Search Results - "Gehring, Heinz"

Protein arginine methylation: Cellular functions and methods of analysis by Pahlich, Steffen, Zakaryan, Rouzanna P., Gehring, Heinz

“…During the last few years, new members of the growing family of protein arginine methyltransferases (PRMTs) have been identified and the role of arginine…”
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High-throughput tandem-microwell assay identifies inhibitors of the hydrogen sulfide signaling pathway by Zhou, Yueyang, Yu, Jing, Lei, Xiling, Wu, Jianying, Niu, Qi, Zhang, Yixuan, Liu, Hong, Christen, Philipp, Gehring, Heinz, Wu, Fang

“…We report a high-throughput assay for H2S-producing enzymes, which is based on a newly designed tandem-well plate. Screening of 21,599 agents identified…”
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Identification and Characterization of the Nuclear Localization/Retention Signal in the EWS Proto-oncoprotein by Zakaryan, Rouzanna P., Gehring, Heinz

“…Ewing sarcoma (EWS) protein, a member of a large family of RNA-binding proteins, contains an N-terminal transcriptional activation domain (EAD) and a…”
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Inhibitory and structural studies of novel coenzyme-substrate analogs of human histidine decarboxylase by Wu, Fang, Yu, Jing, Gehring, Heinz

“…Histamine, a biogenic amine with important biological functions, is produced from histidine by histidine decarboxylase (HDC), a pyridoxal…”
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Poisoning pyridoxal 5-phosphate-dependent enzymes: a new strategy to target the malaria parasite Plasmodium falciparum by Müller, Ingrid B, Wu, Fang, Bergmann, Bärbel, Knöckel, Julia, Walter, Rolf D, Gehring, Heinz, Wrenger, Carsten

“…The human malaria parasite Plasmodium falciparum is able to synthesize de novo pyridoxal 5-phosphate (PLP), a crucial cofactor, during erythrocytic schizogony…”
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New transition state–based inhibitor for human ornithine decarboxylase inhibits growth of tumor cells by Wu, Fang, Grossenbacher, Doris, Gehring, Heinz

“…Pyridoxal 5′-phosphate (PLP)–dependent ornithine decarboxylase (ODC) is the key enzyme in polyamine synthesis. ODC is overexpressed in many tumor cells and…”
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Structure and mechanism of a cysteine sulfinate desulfinase engineered on the aspartate aminotransferase scaffold by Fernandez, Francisco J., de Vries, Dominique, Peña-Soler, Esther, Coll, Miquel, Christen, Philipp, Gehring, Heinz, Vega, M. Cristina

“…The joint substitution of three active-site residues in Escherichia colil-aspartate aminotransferase increases the ratio of l-cysteine sulfinate desulfinase to…”
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Kinetics of Molecular Chaperone Action by Schmid, Daniel, Baici, Antonio, Gehring, Heinz, Christen, Philipp

“…Molecular chaperones of the Hsp70 type transiently sequester unfolded segments of proteins and promote their correct folding. Target peptides were labeled with…”
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Tyrosine Phosphorylation in the C-Terminal Nuclear Localization and Retention Signal (C-NLS) of the EWS Protein by Gehring, Heinz, Grossenbacher, Doris, Pahlich, Steffen, Leemann-Zakaryan, Ruzanna P.

“…Ewing sarcoma (EWS) proto-oncoprotein, an RNA-binding protein, is involved in DNA recombination and repair, gene expression, RNA processing and transport, as…”
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Different methylation characteristics of protein arginine methyltransferase 1 and 3 toward the Ewing Sarcoma protein and a peptide by Pahlich, Steffen, Bschir, Karim, Chiavi, Claudio, Belyanskaya, Larisa, Gehring, Heinz

“…The multifunctional Ewing Sarcoma (EWS) protein, a member of a large family of RNA‐binding proteins, is extensively asymmetrically dimethylated at arginine…”
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Exposure on Cell Surface and Extensive Arginine Methylation of Ewing Sarcoma (EWS) Protein by Belyanskaya, Larisa L., Gehrig, Peter M., Gehring, Heinz

“…In contrast to the knowledge regarding the function of chimeric Ewing sarcoma (EWS) fusion proteins that arise from chromosomal translocation, the cellular…”
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Empirical calculation of the relative free energies of peptide binding to the molecular chaperone DnaK by Kasper, Patrik, Christen, Philipp, Gehring, Heinz

“…We describe a methodology to calculate the relative free energies of protein‐peptide complex formation. The interaction energy was decomposed into nonpolar,…”
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Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-phosphate Aminotransferase by Fernandez, Francisco J, Vega, M Cristina, Lehmann, Frank, Sandmeier, Erika, Gehring, Heinz, Christen, Philipp, Wilmanns, Matthias

“…In histidine biosynthesis, histidinol-phosphate aminotransferase catalyzes the transfer of the amino group from glutamate to imidazole acetol-phosphate…”
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Maturation-induced Conformational Changes of HIV-1 Capsid Protein and Identification of Two High Affinity Sites for Cyclophilins in the C-terminal Domain by Endrich, M M, Gehrig, P, Gehring, H

“…Viral incorporation of cyclophilin A (CyPA) during the assembly of human immunodeficiency virus type-1 (HIV-1) is crucial for efficient viral replication. CyPA…”
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A novel approach to inhibit intracellular vitamin B 6 ‐dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase by Wu, Fang, Christen, Philipp, Gehring, Heinz

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Structural requirements for novel coenzyme-substrate derivatives to inhibit intracellular ornithine decarboxylase and cell proliferation by Wu, Fang, Gehring, Heinz

“…Creating transition-state mimics has proven to be a powerful strategy in developing inhibitors to treat malignant diseases in several cases. In the present…”
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Identification of proteins interacting with protein arginine methyltransferase 8: The Ewing sarcoma (EWS) protein binds independent of its methylation state by Pahlich, Steffen, Zakaryan, Rouzanna P., Gehring, Heinz

“…Protein arginine methylation is a eukaryotic posttranslational modification that plays a role in transcription, mRNA splicing and transport, in protein–protein…”
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Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure by Kirsch, J F, Eichele, G, Ford, G C, Vincent, M G, Jansonius, J N, Gehring, H, Christen, P

“…Aspartate aminotransferase is a pyridoxal phosphate-dependent enzyme that catalyses the transamination reaction: L-aspartate + 2-oxoglutarate---oxaloacetate +…”
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A novel approach to inhibit intracellular vitamin B6‐dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase by Wu, Fang, Christen, Philipp, Gehring, Heinz

“…ABSTRACT Pyridoxal‐5'‐phosphate (vitamin B6)‐dependent enzymes play central roles in the metabolism of amino acids. Moreover, the synthesis of polyamines,…”
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Analysis of Ewing Sarcoma (EWS)-Binding Proteins: Interaction with hnRNP M, U, and RNA-Helicases p68/72 within Protein−RNA Complexes by Pahlich, Steffen, Quero, Lilian, Roschitzki, Bernd, Leemann-Zakaryan, Ruzanna P, Gehring, Heinz

“…The human Ewing Sarcoma (EWS) protein belongs to the TET family of RNA-binding proteins and consists of an N-terminal transcriptional activation domain (EAD)…”
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