Search Results - "Geiger, Jonathan D."

Janus sword actions of chloroquine and hydroxychloroquine against COVID-19 by Chen, Xuesong, Geiger, Jonathan D.

“…Chloroquine (CQ) and its analogue hydroxychloroquine (HCQ) have been thrust into our everyday vernacular because some believe, based on very limited basic and…”
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HIV‐1 Tat endocytosis and retention in endolysosomes affects HIV‐1 Tat‐induced LTR transactivation in astrocytes by Khan, Nabab, Halcrow, Peter W., Afghah, Zahra, Baral, Aparajita, Geiger, Jonathan D., Chen, Xuesong

“…The presence of latent HIV‐1 reservoirs in the periphery and brain represents a major obstacle to curing HIV‐1 infection. As an essential protein for HIV‐1…”
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Role of Endolysosomes in Severe Acute Respiratory Syndrome Coronavirus-2 Infection and Coronavirus Disease 2019 Pathogenesis: Implications for Potential Treatments by Khan, Nabab, Chen, Xuesong, Geiger, Jonathan D

“…Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an enveloped, single-stranded RNA virus. Humans infected with SARS-CoV-2 develop a disease…”
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Role of endolysosomes and inter-organellar signaling in brain disease by Afghah, Zahra, Chen, Xuesong, Geiger, Jonathan D.

“…Endosomes and lysosomes (endolysosomes) are membrane bounded organelles that play a key role in cell survival and cell death. These acidic intracellular…”
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Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis by Khan, Nabab, Geiger, Jonathan D

“…Human immunodeficiency virus (HIV)-1 and HIV-2 originated from cross-species transmission of simian immunodeficiency viruses (SIVs). Most of these transfers…”
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Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities by Geiger, Jonathan D, Khan, Nabab, Murugan, Madhuvika, Boison, Detlev

“…The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical…”
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Involvement of Endolysosomes and Aurora Kinase A in the Regulation of Amyloid β Protein Levels in Neurons by Afghah, Zahra, Khan, Nabab, Datta, Gaurav, Halcrow, Peter W, Geiger, Jonathan D, Chen, Xuesong

“…Aurora kinase A (AURKA) is a serine/threonine-protein kinase that regulates microtubule organization during neuron migration and neurite formation. Decreased…”
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Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum by Chen, Xuesong, Lan, Xun, Roche, Ian, Liu, Rugao, Geiger, Jonathan D

“…The blood-brain barrier (BBB) is important physiologically. Pathologically, BBB disruption has been implicated in a wide spectrum of neurological disorders…”
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Role of Divalent Cations in HIV-1 Replication and Pathogenicity by Khan, Nabab, Chen, Xuesong, Geiger, Jonathan D

“…Divalent cations are essential for life and are fundamentally important coordinators of cellular metabolism, cell growth, host-pathogen interactions, and cell…”
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Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases by Chen, Xuesong, Ghribi, Othman, Geiger, Jonathan D

“…Sporadic Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the most common neurodegenerative diseases and as such they represent major public…”
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Overcoming Chemoresistance: Altering pH of Cellular Compartments by Chloroquine and Hydroxychloroquine by Halcrow, Peter W, Geiger, Jonathan D, Chen, Xuesong

“…Resistance to the anti-cancer effects of chemotherapeutic agents (chemoresistance) is a major issue for people living with cancer and their providers. A…”
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Correction: Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease by Chen, Xuesong, Gawryluk, Jeremy W, Wagener, John F, Ghribi, Othman, Geiger, Jonathan D

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Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet by Bough, Kristopher J., Wetherington, Jonathon, Hassel, Bjørnar, Pare, Jean Francois, Gawryluk, Jeremy W., Greene, James G., Shaw, Renee, Smith, Yoland, Geiger, Jonathan D., Dingledine, Raymond J.

“…Objective The full anticonvulsant effect of the ketogenic diet (KD) can require weeks to develop in rats, suggesting that altered gene expression is involved…”
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HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells by Datta, Gaurav, Miller, Nicole M, Afghah, Zahra, Geiger, Jonathan D, Chen, Xuesong

“…Human immunodeficiency virus type 1 (HIV-1) associated neuropathy is the most common neurological complication of HIV-1, with debilitating pain affecting the…”
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The impact of methodology on the reproducibility and rigor of DNA methylation data by Boison, Detlev, Masino, Susan A., Lubin, Farah D., Guo, Kai, Lusardi, Theresa, Sanchez, Richard, Ruskin, David N., Ohm, Joyce, Geiger, Jonathan D., Hur, Junguk

“…Epigenetic modifications are crucial for normal development and implicated in disease pathogenesis. While epigenetics continues to be a burgeoning research…”
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Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation by Khan, Nabab, Datta, Gaurav, Geiger, Jonathan D, Chen, Xuesong

“…Apolipoprotein E (ApoE) is the major carrier protein that mediates the transport and delivery of cholesterol and other lipids in the brain. Three isoforms of…”
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Role of endolysosomes in HIV-1 Tat-induced neurotoxicity by Hui, Liang, Chen, Xuesong, Haughey, Norman J, Geiger, Jonathan D

“…Combined anti-retroviral therapeutic drugs effectively increase the lifespan of HIV-1-infected individuals who then have a higher prevalence of HAND (HIV-1…”
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GABAB Receptor Activation Inhibits Neuronal Excitability and Spatial Learning in the Entorhinal Cortex by Activating TREK-2 K+ Channels by Deng, Pan-Yue, Xiao, Zhaoyang, Yang, Chuanxiu, Rojanathammanee, Lalida, Grisanti, Laurel, Watt, John, Geiger, Jonathan D., Liu, Rugao, Porter, James E., Lei, Saobo

“…The entorhinal cortex (EC) is regarded as the gateway to the hippocampus and thus is essential for learning and memory. Whereas the EC expresses a high density…”
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Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets? by Masino, Susan A, Geiger, Jonathan D

“…Abnormal neuronal signaling caused by metabolic changes characterizes several neurological disorders, and in some instances metabolic interventions provide…”
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Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease by Chen, Xuesong, Gawryluk, Jeremy W, Wagener, John F, Ghribi, Othman, Geiger, Jonathan D

“…High levels of serum cholesterol and disruptions of the blood brain barrier (BBB) have all been implicated as underlying mechanisms in the pathogenesis of…”
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