Search Results - "Geiger, P G"

Lethal damage to endothelial cells by oxidized low density lipoprotein: role of selenoperoxidases in cytoprotection against lipid hydroperoxide- and iron-mediated reactions by Thomas, JP, Geiger, PG, Girotti, AW

“…Oxidized low density lipoprotein (LDLox) is believed to be an important contributor to endothelial cytodamage and atherogenesis. The purpose of this study was…”
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Selenoperoxidase-mediated cytoprotection against the damaging effects of tert-butyl hydroperoxide on leukemia cells by Geiger, P G, Lin, F, Girotti, A W

“…Murine leukemia L1210 cells grown for 5-7 d in the presence of 1% serum without added selenium [Se(-) cells] expressed < 5% of the glutathione peroxidase (GPX)…”
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Selenoperoxidase-mediated cytoprotection against merocyanine 540-sensitized photoperoxidation and photokilling of leukemia cells by FUBAO LIN, GEIGER, P. G, GIROTTI, A. W

“…Photodynamic therapy with the lipophilic sensitizing dye merocyanine 540 (MC540) is a promising new approach for extracorporeal purging of neoplastic cells…”
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Lethal damage to murine L1210 cells by exogenous lipid hydroperoxides: protective role of glutathione-dependent selenoperoxidases by Geiger, P G, Thomas, J P, Girotti, A W

“…The effect of selenium deprivation on the viability of murine L1210 cells exposed to various exogenous lipid hydroperoxides has been investigated…”
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Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins by Thomas, J P, Geiger, P G, Maiorino, M, Ursini, F, Girotti, A W

“…Lipid hydroperoxides (LOOHs) in various lipid assemblies are shown to be efficiently reduced and deactivated by phospholipid hydroperoxide glutathione…”
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Lipid hydroperoxide analysis by high-performance liquid chromatography with mercury cathode electrochemical detection by Korytowski, W, Geiger, P G, Girotti, A W

“…In addition to the applications described, HPLC-EC(Hg) can be used for determining LOOHs in lipoproteins and for monitoring LOOH detoxification in cells. As it…”
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Lipid Peroxidation in Photodynamically Stressed Mammalian Cells: Use of Cholesterol Hydroperoxides as Mechanistic Reporters by Geiger, Peter G., Korytowski, Witold, Lin, Fubao, Girotti, Albert W.

“…Photodynamic action of merocyanine 540, an antileukemic sensitizing dye, on murine L1210 cells results in the formation of lipid hydroperoxides and loss of…”
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Enzymatic Reducibility in Relation to Cytotoxicity for Various Cholesterol Hydroperoxides by Korytowski, Witold, Geiger, Peter G, Girotti, Albert W

“…Phospholipid hydroperoxide glutathione peroxidase (PHGPX) is a selenoenzyme that can catalyze the direct reduction of various membrane lipid hydroperoxides and…”
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High-performance liquid chromatography with mercury cathode electrochemical detection: application to lipid hydroperoxide analysis by Korytowski, Witold, Geiger, Peter G., Girotti, Albert W.

“…Lipid hydroperoxide species can be analyzed with high sensitivity and specificity, using reversed-phase high-performance liquid chromatography with reductive…”
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Photodynamically generated 3-beta-hydroxy-5 alpha-cholest-6-ene-5- hydroperoxide: toxic reactivity in membranes and susceptibility to enzymatic detoxification by Geiger, P G, Korytowski, W, Girotti, A W

“…Singlet oxygen (1O2)-mediated photooxidation of cholesterol gives three hydroperoxide products: 3 beta-hydroxy-5 alpha-cholest-6-ene-5-hydroperoxide (5…”
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Delayed Hyperresistance of Endothelial Cells to Photodynamic Inactivation After Contact with Hemin by Lin, Fubao, Bertling, Chad J., Geiger, Peter G., Girotti, Albert W.

“…Hemin (ferriprotoporphyrin IX), the oxidized prosthetic group of hemoglobin, is a potential source of prooxidant iron in heavily vascularized tumors. We have…”
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Selenoperoxidase-dependent glutathione cycle activity in peroxide-challenged leukemia cells by Korytowski, Witold, Bachowski, Gary J., G. Geiger, Peter, Lin, Fubao, Zhao, Guochang, Girotti, Albert W.

“…Murine leukemia L1210 cells rendered deficient in glutathione peroxidase (GPX) and phospholipid hydroperoxide glutathione peroxidase (PHGPX) by Se deprivation…”
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Protoporphyrin IX-Sensitized Photoinactivation of 5-Aminolevulinate-Treated Leukemia Cells: Effects of Exogenous Iron by Lin, Fubao, Geiger, Peter G., Korytowski, Witold, Girotti, Albert W.

“…— Photodynamic therapy with 5‐aminolevulinic acid (ALA) is based on metabolism of ALA to a photosensitizing agent, protoporphyrin IX (PpIX), in tumor cells…”
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Protoporphyrin IX-Sensitized Photoinactivation of 5-Aminolevulinate-Treated Leukemia Cells: Effects of Exogenous Iron by Lin, Fubao, Geiger, Peter G., Korytowski, Witold, Girotti, Albert W.

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