Search Results - "Geiss, William"

Design, Synthesis, and Structure−Activity Relationships of Novel 2-Substituted Pyrazinoylguanidine Epithelial Sodium Channel Blockers:  Drugs for Cystic Fibrosis and Chronic Bronchitis by Hirsh, Andrew J, Molino, Bruce F, Zhang, Jianzhong, Astakhova, Nadezhda, Geiss, William B, Sargent, Bruce J, Swenson, Brian D, Usyatinsky, Alexander, Wyle, Michael J, Boucher, Richard C, Smith, Rick T, Zamurs, Andra, Johnson, M. Ross

“…Amiloride (1), the prototypical epithelial sodium channel (ENaC) blocker, has been administered with limited success as aerosol therapy for improving pulmonary…”
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Synthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors by Alstermark, Christer, Amin, Kosrat, Dinn, Sean R, Elebring, Thomas, Fjellström, Ola, Fitzpatrick, Kevin, Geiss, William B, Gottfries, Johan, Guzzo, Peter R, Harding, James P, Holmén, Anders, Kothare, Mohit, Lehmann, Anders, Mattsson, Jan P, Nilsson, Karolina, Sundén, Gunnel, Swanson, Marianne, von Unge, Sverker, Woo, Alex M, Wyle, Michael J, Zheng, Xiaozhang

“…We have previously demonstrated that the prototypical GABAB receptor agonist baclofen inhibits transient lower esophageal sphincter relaxations (TLESRs), the…”
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Synthesis and SAR development of novel P2X₇ receptor antagonists for the treatment of pain: Part 2 by Brumfield, Stephanie, Matasi, Julius J, Tulshian, Deen, Czarniecki, Michael, Greenlee, William, Garlisi, Charles, Qiu, Hongchen, Devito, Kristine, Chen, Shu-Cheng, Sun, Yongliang, Bertorelli, Rosalia, Ansell, Justin, Geiss, William, Le, Van-Duc, Martin, Gregory S, Vellekoop, Samuel A, Haber, James, Allard, Melissa L

“…Novel P2X₇ antagonists were developed using a purine scaffold. These compounds were potent and selective at the P2X₇ receptor in human and rodent as well as…”
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Effects of (2R)‐(3‐amino‐2‐fluoropropyl)sulphinic acid (AFPSiA) on transient lower oesophageal sphincter relaxation in dogs and mechanism of hypothermic effects in mice by Lehmann, Anders, Holmberg, Ann Aurell, Bhatt, Ulhas, Bremner‐Danielsen, Marianne, Brändén, Lena, Elg, Susanne, Elebring, Thomas, Fitzpatrick, Kevin, Geiss, William B, Guzzo, Peter, Jensen, Jorgen, Jerndal, Gunilla, Mattsson, Jan P, Nilsson, Karolina, Olsson, Britt‐Marie

“…The effects of the novel GABA analogue (2R)‐(3‐amino‐2‐fluoropropyl)sulphinic acid (AFPSiA) on transient lower oesophageal sphincter relaxations (TLOSRs) were…”
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A Stereospecific Synthesis of 24(S)-Hydroxyvitamin D2, a Prodrug for 1α,24(S)-Dihydroxyvitamin D2 by Coutts, Lisa D, Geiss, William B, Gregg, Brian T, Helle, Mark A, King, Chi-Hsin R, Itov, Zinovy, Mateo, Mary E, Meckler, Harold, Zettler, Mark W, Knutson, Joyce C

“…This contribution describes the first stereospecific synthesis of 24(S)-hydroxyvitamin D2 (1), a metabolite of vitamin D2. This metabolite acts as a prodrug…”
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Synthesis and SAR development of novel P2X 7 receptor antagonists for the treatment of pain: Part 1 by Matasi, Julius J., Brumfield, Stephanie, Tulshian, Deen, Czarnecki, Michael, Greenlee, William, Garlisi, Charles G., Qiu, Hongchen, Devito, Kristine, Chen, Shu-Cheng, Sun, Youngliang, Bertorelli, Rosalia, Geiss, William, Le, Van-Duc, Martin, Gregory S., Vellekoop, Samuel A., Haber, James, Allard, Melissa L.

“…Structure–activity relationship (SAR) efforts around our initial lead compound 1 led to the identification of potent P2X 7 receptor antagonists with improved…”
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Synthesis and SAR development of novel P2X sub(7 receptor antagonists for the treatment of pain: Part 1) by Matasi, Julius J, Brumfield, Stephanie, Tulshian, Deen, Czarnecki, Michael, Greenlee, William, Garlisi, Charles G, Qiu, Hongchen, Devito, Kristine, Chen, Shu-Cheng, Sun, Youngliang, Bertorelli, Rosalia, Geiss, William, Le, Van-Duc, Martin, Gregory S, Vellekoop, Samuel A, Haber, James, Allard, Melissa L

“…Structure-activity relationship (SAR) efforts around our initial lead compound 1 led to the identification of potent P2X sub(7 receptor antagonists with…”
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Synthesis and SAR development of novel P2X₇ receptor antagonists for the treatment of pain: Part 1 by Matasi, Julius J, Brumfield, Stephanie, Tulshian, Deen, Czarnecki, Michael, Greenlee, William, Garlisi, Charles G, Qiu, Hongchen, Devito, Kristine, Chen, Shu-Cheng, Sun, Youngliang, Bertorelli, Rosalia, Geiss, William, Le, Van-Duc, Martin, Gregory S, Vellekoop, Samuel A, Haber, James, Allard, Melissa L

“…Structure–activity relationship (SAR) efforts around our initial lead compound 1 led to the identification of potent P2X₇ receptor antagonists with improved…”
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Synthesis and SAR development of novel P2X 7 receptor antagonists for the treatment of pain: Part 2 by Brumfield, Stephanie, Matasi, Julius J., Tulshian, Deen, Czarniecki, Michael, Greenlee, William, Garlisi, Charles, Qiu, Hongchen, Devito, Kristine, Chen, Shu-Cheng, Sun, Yongliang, Bertorelli, Rosalia, Ansell, Justin, Geiss, William, Le, Van-Duc, Martin, Gregory S., Vellekoop, Samuel A., Haber, James, Allard, Melissa L.

“…Novel P2X 7 antagonists were developed using a purine scaffold. These compounds were potent and selective at the P2X 7 receptor in human and rodent as well as…”
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A Stereospecific Synthesis of 24( S )-Hydroxyvitamin D 2 , a Prodrug for 1α,24( S )-Dihydroxyvitamin D 2 by Coutts, Lisa D., Geiss, William B., Gregg, Brian T., Helle, Mark A., King, Chi-Hsin R., Itov, Zinovy, Mateo, Mary E., Meckler, Harold, Zettler, Mark W., Knutson, Joyce C.

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Effect of triplet-state sensitization on inter- and intramolecular 2+2 photocycloadditions of 2,5-cyclohexadien-1-ones by Schultz, Arthur G, Geiss, William

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The regio- and diastereoselectivity of the intramolecular 2 + 2 photocycloadditions of 4-(2'-isopropyl-3'-butenyl)-2,5-cyclohexadien-1-ones by Schultz, Arthur G, Geiss, William, Kullnig, Rudolph K

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