Search Results - "Geiger, Jonathan"

HIV‐1 Tat endocytosis and retention in endolysosomes affects HIV‐1 Tat‐induced LTR transactivation in astrocytes by Khan, Nabab, Halcrow, Peter W., Afghah, Zahra, Baral, Aparajita, Geiger, Jonathan D., Chen, Xuesong

“…The presence of latent HIV‐1 reservoirs in the periphery and brain represents a major obstacle to curing HIV‐1 infection. As an essential protein for HIV‐1…”
Get full text

Janus sword actions of chloroquine and hydroxychloroquine against COVID-19 by Chen, Xuesong, Geiger, Jonathan D.

“…Chloroquine (CQ) and its analogue hydroxychloroquine (HCQ) have been thrust into our everyday vernacular because some believe, based on very limited basic and…”
Get full text

Role of Endolysosomes in Severe Acute Respiratory Syndrome Coronavirus-2 Infection and Coronavirus Disease 2019 Pathogenesis: Implications for Potential Treatments by Khan, Nabab, Chen, Xuesong, Geiger, Jonathan D

“…Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an enveloped, single-stranded RNA virus. Humans infected with SARS-CoV-2 develop a disease…”
Get full text

Role of endolysosomes and inter-organellar signaling in brain disease by Afghah, Zahra, Chen, Xuesong, Geiger, Jonathan D.

“…Endosomes and lysosomes (endolysosomes) are membrane bounded organelles that play a key role in cell survival and cell death. These acidic intracellular…”
Get full text

Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis by Khan, Nabab, Geiger, Jonathan D

“…Human immunodeficiency virus (HIV)-1 and HIV-2 originated from cross-species transmission of simian immunodeficiency viruses (SIVs). Most of these transfers…”
Get full text

Involvement of organelles and inter-organellar signaling in the pathogenesis of HIV-1 associated neurocognitive disorder and Alzheimer’s disease by Khan, Nabab, Haughey, Norman J., Nath, Avindra, Geiger, Jonathan D.

“…•Endolysosomes physically and functionally interact with other organelles.•Alterations in endolysosome structure and function are implicated in HAND and AD.•A…”
Get full text

Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production by Chen, Xuesong, Hui, Liang, Geiger, Nicholas H, Haughey, Norman J, Geiger, Jonathan D

“…Abstract The increased life expectancy of people living with HIV-1/AIDS is accompanied by increased prevalence of HIV–1-associated neurocognitive disorder. As…”
Get full text

Role of endolysosome function in iron metabolism and brain carcinogenesis by Halcrow, Peter W., Lynch, Miranda L., Geiger, Jonathan D., Ohm, Joyce E.

“…Iron, the most abundant metal in human brain, is an essential microelement that regulates numerous cellular mechanisms. Some key physiological roles of iron…”
Get full text

Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities by Geiger, Jonathan D, Khan, Nabab, Murugan, Madhuvika, Boison, Detlev

“…The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical…”
Get full text

Involvement of Endolysosomes and Aurora Kinase A in the Regulation of Amyloid β Protein Levels in Neurons by Afghah, Zahra, Khan, Nabab, Datta, Gaurav, Halcrow, Peter W, Geiger, Jonathan D, Chen, Xuesong

“…Aurora kinase A (AURKA) is a serine/threonine-protein kinase that regulates microtubule organization during neuron migration and neurite formation. Decreased…”
Get full text

Heterogeneity of ferrous iron‐containing endolysosomes and effects of endolysosome iron on endolysosome numbers, sizes, and localization patterns by Halcrow, Peter W., Kumar, Nirmal, Afghah, Zahra, Fischer, Jalyn P., Khan, Nabab, Chen, Xuesong, Meucci, Olimpia, Geiger, Jonathan D.

“…Endolysosomes are key regulators of iron metabolism and are central to iron trafficking and redox signaling. Iron homeostasis is linked to endolysosome acidity…”
Get full text

Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum by Chen, Xuesong, Lan, Xun, Roche, Ian, Liu, Rugao, Geiger, Jonathan D

“…The blood-brain barrier (BBB) is important physiologically. Pathologically, BBB disruption has been implicated in a wide spectrum of neurological disorders…”
Get full text

Endolysosome Localization of ERα Is Involved in the Protective Effect of 17α-Estradiol against HIV-1 gp120-Induced Neuronal Injury by Datta, Gaurav, Miller, Nicole M, Du, Wenjuan, Geiger, Jonathan D, Chang, Sulie, Chen, Xuesong

“…Neurotoxic HIV-1 viral proteins contribute to the development of HIV-associated neurocognitive disorder (HAND), the prevalence of which remains high (30-50%)…”
Get full text

Lysosomal Stress Response (LSR): Physiological Importance and Pathological Relevance by Lakpa, Koffi L, Khan, Nabab, Afghah, Zahra, Chen, Xuesong, Geiger, Jonathan D

“…Extensive work has characterized endoplasmic reticulum (ER) and mitochondrial stress responses. In contrast, very little has been published about stress…”
Get full text

Role of Divalent Cations in HIV-1 Replication and Pathogenicity by Khan, Nabab, Chen, Xuesong, Geiger, Jonathan D

“…Divalent cations are essential for life and are fundamentally important coordinators of cellular metabolism, cell growth, host-pathogen interactions, and cell…”
Get full text

HIV-1 gp120-Induced Endolysosome de-Acidification Leads to Efflux of Endolysosome Iron, and Increases in Mitochondrial Iron and Reactive Oxygen Species by Halcrow, Peter W., Lakpa, Koffi L., Khan, Nabab, Afghah, Zahra, Miller, Nicole, Datta, Gaurav, Chen, Xuesong, Geiger, Jonathan D.

“…The HIV-1 coat protein gp120 continues to be implicated in the pathogenesis of HIV-1 associated neurocognitive disorder (HAND); a condition known to affect…”
Get full text

Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases by Chen, Xuesong, Ghribi, Othman, Geiger, Jonathan D

“…Sporadic Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the most common neurodegenerative diseases and as such they represent major public…”
Get more information

Two‐pore channels regulate Tat endolysosome escape and Tat‐mediated HIV‐1 LTR transactivation by Khan, Nabab, Halcrow, Peter W., Lakpa, Koffi L., Afghah, Zahra, Miller, Nicole M., Dowdy, Steven F., Geiger, Jonathan D., Chen, Xuesong

“…HIV‐1 Tat is essential for HIV‐1 replication and appears to play an important role in the pathogenesis of HIV‐associated neurological complications. Secreted…”
Get full text

HERV-K (HML-2) envelope protein induces mitochondrial depolarization and neurotoxicity via endolysosome iron dyshomeostasis by Halcrow, Peter W, Quansah, Darius N K, Kumar, Nirmal, Steiner, Joseph P, Nath, Avindra, Geiger, Jonathan D

“…Human endogenous retroviruses (HERVs) are associated with the pathogenesis of amyotrophic lateral sclerosis (ALS); a disease characterized by motor neuron…”
Get full text

HERV-K (HML-2) Envelope Protein Induces Mitochondrial Depolarization and Neurotoxicity via Endolysosome Iron Dyshomostasis by Halcrow, Peter W, Quansah, Darius NK, Kumar, Nirmal, Steiner, Joseph P, Nath, Avindra, Geiger, Jonathan D

“…Human endogenous retroviruses (HERVs) are associated with the pathogenesis of amyotrophic lateral sclerosis (ALS); a disease characterized by motor neuron…”
Get full text