Investigation of the possible association between nosocomial candiduria and candidaemia

This study aimed to determine whether candiduria is associated with the occurrence of nosocomial candidaemia. In the case-control part of the study, 115 cases (nosocomial candidaemia) and 115 controls (nosocomial bacteraemia) were similar in age, severity of condition and time of hospitalisation. Th...

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Published in:	Clinical microbiology and infection Vol. 12; no. 6; pp. 538 - 543
Main Authors:	Binelli, C.A., Moretti, M.L., Assis, R.S., Sauaia, N., Menezes, P.R., Ribeiro, E., Geiger, D.C.P., Mikami, Y., Miyaji, M., Oliveira, M.S., Barone, A.A., Levin, A.S.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Elsevier Ltd 01-06-2006 Blackwell Publishing Ltd Blackwell
Subjects:	Adolescent Adult Aged Aged, 80 and over Bacteraemia Bacterial diseases Bacterial sepsis Biological and medical sciences Brazil - epidemiology Candida Candida - classification Candida - isolation & purification Candida spp candidaemia Candidiasis - epidemiology Candidiasis - microbiology candidurea Case-Control Studies Child Child, Preschool Cross Infection - epidemiology Cross Infection - microbiology DNA Primers - chemistry Electrophoresis, Gel, Pulsed-Field - methods Female Fungemia - epidemiology Fungemia - microbiology General aspects Human bacterial diseases Human infectious diseases. Experimental studies and models Human mycoses Humans Infectious diseases Male Medical sciences Middle Aged Mycoses Mycotic sepsis nosocomial infection Polymerase Chain Reaction - methods Risk Factors Urinary Tract Infections - epidemiology Urinary Tract Infections - microbiology Brazil Candida spp Bacteraemia candidaemia candidurea nosocomial infection Nosocomial infection Candidiasis Mycosis Bacteremia Fungi Infection Fungemia Candida Bacteriosis Fungi Imperfecti Thallophyta
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Summary:	This study aimed to determine whether candiduria is associated with the occurrence of nosocomial candidaemia. In the case-control part of the study, 115 cases (nosocomial candidaemia) and 115 controls (nosocomial bacteraemia) were similar in age, severity of condition and time of hospitalisation. There was a significant association of candidaemia with candiduria (OR 9.79; 95% CI 2.14–44.76). In the microbiology part of the study, 23 pairs of Candida-positive urine and blood cultures were obtained from 23 patients. In ten (43%) cases, the urine and blood culture isolates belonged to different species, and molecular typing showed a difference in two of the 13 cases yielding the same species from both specimens. Overall, there was a significant association between candiduria and candidaemia, but the Candida isolates from urine and blood were different for 52% of the patients. Thus, the data indicated that the urinary tract was probably not a source for the candidaemia.
Bibliography:	Deceased ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1198-743X 1469-0691
DOI:	10.1111/j.1469-0691.2006.01435.x