Search Results - "Geinisman, Yuri"

Synapse Distribution Suggests a Two-Stage Model of Dendritic Integration in CA1 Pyramidal Neurons by Katz, Yael, Menon, Vilas, Nicholson, Daniel A., Geinisman, Yuri, Kath, William L., Spruston, Nelson

“…Competing models have been proposed to explain how neurons integrate the thousands of inputs distributed throughout their dendritic trees. In a simple global…”
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Axospinous synaptic subtype-specific differences in structure, size, ionotropic receptor expression, and connectivity in apical dendritic regions of rat hippocampal CA1 pyramidal neurons by Nicholson, Daniel A., Geinisman, Yuri

“…The morphology of axospinous synapses and their parent spines varies widely. Additionally, many of these synapses are contacted by multiple synapse boutons…”
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Reduction in Size of Perforated Postsynaptic Densities in Hippocampal Axospinous Synapses and Age-Related Spatial Learning Impairments by Nicholson, Daniel A, Yoshida, Rie, Berry, Robert W, Gallagher, Michela, Geinisman, Yuri

“…A central problem in the neurobiology of normal aging is why learning is preserved in some aged individuals yet impaired in others. To investigate this issue,…”
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Differences in the expression of AMPA and NMDA receptors between axospinous perforated and nonperforated synapses are related to the configuration and size of postsynaptic densities by Ganeshina, Olga, Berry, Robert W., Petralia, Ronald S., Nicholson, Daniel A., Geinisman, Yuri

“…Axospinous synapses are traditionally divided according to postsynaptic density (PSD) configuration into a perforated subtype characterized by a complex‐shaped…”
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Associative Learning Elicits the Formation of Multiple-Synapse Boutons by Geinisman, Yuri, Berry, Robert W, Disterhoft, John F, Power, John M, Van der Zee, Eddy A

“…The formation of new synapses has been suggested to underlie learning and memory. However, previous work from this laboratory has demonstrated that…”
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Structural Synaptic Modifications Associated with Hippocampal LTP and Behavioral Learning by Geinisman, Y

“…An important problem in the neurobiology of memory is whether cellular mechanisms of learning and memory include the formation of new synapses or the…”
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Age-dependent alterations in hippocampal synaptic plasticity: relation to memory disorders by deToledo-Morrell, L, Geinisman, Y, Morrell, F

“…In this paper, we review the evidence indicating that the common disturbance in recent memory associated with aging is a consequence of functional and…”
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Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory by Geinisman, Y, de Toledo-Morrell, L, Morrell, F

“…Spatial working memory, which crucially depends on the structural integrity of the hippocampal formation and its afferent connections, is impaired in the most,…”
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Comparison of structural synaptic modifications induced by long-term potentiation in the hippocampal dentate gyrus of young adult and aged rats by Geinisman, Y, deToledo-Morrell, L, Morrell, F

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Synaptic strength and postsynaptically silent synapses through advanced aging in rat hippocampal CA1 pyramidal neurons by Sametsky, Evgeny A, Disterhoft, John F, Geinisman, Yuri, Nicholson, Daniel A

“…Abstract Synaptic dysfunction is thought to contribute to age-related learning impairments. Detailed information regarding the presence of silent synapses and…”
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Distance-Dependent Differences in Synapse Number and AMPA Receptor Expression in Hippocampal CA1 Pyramidal Neurons by Nicholson, Daniel A., Trana, Rachel, Katz, Yael, Kath, William L., Spruston, Nelson, Geinisman, Yuri

“…The ability of synapses throughout the dendritic tree to influence neuronal output is crucial for information processing in the brain. Synaptic potentials…”
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Perforated axospinous synapses with multiple, completely partitioned transmission zones: probable structural intermediates in synaptic plasticity by Geinisman, Y

“…Analysis of axospinous synapses in the rat dentate gyrus, using three-dimensional reconstructions from electron micrographs of serial sections, revealed a…”
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Spatially restricted actin-regulatory signaling contributes to synapse morphology by Nicholson, Daniel A., Cahill, Michael E., Tulisiak, Christopher T., Geinisman, Yuri, Penzes, Peter

“…J. Neurochem. (2012) 121, 852–860. The actin cytoskeleton in dendritic spines is organized into microdomains, but how signaling molecules that regulate actin…”
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Anatomical evidence for convergence of olfactory, gustatory, and visceral afferent pathways in mouse cerebral cortex by Shipley, M T, Geinisman, Y

“…Flavor perception requires the neural integration of olfactory, gustatory and, possibly, visceral afferent information. Presently, it is not known where, or…”
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Synaptic strength and postsynaptically silent synapses through advanced aging in rat hippocampal CA 1 pyramidal neurons by SAMETSKY, Evgeny A, DISTERHOFT, John F, GEINISMAN, Yuri, NICHOLSON, Daniel A

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Synapse Distribution Suggests a Two-Stage Model of Dendritic Integration in CA1 Pyramidal Neurons by Katz, Yael, Menon, Vilas, Nicholson, Daniel A, Geinisman, Yuri, Kath, William L, Spruston, Nelson

“…Competing models have been proposed to explain how neurons integrate the thousands of inputs distributed throughout their dendritic trees. In a simple global…”
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Hippocampal markers of age-related memory dysfunction: Behavioral, electrophysiological and morphological perspectives by Geinisman, Yuri, Detoledo-Morrell, Leyla, Morrell, Frank, Heller, Richard E.

“…This review will (a) summarize the available data regarding functional and structural changes observed in the hippocampal formation during normal aging, (b)…”
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Induction of long-term potentiation is associated with an increase in the number of axospinous synapses with segmented postsynaptic densities by Geinisman, Y, deToledo-Morrell, L, Morrell, F

“…Long-term potentiation (LTP) is characterized by a long-lasting enhancement of synaptic efficacy which may be due to an increase in synaptic numbers. The…”
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Synapse restructuring associated with the maintenance phase of hippocampal long-term potentiation by Geinisman, Yuri, Detoledo-Morrell, Leyla, Morrell, Frank, Persina, Inna S., Beatty, Michael A.

“…Synapses in the middle molecular layer of the rat dentate gyrus were analyzed by electron microscopy during the maintenance phase of long‐term potentiation…”
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Restructuring of Synapses on Hippocampal Dendritic Spines Associated With Hippocampal LTP by Geinisman, Yuri

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