Search Results - "Gehua Zhen"

Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis by Chen, Hao, Hu, Bo, Lv, Xiao, Zhu, Shouan, Zhen, Gehua, Wan, Mei, Jain, Amit, Gao, Bo, Chai, Yu, Yang, Mi, Wang, Xiao, Deng, Ruoxian, Wang, Lei, Cao, Yong, Ni, Shuangfei, Liu, Shen, Yuan, Wen, Chen, Huajiang, Dong, Xinzhong, Guan, Yun, Yang, Huilin, Cao, Xu

“…Whether sensory nerve can sense bone density or metabolic activity to control bone homeostasis is unknown. Here we found prostaglandin E2 (PGE2) secreted by…”
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Mechanical stress determines the configuration of TGFβ activation in articular cartilage by Zhen, Gehua, Guo, Qiaoyue, Li, Yusheng, Wu, Chuanlong, Zhu, Shouan, Wang, Ruomei, Guo, X. Edward, Kim, Byoung Choul, Huang, Jessie, Hu, Yizhong, Dan, Yang, Wan, Mei, Ha, Taekjip, An, Steven, Cao, Xu

“…Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered the development of disease-modifying therapy. The functional…”
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Transforming growth factor-β in stem cells and tissue homeostasis by Xu, Xin, Zheng, Liwei, Yuan, Quan, Zhen, Gehua, Crane, Janet L, Zhou, Xuedong, Cao, Xu

“…TGF-β 1-3 are unique multi-functional growth factors that are only expressed in mammals, and mainly secreted and stored as a latent complex in the…”
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Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain by Zhu, Shouan, Zhu, Jianxi, Zhen, Gehua, Hu, Yihe, An, Senbo, Li, Yusheng, Zheng, Qin, Chen, Zhiyong, Yang, Ya, Wan, Mei, Skolasky, Richard Leroy, Cao, Yong, Wu, Tianding, Gao, Bo, Yang, Mi, Gao, Manman, Kuliwaba, Julia, Ni, Shuangfei, Wang, Lei, Wu, Chuanlong, Findlay, David, Eltzschig, Holger K, Ouyang, Hong Wei, Crane, Janet, Zhou, Feng-Quan, Guan, Yun, Dong, Xinzhong, Cao, Xu

“…Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms remain unclear. Here, we investigated an unprecedented role of…”
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Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice by Wang, Xiao, Li, Fengfeng, Xie, Liang, Crane, Janet, Zhen, Gehua, Mishina, Yuji, Deng, Ruoxian, Gao, Bo, Chen, Hao, Liu, Shen, Yang, Ping, Gao, Manman, Tu, Manli, Wang, Yiguo, Wan, Mei, Fan, Cunyi, Cao, Xu

“…Acquired heterotopic ossification (HO) is a painful and debilitating disease characterized by extraskeletal bone formation after injury. The exact pathogenesis…”
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Bone‐targeted delivery of TGF‐β type 1 receptor inhibitor rescues uncoupled bone remodeling in Camurati–Engelmann disease by Qin, Yunhao, Tang, Shibing, Zhen, Gehua, Ding, Qiang, Ding, Sheng, Cao, Xu

“…Camurati–Engelmann disease (CED) is a genetic bone‐modeling disorder mainly caused by mutations in the gene that encodes transforming growth factor‐β1…”
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Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice by Sun, Qi, Zhen, Gehua, Li, Tuo Peter, Guo, Qiaoyue, Li, Yusheng, Su, Weiping, Xue, Peng, Wang, Xiao, Wan, Mei, Guan, Yun, Dong, Xinzhong, Li, Shaohua, Cai, Ming, Cao, Xu

“…Osteoarthritis, a highly prevalent degenerative joint disorder, is characterized by joint pain and disability. Available treatments fail to modify…”
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Glucocorticoids Disrupt Skeletal Angiogenesis Through Transrepression of NF‐κB–Mediated Preosteoclast Pdgfb Transcription in Young Mice by Peng, Yi, Lv, Shan, Li, Yusheng, Zhu, Jianxi, Chen, Shijie, Zhen, Gehua, Cao, Xu, Wu, Song, Crane, Janet L.

“…ABSTRACT In the growing skeleton, angiogenesis is intimately coupled with osteogenesis. Chronic, high doses of glucocorticoids (GCs) are associated with…”
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Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis by Zhu, Jianxi, Zhen, Gehua, An, Senbo, Wang, Xiao, Wan, Mei, Li, Yusheng, Chen, Zhiyong, Guan, Yun, Dong, Xinzhong, Hu, Yihe, Cao, Xu

“…Pain is the most prominent symptom of osteoarthritis (OA) progression. However, the relationship between pain and OA progression remains largely unknown. Here…”
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Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice by Ni, Shuangfei, Ling, Zemin, Wang, Xiao, Cao, Yong, Wu, Tianding, Deng, Ruoxian, Crane, Janet L., Skolasky, Richard, Demehri, Shadpour, Zhen, Gehua, Jain, Amit, Wu, Panfeng, Pan, Dayu, Hu, Bo, Lyu, Xiao, Li, Yusheng, Chen, Hao, Qi, Huabin, Guan, Yun, Dong, Xinzhong, Wan, Mei, Zou, Xuenong, Lu, Hongbin, Hu, Jianzhong, Cao, Xu

“…Spinal pain is a major clinical problem, however, its origins and underlying mechanisms remain unclear. Here we report that in mice, osteoclasts induce sensory…”
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Sialylation of TLR2 initiates osteoclast fusion by Dou, Ce, Zhen, Gehua, Dan, Yang, Wan, Mei, Limjunyawong, Nathachit, Cao, Xu

“…The molecular control of osteoclast formation is still not clearly elucidated. Here, we show that a process of cell recognition mediated by Siglec15-TLR2…”
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RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix by Li, Changjun, Zhen, Gehua, Chai, Yu, Xie, Liang, Crane, Janet L., Farber, Emily, Farber, Charles R., Luo, Xianghang, Gao, Peisong, Cao, Xu, Wan, Mei

“…Mesenchymal stem cells (MSCs) participate in the repair/remodelling of many tissues, where MSCs commit to different lineages dependent on the cues in the local…”
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An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+ mononuclear cells and PDGF-BB secretion by Gehua, Zhen, Yang, Dan, Wang, Ruomei, Dou Ce, Guo Qiaoyue, Zarr, Melissa, Liu, Linda N, Chen, Lieping, Deng Ruoxian, Li, Yusheng, Shao Zengwu, Cao, Xu

“…Osteoporosis (OP) is a common age-related disease characterized by a deterioration of bone mass and structure that predisposes patients to fragility fractures…”
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Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation by Morrell, Andrea E, Brown, Genevieve N, Robinson, Samuel T, Sattler, Rachel L, Baik, Andrew D, Gehua Zhen, Cao, Xu, Bonewald, Lynda F, Jin, Weiyang, Kam, Lance C, Guo, X Edward

“…The vast osteocytic network is believed to orchestrate bone metabolic activity in response to mechanical stimuli through production of sclerostin, RANKL, and…”
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Long-term feasibility and biocompatibility of directly microsurgically implanted intrafascicular electrodes in free roaming rabbits by Zhen, Gehua, Chen, Huanwen, Tsai, Shin-Yi, Zhang, Jian, Chen, Tongyi, Jia, Xiaofeng

“…Novel neural interfaces capable of reliably capturing electrical signals are crucial for the development of prostheses. Longitudinal intrafascicular electrodes…”
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Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis by Tu, Manli, Yang, Mi, Yu, Nanxi, Gehua Zhen, Wan, Mei, Liu, Wenlong, Ji, Baochao, Ma, Hairong, Guo, Qiaoyue, Tong, Peijian, Cao, Li, Luo, Xianghang, Cao, Xu

“…Osteoarthritis (OA) causes the destruction of joints. Its pathogenesis is still under investigation, and there is no effective disease-modifying therapy. Here,…”
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Optimized protocol to reduce variable outcomes for the bilateral common carotid artery occlusion model in mice by Zhen, Gehua, Doré, Sylvain

“…The pre-clinical global ischemia model transient bilateral common carotid artery occlusion addresses the unique cascade of events leading to delayed neuronal…”
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Mechanisms of bone pain: Progress in research from bench to bedside by Zhen, Gehua, Fu, Yuhan, Zhang, Chi, Ford, Neil C, Wu, Xiaojun, Wu, Qichao, Yan, Dong, Chen, Xueming, Cao, Xu, Guan, Yun

“…The field of research on pain originating from various bone diseases is expanding rapidly, with new mechanisms and targets asserting both peripheral and…”
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Early electrophysiologic markers predict functional outcome associated with temperature manipulation after cardiac arrest in rats by Jia, Xiaofeng, Koenig, Matthew A, Nickl, Robert, Zhen, Gehua, Thakor, Nitish V, Geocadin, Romergryko G

“…OBJECTIVE:Therapeutic hypothermia after cardiac arrest improves survival and functional outcomes, whereas hyperthermia is harmful. The optimal method of…”
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The therapeutic effect of adipose-derived lipoaspirate cells in femoral head necrosis by improving angiogenesis by Zhang, Weixin, Zheng, Cheng, Yu, Tiefeng, Zhang, Houjian, Huang, Jiaxin, Chen, Liyue, Tong, Peijian, Zhen, Gehua

“…Femoral head necrosis (FHN), one of the most popular joint diseases in the musculoskeletal system, is usually attributed to local ischemia of the femoral head…”
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