Search Results - "Gehrmann, Ulf"

Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes by Cerboni, Silvia, Jeremiah, Nadia, Gentili, Matteo, Gehrmann, Ulf, Conrad, Cécile, Stolzenberg, Marie-Claude, Picard, Capucine, Neven, Bénédicte, Fischer, Alain, Amigorena, Sébastian, Rieux-Laucat, Frédéric, Manel, Nicolas

“…Activation of the cyclic dinucleotide sensor stimulator of interferon (IFN) genes (STING) is critical for IFN and inflammatory gene expression during innate…”
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Human Lung Conventional Dendritic Cells Orchestrate Lymphoid Neogenesis during Chronic Obstructive Pulmonary Disease by Naessens, Thomas, Morias, Yannick, Hamrud, Eva, Gehrmann, Ulf, Budida, Ramachandramouli, Mattsson, Johan, Baker, Tina, Skogberg, Gabriel, Israelsson, Elisabeth, Thörn, Kristofer, Schuijs, Martijn J., Angermann, Bastian, Melville, Faye, Staples, Karl J., Cunoosamy, Danen M., Lambrecht, Bart N.

“…Emerging evidence supports a crucial role for tertiary lymphoid organs (TLOs) in chronic obstructive pulmonary disease (COPD) progression. However, mechanisms…”
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Secretome screening reveals immunomodulating functions of IFNα-7, PAP and GDF-7 on regulatory T-cells by Ding, Mei, Malhotra, Rajneesh, Ottosson, Tomas, Lundqvist, Magnus, Mebrahtu, Aman, Brengdahl, Johan, Gehrmann, Ulf, Bäck, Elisabeth, Ross-Thriepland, Douglas, Isaksson, Ida, Magnusson, Björn, Sachsenmeier, Kris F., Tegel, Hanna, Hober, Sophia, Uhlén, Mathias, Mayr, Lorenz M., Davies, Rick, Rockberg, Johan, Schiavone, Lovisa Holmberg

“…Regulatory T cells (Tregs) are the key cells regulating peripheral autoreactive T lymphocytes. Tregs exert their function by suppressing effector T cells…”
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A MALT1 inhibitor suppresses human myeloid DC, effector T-cell and B-cell responses and retains Th1/regulatory T-cell homeostasis by Dumont, Celine, Sivars, Ulf, Andreasson, Theresa, Odqvist, Lina, Mattsson, Johan, DeMicco, Amy, Pardali, Katerina, Johansson, Gustav, Yrlid, Linda, Cox, Rhona J, Seeliger, Frank, Larsson, Marie, Gehrmann, Ulf, Davis, Andrew M, Vaarala, Outi

“…The paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) regulates nuclear-factor-kappa-B (NF-[kappa]B) activation downstream…”
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Antigen-loaded exosomes alone induce Th1-type memory through a B cell–dependent mechanism by Qazi, Khaleda Rahman, Gehrmann, Ulf, Domange Jordö, Emilie, Karlsson, Mikael C.I., Gabrielsson, Susanne

“…Exosomes are nanovesicles harboring proteins important for antigen presentation. We compared the potency of differently loaded exosomes, directly loaded with…”
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Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration by Esser, Julia, BS, Gehrmann, Ulf, MS, D'Alexandri, Fabio Luiz, PhD, Hidalgo-Estévez, Alicia M., PhD, Wheelock, Craig E., PhD, Scheynius, Annika, PhD, Gabrielsson, Susanne, PhD, Rådmark, Olof, PhD

“…Background Leukotrienes (LTs) are potent proinflammatory lipid mediators with key roles in the pathogenesis of asthma and inflammation. Recently, nanovesicles…”
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Nanovesicles from Malassezia sympodialis and host exosomes induce cytokine responses--novel mechanisms for host-microbe interactions in atopic eczema by Gehrmann, Ulf, Qazi, Khaleda Rahman, Johansson, Catharina, Hultenby, Kjell, Karlsson, Maria, Lundeberg, Lena, Gabrielsson, Susanne, Scheynius, Annika

“…Intercellular communication can occur via the release of membrane vesicles. Exosomes are nanovesicles released from the endosomal compartment of cells…”
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Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress by Cui, Yue, Gutierrez, Saray, Ariai, Sheller, Öberg, Lisa, Thörn, Kristofer, Gehrmann, Ulf, Cloonan, Suzanne M, Naessens, Thomas, Olsson, Henric

“…Iron is a key element for systemic oxygen delivery and cellular energy metabolism. Thus regulation of systemic and local iron metabolism is key for maintaining…”
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Unmet needs in the management of exacerbations of chronic obstructive pulmonary disease by Waeijen-Smit, Kiki, Houben-Wilke, Sarah, DiGiandomenico, Antonio, Gehrmann, Ulf, Franssen, Frits M. E.

“…Exacerbations of chronic obstructive pulmonary disease (COPD) are episodes of acute worsening of respiratory symptoms that require additional therapy. These…”
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Transcriptional Dynamics of NRF2 Overexpression and KEAP1-NRF2 Inhibitors in Human Cell Line and Primary Lung Cells by Hamblet, Corinne, Björhall, Karin, Busch, Susann, Gehrmann, Ulf, Öberg, Lisa, Kubisch-Dohmen, Rebekka, Haas, Sonja, Aneja, Manish K, Geiger, Johannes, Rudolph, Carsten, Hornberg, Ellinor

“…Oxidative stress in the human lung is caused by both internal (e.g., inflammation) and external stressors (smoking, pollution, and infection) to drive…”
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Early diagnostic BioMARKers in exacerbations of chronic obstructive pulmonary disease: protocol of the exploratory, prospective, longitudinal, single-centre, observational MARKED study by Waeijen-Smit, Kiki, DiGiandomenico, Antonio, Bonnell, Jessica, Ostridge, Kristoffer, Gehrmann, Ulf, Sellman, Bret R, Kenny, Tara, van Kuijk, Sander, Peerlings, Daphne, Spruit, Martijn A, Simons, Sami O, Houben-Wilke, Sarah, Franssen, Frits M E

“…IntroductionAcute exacerbations of chronic obstructive pulmonary disease (AECOPD) play a pivotal role in the burden and progressive course of chronic…”
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Cytokine‐regulated Th17 plasticity in human health and diseases by Cerboni, Silvia, Gehrmann, Ulf, Preite, Silvia, Mitra, Suman

“…Orchestra of cytokines regulates phenotypic and functional plasticity of non‐pathogenic and pathogenic Th17 cells in human health and diseases. Summary Upon…”
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Su1794 TOLERABILITY, SAFETY, AND CLINICAL PHARMACOLOGY OF AZD7798, A DEPLETING ANTIBODY TARGETING CCR9 by Harper, Andrew R., Bouma, Gerben, Lundahl, Anna, Larsson, Julia, Bock, David, Eck, Steven, Duncan, Marnie, Nys, Josquin, Mo, John, Gehrmann, Ulf, Arkhammar, Per, Kiraga, Joanna, Popinska, Agnieszka, Soto, Pablo Forte, Belvisi, Maria G., Fowler, Andrew, Marks, Daniel J.

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Harnessing the exosome-induced immune response for cancer immunotherapy by Gehrmann, Ulf, Näslund, Tanja I, Hiltbrunner, Stefanie, Larssen, Pia, Gabrielsson, Susanne

“…Abstract In recent years exosomes have emerged as potent stimulators of immune responses and as agents for cancer therapy. Exosomes can carry a broad variety…”
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Dendritic cell-derived exosomes need to activate both T and B cells to induce antitumor immunity by Näslund, Tanja I, Gehrmann, Ulf, Qazi, Khaleda R, Karlsson, Mikael C I, Gabrielsson, Susanne

“…Exosomes are secreted membrane nanovesicles of endosomal origin and are considered potential cancer vaccine vectors. Phase I clinical trials have been…”
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Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin by Johansson, Henrik J., Vallhov, Helen, Holm, Tina, Gehrmann, Ulf, Andersson, Anna, Johansson, Catharina, Blom, Hans, Carroni, Marta, Lehtiö, Janne, Scheynius, Annika

“…Malassezia sympodialis is a dominant commensal fungi in the human skin mycobiome but is also associated with common skin disorders including atopic eczema…”
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A Phenotypic Screening Approach Using Human Treg Cells Identified Regulators of Forkhead Box p3 Expression by Ding, Mei, Brengdahl, Johan, Lindqvist, Madelene, Gehrmann, Ulf, Ericson, Elke, von Berg, Stefan, Ripa, Lena, Malhotra, Rajneesh

“…Regulatory T (Treg) cells, expressing the transcription factor forkhead box p3 (FOXP3), are the key cells regulating peripheral autoreactive T lymphocytes by…”
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Synergistic Induction of Adaptive Antitumor Immunity by Codelivery of Antigen with α-Galactosylceramide on Exosomes by GEHRMANN, Ulf, HILTBRUNNER, Stefanie, GEORGOUDAKI, Anna-Maria, KARLSSON, Mikael C, NÄSLUND, Tanja I, GABRIELSSON, Susanne

“…Exosomes and the invariant NKT (iNKT) immune cell ligand α-galactosylceramide (αGC) may offer novel tools for cancer immunotherapy. In this study, we…”
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[11C]Vercirnon - a candidate PET radioligand for the CCR9 chemokine receptor by Högnäsbacka, Antonia, Cortes Gonzalez, Miguel Angel, Cselenyi, Zsolt, Jucaite, Aurelija, Dahl, Kenneth, Johnstrom, Peter, Sousa, Vasco, Bergare, Jonas, Nys, Josquin, Gardiner, Philip, Brülls, Mikael, Gehrmann, Ulf, Ble, Francois-Xavier, Les, Karolina, Elmore, Charles, Mackay, Jamie, Halldin, Christer, Marks, Daniel, Schou, Magnus

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Effects of subtoxic concentrations of TiO2 and ZnO nanoparticles on human lymphocytes, dendritic cells and exosome production by Andersson-Willman, Britta, Gehrmann, Ulf, Cansu, Zekiye, Buerki-Thurnherr, Tina, Krug, Harald F., Gabrielsson, Susanne, Scheynius, Annika

“…Metal oxide nanoparticles are widely used in the paint and coating industry as well as in cosmetics, but the knowledge of their possible interactions with the…”
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