Search Results - "Geiger, Peter G"

Vital ex vivo tissue labeling and pathology-guided micropunching to characterize cellular heterogeneity in the tissue microenvironment by Johnson, Brian P, Vitek, Ross A, Geiger, Peter G, Huang, Wei, Jarrard, David F, Lang, Joshua M, Beebe, David J

“…Cellular heterogeneity within the tissue microenvironment may underlie chemotherapeutic resistance and response, enabling tumor evolution; however, this…”
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A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development by Johnson, Brian P, Vitek, Ross A, Morgan, Molly M, Fink, Dustin M, Beames, Tyler G, Geiger, Peter G, Beebe, David J, Lipinski, Robert J

“…Paracrine signaling in the tissue microenvironment is a central mediator of morphogenesis, and modeling this dynamic intercellular activity is critical to…”
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Utility of micro-ribonucleic acid profile for predicting recurrence of rectal cancer by Riordan, Alexander M., BA, Thomas, Marie K., MD, Ronnekleiv-Kelly, Sean, MD, Warner, Thomas, MD, Geiger, Peter G., BS, Kennedy, Gregory D., MD, PhD

“…Abstract Background In early-stage rectal cancer, the surgeon must decide between the high morbidity of radical surgery and the high recurrence rates of local…”
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The Aryl Hydrocarbon Receptor is a Repressor of Inflammation-associated Colorectal Tumorigenesis in Mouse by Díaz-Díaz, Carol J, Ronnekleiv-Kelly, Sean M, Nukaya, Manabu, Geiger, Peter G, Balbo, Silvia, Dator, Romel, Megna, Bryant W, Carney, Patrick R, Bradfield, Christopher A, Kennedy, Gregory D

“…OBJECTIVE:To determine the role of the aryl hydrocarbon receptor (AHR) in colitis-associated colorectal tumorigenesis. BACKGROUND:Colorectal cancer (CRC) is…”
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Engineering Epithelial-Mesenchymal Microtissues to Study Cell-Cell Interactions in Development by Reynolds, Jacob I, Vitek, Ross A, Geiger, Peter G, Johnson, Brian P

“…Intercellular signaling drives human development, but there is a paucity of in vitro models that recapitulate important tissue architecture while remaining…”
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Fresh tissue procurement and preparation for multicompartment and multimodal analysis of the prostate tumor microenvironment by Vitek, Ross A., Huang, Wei, Geiger, Peter G., Heninger, Erika, Lang, Joshua M., Jarrard, David F., Beebe, David J., Johnson, Brian P.

“…Background Prostatic cancers include a diverse microenvironment of tumor cells, cancer‐associated fibroblasts, and immune components. This tumor…”
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Aryl hydrocarbon receptor-dependent apoptotic cell death induced by the flavonoid chrysin in human colorectal cancer cells by Ronnekleiv-Kelly, Sean M, Nukaya, Manabu, Díaz-Díaz, Carol J, Megna, Bryant W, Carney, Patrick R, Geiger, Peter G, Kennedy, Gregory D

“…Highlights • The treatment of flavonoid chrysin showed a chemopreventive effect in human colorectal cancer cells via the apoptosis pathway. • Up-regulation and…”
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Enzymatic Reducibility in Relation to Cytotoxicity for Various Cholesterol Hydroperoxides by Korytowski, Witold, Geiger, Peter G, Girotti, Albert W

“…Phospholipid hydroperoxide glutathione peroxidase (PHGPX) is a selenoenzyme that can catalyze the direct reduction of various membrane lipid hydroperoxides and…”
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Loss of aryl hydrocarbon receptor within colonic epithelium increases susceptibility to colon tumor formation by Ronnekleiv-Kelly, Sean M., MD, Geiger, Peter G., MS, Kennedy, Gregory D., MD, PhD, FACS

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Electron paramagnetic resonance study of peripheral blood mononuclear cells from patients with refractory solid tumors treated with Triapine by Kolesar, Jill M., Schelman, William R., Geiger, Peter G., Holen, Kyle D., Traynor, Anne M., Alberti, Dona B., Thomas, James P., Chitambar, Christopher R., Wilding, George, Antholine, William E.

“…The metal chelator Triapine®, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, is a potent inhibitor of ribonucleotide reductase. EPR spectra consistent…”
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Abstract 4443: PB-42: Design and characterization of a glutathione pro-drug selectively delivered to normal tissue and not tumor tissue by Thomas, James P., Geiger, Peter G.

“…The vast majority of cancer treatment regimens involve cytotoxic chemotherapy or radiation with a narrow therapeutic index. More than ½ of all approved…”
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Lipid Peroxidation in Photodynamically Stressed Mammalian Cells: Use of Cholesterol Hydroperoxides as Mechanistic Reporters by Geiger, Peter G., Korytowski, Witold, Lin, Fubao, Girotti, Albert W.

“…Photodynamic action of merocyanine 540, an antileukemic sensitizing dye, on murine L1210 cells results in the formation of lipid hydroperoxides and loss of…”
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High-performance liquid chromatography with mercury cathode electrochemical detection: application to lipid hydroperoxide analysis by Korytowski, Witold, Geiger, Peter G., Girotti, Albert W.

“…Lipid hydroperoxide species can be analyzed with high sensitivity and specificity, using reversed-phase high-performance liquid chromatography with reductive…”
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Abstract 1175: Differential patterns of immune infiltration in the tumor immune microenvironment associate with therapeutic response in primary prostate cancer following chemohormonal therapy by Heninger, Erika, Sperger, Jamie M., Weinstein, Kristin, Johnson, Brian P., Geiger, Peter G., Wells, Shane, Cho, Steve Y., Huang, Wei, Tsourkas, Philippos, McIlwain, Sean, Ong, Irene M., Kerr, Sheena C., Jarrard, David F., Beebe, David J., Lang, Joshua M.

“…There is a critical need to develop novel therapeutic strategies and diagnostic tools to precisely deliver treatments to improve survival for men with prostate…”
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Protoporphyrin IX-Sensitized Photoinactivation of 5-Aminolevulinate-Treated Leukemia Cells: Effects of Exogenous Iron by Lin, Fubao, Geiger, Peter G., Korytowski, Witold, Girotti, Albert W.

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Selenoperoxidase-mediated cytoprotection against merocyanine 540-sensitized photoperoxidation and photokilling of leukemia cells by FUBAO LIN, GEIGER, P. G, GIROTTI, A. W

“…Photodynamic therapy with the lipophilic sensitizing dye merocyanine 540 (MC540) is a promising new approach for extracorporeal purging of neoplastic cells…”
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The aryl hydrocarbon receptor mediates the chemopreventive effect of indole-3-carbinol in an inflammation-associated colorectal tumorigenesis model by Díaz-Díaz, Carol J., Ronnekleiv-Kelly, Sean M., Nukaya, Manabu, Geiger, Peter G., Hecht, Stephen S., Balbo, Silvia, Megna, Bryant W., Carney, Patrick R., Bradfield, Christopher A., Kennedy, Gregory D.

“…The deficiency of AHR led to an increase in the susceptibility to colitis-associated colorectal tumorigenesis in mice. In contrast, the activation of AHR by…”
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Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins by Thomas, J P, Geiger, P G, Maiorino, M, Ursini, F, Girotti, A W

“…Lipid hydroperoxides (LOOHs) in various lipid assemblies are shown to be efficiently reduced and deactivated by phospholipid hydroperoxide glutathione…”
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Utility of miRNA profile for predicting recurrence of rectal cancer by Riordan, Alexander M, Thomas, Marie K, Ronnekleiv-Kelly, Sean, Warner, Thomas, Geiger, Peter G, Kennedy, Gregory D

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Lipid hydroperoxide analysis by high-performance liquid chromatography with mercury cathode electrochemical detection by Korytowski, W, Geiger, P G, Girotti, A W

“…In addition to the applications described, HPLC-EC(Hg) can be used for determining LOOHs in lipoproteins and for monitoring LOOH detoxification in cells. As it…”
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