Search Results - "Geis, Christian"

Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System by Dalmau, Josep, Geis, Christian, Graus, Francesc

“…Investigations in the last 10 years have revealed a new category of neurological diseases mediated by antibodies against cell surface and synaptic proteins…”
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Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation? by Bircak-Kuchtova, Barbora, Chung, Ha-Yeun, Wickel, Jonathan, Ehler, Johannes, Geis, Christian

“…Sepsis is the most common cause of admission to intensive care units worldwide. Sepsis patients frequently suffer from sepsis-associated encephalopathy (SAE)…”
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Molecular mimicry of NMDA receptors may contribute to neuropsychiatric symptoms in severe COVID-19 cases by Vasilevska, Veronika, Guest, Paul C, Bernstein, Hans-Gert, Schroeter, Matthias L, Geis, Christian, Steiner, Johann

“…Abstract Approximately 30% of individuals with severe SARS-CoV-2 infections also develop neurological and psychiatric complaints. In rare cases, the occurrence…”
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Multitemporal Relearning With Convolutional LSTM Models for Land Use Classification by Zhu, Yue, Geis, Christian, So, Emily, Jin, Ying

“…In this article, we present a novel hybrid framework, which integrates spatial-temporal semantic segmentation with postclassification relearning, for…”
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Disaster Intensity-Based Selection of Training Samples for Remote Sensing Building Damage Classification by Moya, Luis, Geis, Christian, Hashimoto, Masakazu, Mas, Erick, Koshimura, Shunichi, Strunz, Gunter

“…Previous applications of machine learning in remote sensing for the identification of damaged buildings in the aftermath of a large-scale disaster have been…”
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Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction by Haselmann, Holger, Mannara, Francesco, Werner, Christian, Planagumà, Jesús, Miguez-Cabello, Federico, Schmidl, Lars, Grünewald, Benedikt, Petit-Pedrol, Mar, Kirmse, Knut, Classen, Joseph, Demir, Fatih, Klöcker, Nikolaj, Soto, David, Doose, Sören, Dalmau, Josep, Hallermann, Stefan, Geis, Christian

“…AMPA receptors are essential for fast excitatory transmission in the CNS. Autoantibodies to AMPA receptors have been identified in humans with autoimmune…”
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Bioorthogonal Click Chemistry Enables Site‐specific Fluorescence Labeling of Functional NMDA Receptors for Super‐Resolution Imaging by Neubert, Franziska, Beliu, Gerti, Terpitz, Ulrich, Werner, Christian, Geis, Christian, Sauer, Markus, Doose, Sören

“…Super‐resolution microscopy requires small fluorescent labels. We report the application of genetic code expansion in combination with bioorthogonal click…”
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Activation of TRPV1 Contributes to Morphine Tolerance: Involvement of the Mitogen-Activated Protein Kinase Signaling Pathway by Chen, Yong, Geis, Christian, Sommer, Claudia

“…Tolerance to the analgesic effects of opioids occurs after their chronic administration, a pharmacological phenomenon that has been associated with the…”
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Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis by Mein, Nils, von Stackelberg, Nikolai, Wickel, Jonathan, Geis, Christian, Chung, Ha-Yeun

“…Abstract Background Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concentration,…”
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Ephrin-B2 prevents N-methyl-D-aspartate receptor antibody effects on memory and neuroplasticity by Planagumà, Jesús, Haselmann, Holger, Mannara, Francesco, Petit-Pedrol, Mar, Grünewald, Benedikt, Aguilar, Esther, Röpke, Luise, Martín-García, Elena, Titulaer, Maarten J., Jercog, Pablo, Graus, Francesc, Maldonado, Rafael, Geis, Christian, Dalmau, Josep

“…Objective To demonstrate that ephrin‐B2 (the ligand of EphB2 receptor) antagonizes the pathogenic effects of patients' N‐methyl‐D‐aspartate receptor (NMDAR)…”
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Persistent neurocognitive deficits in cognitively impaired survivors of sepsis are explained by reductions in working memory capacity by Kattlun, Fabian, Hertel, Elizabeth, Geis, Christian, Scherag, André, Wickel, Jonathan, Finke, Kathrin

“…Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Mounting evidence suggests that many cognitively…”
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Glycine Receptor Autoantibodies Impair Receptor Function and Induce Motor Dysfunction by Rauschenberger, Vera, von Wardenburg, Niels, Schaefer, Natascha, Ogino, Kazutoyo, Hirata, Hiromi, Lillesaar, Christina, Kluck, Christoph J., Meinck, Hans‐Michael, Borrmann, Marc, Weishaupt, Andreas, Doppler, Kathrin, Wickel, Jonathan, Geis, Christian, Sommer, Claudia, Villmann, Carmen

“…Objective Impairment of glycinergic neurotransmission leads to complex movement and behavioral disorders. Patients harboring glycine receptor autoantibodies…”
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Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony by Ceanga, Mihai, Rahmati, Vahid, Haselmann, Holger, Schmidl, Lars, Hunter, Daniel, Brauer, Anna-Katherina, Liebscher, Sabine, Kreye, Jakob, Prüss, Harald, Groc, Laurent, Hallermann, Stefan, Dalmau, Josep, Ori, Alessandro, Heckmann, Manfred, Geis, Christian

“…Anti-NMDA receptor autoantibodies (NMDAR-Abs) in patients with NMDAR encephalitis cause severe disease symptoms resembling psychosis and cause cognitive…”
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Protecting RNA quality for spatial transcriptomics while improving immunofluorescent staining quality by Hahn, Nina, Bens, Martin, Kempfer, Marin, Reißig, Christin, Schmidl, Lars, Geis, Christian

“…In comparison to bulk sequencing or single cell sequencing, spatial transcriptomics preserves the spatial information in tissue slices and can even be mapped…”
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Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration by Kleinschnitz, Christoph, Grund, Henrike, Wingler, Kirstin, Armitage, Melanie E, Jones, Emma, Mittal, Manish, Barit, David, Schwarz, Tobias, Geis, Christian, Kraft, Peter, Barthel, Konstanze, Schuhmann, Michael K, Herrmann, Alexander M, Meuth, Sven G, Stoll, Guido, Meurer, Sabine, Schrewe, Anja, Becker, Lore, Gailus-Durner, Valérie, Fuchs, Helmut, Klopstock, Thomas, de Angelis, Martin Hrabé, Jandeleit-Dahm, Karin, Shah, Ajay M, Weissmann, Norbert, Schmidt, Harald H H W

“…Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of…”
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µPhos: a scalable and sensitive platform for high-dimensional phosphoproteomics by Oliinyk, Denys, Will, Andreas, Schneidmadel, Felix R, Böhme, Maximilian, Rinke, Jenny, Hochhaus, Andreas, Ernst, Thomas, Hahn, Nina, Geis, Christian, Lubeck, Markus, Raether, Oliver, Humphrey, Sean J, Meier, Florian

“…Mass spectrometry has revolutionized cell signaling research by vastly simplifying the analysis of many thousands of phosphorylation sites in the human…”
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Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature by Jarius, Sven, Bräuninger, Stefan, Chung, Ha-Yeun, Geis, Christian, Haas, Jürgen, Komorowski, Lars, Wildemann, Brigitte, Roth, Christian

“…Abstract Background In 2014, we first described novel autoantibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1-IgG/anti-Sj) in patients with…”
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A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration by Weiler, Simon, Rahmati, Vahid, Isstas, Marcel, Wutke, Johann, Stark, Andreas Walter, Franke, Christian, Graf, Jürgen, Geis, Christian, Witte, Otto W., Hübener, Mark, Bolz, Jürgen, Margrie, Troy W., Holthoff, Knut, Teichert, Manuel

“…Tactile sensation and vision are often both utilized for the exploration of objects that are within reach though it is not known whether or how these two…”
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N‐methyl‐D‐aspartate receptor dysfunction by unmutated human antibodies against the NR1 subunit by Wenke, Nina Kerstin, Kreye, Jakob, Andrzejak, Ewa, Casteren, Adriana, Leubner, Jonas, Murgueitio, Manuela S., Reincke, S. Momsen, Secker, Christopher, Schmidl, Lars, Geis, Christian, Ackermann, Frauke, Nikolaus, Marc, Garner, Craig C., Wardemann, Hedda, Wolber, Gerhard, Prüss, Harald

“…Anti–N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis related to autoantibody‐mediated synaptic dysfunction…”
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Generate-Boost: study protocol for a prospective, multicenter, randomized controlled, double-blinded phase II trial to evaluate efficacy and safety of bortezomib in patients with severe autoimmune encephalitis by Wickel, Jonathan, Chung, Ha-Yeun, Platzer, Stephanie, Lehmann, Thomas, Prüss, Harald, Leypoldt, Frank, Günther, Albrecht, Scherag, André, Geis, Christian

“…Autoimmune encephalitis is a new spectrum of autoimmune disorders of the central nervous system (CNS), which are characterized by pathogenic autoantibodies…”
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