Jassem, W., Jeong, J.C., Kaplan, B., Kee, T., Kim, S.J., Kumar, D., Legendre, C.M., Man, K., Moulin, B., Muller, E., Munkhbat, R., Od-Erdene, L., Perrin, P., Rela, M., Tanabe, K., Tedesco Silva, H., Tinckam, K.T., Tullius, S.G., Wong, G.

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Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate by Popp, F.C, Eggenhofer, E, Renner, P, Slowik, P, Lang, S.A, Kaspar, H, Geissler, E.K, Piso, P, Schlitt, H.J, Dahlke, M.H

“…Abstract The induction of tolerance towards allogeneic solid organ grafts is one of the major goals in transplantation medicine. Mesenchymal stem cells (MSC)…”
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Sirolimus use in liver transplant recipients with hepatocellular carcinoma: A randomized, multi-centre, open-label phase 3 trial – The SiLVER-study by Schnitzbauer, A, Schlitt, H.J, Geissler, E.K

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Mesenchymal Stem Cells Require a Sufficient, Ongoing Immune Response to Exert Their Immunosuppressive Function by Renner, P, Eggenhofer, E, Rosenauer, A, Popp, F.C, Steinmann, J.F, Slowik, P, Geissler, E.K, Piso, P, Schlitt, H.J, Dahlke, M.H

“…Abstract Mesenchymal stem cells (MSC) have emerged to be one of the most promising candidates for cellular immunotherapy in solid organ transplantation because…”
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Can Immunosuppressive Strategies Be Used to Reduce Cancer Risk in Renal Transplant Patients? by Geissler, E.K

“…Abstract The risk of renal transplant recipients developing a malignancy is increasingly recognized as a major issue impacting long-term overall survival. As…”
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Mesenchymal stem cells together with mycophenolate mofetil inhibit antigen presenting cell and T cell infiltration into allogeneic heart grafts by Eggenhofer, E, Steinmann, J.F, Renner, P, Slowik, P, Piso, P, Geissler, E.K, Schlitt, H.J, Dahlke, M.H, Popp, F.C

“…Abstract Donor-derived mesenchymal stem cells (MSC) can induce long-term acceptance in a rat heart transplantation model when injected prior to transplantation…”
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The Impact of mTOR Inhibitors on the Development of Malignancy by Geissler, E.K

“…Abstract Although continuous improvements have been made in fighting rejection with immunosuppressive drugs in transplant recipients, this success story has…”
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VEGF: A Surrogate Marker for Peripheral Vascular Disease by Stehr, A, Töpel, I, Müller, S, Unverdorben, K, Geissler, E.K, Kasprzak, P.M, Schlitt, H.J, Steinbauer, M

“…Abstract This study aims to evaluate the value of VEGF as a surrogate marker for peripheral vascular disease (PVD). Prior to treatment, serum VEGF levels were…”
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Fighting Malignancy in Organ Transplant Recipients by Geissler, E.K

“…Abstract The development of malignancy in immunosuppressed organ transplant recipients has recently gained increasing attention. Increased awareness of this…”
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Relevance of maintenance triple-drug immunosuppression to bridle the amplification of rat cytomegalovirus infection after experimental lung transplantation by Lehle, K., von Suesskind-Schwendi, M., Diez, C., Michl, M., Geissler, E.K., Wottge, H.U., Schmid, C., Hirt, S.W.

“…Immunosuppressive therapy required to treat rejection after lung transplantation (LTx) contributes significantly to the pathogenesis of cytomegalovirus (CMV)…”
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Antigen-specific recognition is critical for the function of regulatory CD8+ CD28− T cells by Renner, P, Popp, F.C, Eggenhofer, E, Slowik, P, Piso, P, Geissler, E.K, Schlitt, H.J, Dahlke, M.H

“…Abstract The immunomodulatory properties of CD8 T cells with regulatory phenotype have become evident. It remains unclear whether the immunomodulatory function…”
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Basophils Trigger Fibroblast Activation in Cardiac Allograft Fibrosis Development by Schiechl, G., Hermann, F. J., Rodriguez Gomez, M., Kutzi, S., Schmidbauer, K., Talke, Y., Neumayer, S., Goebel, N., Renner, K., Brühl, H., Karasuyama, H., Obata‐Ninomiya, K., Utpatel, K., Evert, M., Hirt, S. W., Geissler, E. K., Fichtner‐Feigl, S., Mack, M.

“…Fibrosis is a major component of chronic cardiac allograft rejection. Although several cell types are able to produce collagen, resident (donor‐derived)…”
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Cyclosporine A Inhibits the T‐bet–Dependent Antitumor Response of CD8+ T Cells by Rovira, J., Renner, P., Sabet‐Baktach, M., Eggenhofer, E., Koehl, G. E., Lantow, M., Lang, S. A., Schlitt, H. J., Campistol, J. M., Geissler, E. K., Kroemer, A.

“…Transplant recipients face an increased risk of cancer compared with the healthy population. Although several studies have examined the direct effects of…”
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Inhibition of Innate Co‐Receptor TREM‐1 Signaling Reduces CD4+ T Cell Activation and Prolongs Cardiac Allograft Survival by Schiechl, G., Brunner, S. M., Kesselring, R., Martin, M., Ruemmele, P., Mack, M., Hirt, S. W., Schlitt, H. J., Geissler, E. K., Fichtner‐Feigl, S.

“…The innate receptor “triggering‐receptor‐expressed‐on‐myeloid‐cells‐1” (TREM‐1) enhances downstream signaling of “pattern recognition receptor” (PRR) molecules…”
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Early and late effects of the immunosuppressants rapamycin and mycophenolate mofetil on UV carcinogenesis by de Gruijl, F.R., Koehl, G.E., Voskamp, P., Strik, A., Rebel, H.G., Gaumann, A., de Fijter, J.W., Tensen, C.P., Bavinck, J.N. Bouwes, Geissler, E.K.

“…Increased skin cancer risk in organ transplant recipients has been experimentally emulated with enhanced UV carcinogenesis from administering conventional…”
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Experimental Surgery: Providing conditions to optimise the future of surgeon-scientists by Geissler, E.K.

“…Summary Fostering the development of a successful and respected surgical researcher first requires an absolute devotion from the individual to achieve this…”
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Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in [APC.sup.Min/+] mice by Koehl, G.E, Spitzner, M, Ousingsawat, J, Schreiber, R, Geissler, E.K, Kunzelmann, K

“…The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis. Mice with a heterozygous [APC.sup.Min] mutation develop multiple…”
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Hepatocellular carcinoma progression during bridging before liver transplantation by Renner, P, Da Silva, T, Schnitzbauer, A A, Verloh, N, Schlitt, H J, Geissler, E K

“…Abstract Background Recipient selection for liver transplantation in hepatocellular carcinoma (HCC) is based primarily on criteria affecting the chance of…”
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Rapamycin impairs UV induction of mutant-p53 overexpressing cell clusters without affecting tumor onset by Voskamp, P., Bodmann, C.A., Rebel, H.G., Koehl, G.E., Tensen, C.P., Bouwes Bavinck, J.N., El Ghalbzouri, A., Van Kranen, H.J., Willemze, R., Geissler, E.K., De Gruijl, F.R.

“…Because of its antitumor effect, the immunosuppressant rapamycin holds great promise for organ transplant recipients in that it may lower their cancer risk. In…”
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Preferential migration of CD62L cells into the appendix in mice with experimental chronic colitis by Farkas, S A, Hornung, M, Sattler, Christine, Steinbauer, M, Anthuber, M, Obermeier, F, Herfarth, H, Schlitt, H J, Geissler, E K

“…Clinical and experimental studies suggest that appendectomy can protect against development of ulcerative colitis and Crohn's disease. However, how T cells in…”
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