Search Results - "Gehrig, Stefanie"

Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens by Silby, Mark W, Cerdeño-Tárraga, Ana M, Vernikos, Georgios S, Giddens, Stephen R, Jackson, Robert W, Preston, Gail M, Zhang, Xue-Xian, Moon, Christina D, Gehrig, Stefanie M, Godfrey, Scott A C, Knight, Christopher G, Malone, Jacob G, Robinson, Zena, Spiers, Andrew J, Harris, Simon, Challis, Gregory L, Yaxley, Alice M, Harris, David, Seeger, Kathy, Murphy, Lee, Rutter, Simon, Squares, Rob, Quail, Michael A, Saunders, Elizabeth, Mavromatis, Konstantinos, Brettin, Thomas S, Bentley, Stephen D, Hothersall, Joanne, Stephens, Elton, Thomas, Christopher M, Parkhill, Julian, Levy, Stuart B, Rainey, Paul B, Thomson, Nicholas R

“…Pseudomonas fluorescens are common soil bacteria that can improve plant health through nutrient cycling, pathogen antagonism and induction of plant defenses…”
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Adaptive Divergence in Experimental Populations of Pseudomonas fluorescens. IV. Genetic Constraints Guide Evolutionary Trajectories in a Parallel Adaptive Radiation by McDonald, Michael J, Gehrig, Stefanie M, Meintjes, Peter L, Zhang, Xue-Xian, Rainey, Paul B

“…The capacity for phenotypic evolution is dependent upon complex webs of functional interactions that connect genotype and phenotype. Wrinkly spreader (WS)…”
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Biofilm formation at the air–liquid interface by the Pseudomonas fluorescens SBW25 wrinkly spreader requires an acetylated form of cellulose by Spiers, Andrew J., Bohannon, John, Gehrig, Stefanie M., Rainey, Paul B.

“…Summary The wrinkly spreader (WS) genotype of Pseudomonas fluorescens SBW25 colonizes the air–liquid interface of spatially structured microcosms resulting in…”
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Mutational activation of niche-specific genes provides insight into regulatory networks and bacterial function in a complex environment by Giddens, Stephen R, Jackson, Robert W, Moon, Christina D, Jacobs, Michael A, Zhang, Xue-Xian, Gehrig, Stefanie M, Rainey, Paul B

“…The genome of the plant-colonizing bacterium Pseudomonas fluorescens SBW25 harbors a subset of genes that are expressed specifically on plant surfaces. The…”
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Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases by Schmidt, Moritz J., Gupta, Ashish, Bednarski, Christien, Gehrig-Giannini, Stefanie, Richter, Florian, Pitzler, Christian, Gamalinda, Michael, Galonska, Christina, Takeuchi, Ryo, Wang, Kui, Reiss, Caroline, Dehne, Kerstin, Lukason, Michael J., Noma, Akiko, Park-Windhol, Cindy, Allocca, Mariacarmela, Kantardzhieva, Albena, Sane, Shailendra, Kosakowska, Karolina, Cafferty, Brian, Tebbe, Jan, Spencer, Sarah J., Munzer, Scott, Cheng, Christopher J., Scaria, Abraham, Scharenberg, Andrew M., Cohnen, André, Coco, Wayne M.

“…Streptococcus pyogenes (Spy) Cas9 has potential as a component of gene therapeutics for incurable diseases. One of its limitations is its large size, which…”
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Adaptive Divergence in Experimental Populations of Pseudomonas fluorescens. II. Role of the GGDEF Regulator WspR in Evolution and Development of the Wrinkly Spreader Phenotype by Goymer, Patrick, Kahn, Sophie G, Malone, Jacob G, Gehrig, Stefanie M, Spiers, Andrew J, Rainey, Paul B

“…Wrinkly spreader (WS) genotypes evolve repeatedly in model Pseudomonas populations undergoing adaptive radiation. Previous work identified genes contributing…”
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Addendum to: Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases by Schmidt, Moritz J., Gupta, Ashish, Bednarski, Christien, Gehrig-Giannini, Stefanie, Richter, Florian, Pitzler, Christian, Gamalinda, Michael, Galonska, Christina, Takeuchi, Ryo, Wang, Kui, Reiss, Caroline, Dehne, Kerstin, Lukason, Michael J., Noma, Akiko, Park-Windhol, Cindy, Allocca, Mariacarmela, Kantardzhieva, Albena, Sane, Shailendra, Kosakowska, Karolina, Cafferty, Brian, Tebbe, Jan, Spencer, Sarah J., Munzer, Scott, Cheng, Christopher J., Scaria, Abraham, Scharenberg, Andrew M., Cohnen, André, Coco, Wayne M.

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Role of the Cytoplasmic C Terminus of the FliF Motor Protein in Flagellar Assembly and Rotation by Grünenfelder, Björn, Gehrig, Stefanie, Jenal, Urs

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of the Protease and the Turnover Signal Responsible for Cell Cycle-Dependent Degradation of the Caulobacter FliF Motor Protein by GRÜNENFELDER, Björn, TAWFILIS, Sherif, GEHRIG, Stefanie, ØSTERAS, Magne, EGLIN, Daniel, JENAL, Urs

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Spatially Resolved Monitoring of Neutrophil Elastase Activity with Ratiometric Fluorescent Reporters by Gehrig, Stefanie, Mall, Marcus A., Schultz, Carsten

“…Finding NEmo: In a mouse model for lung inflammation, the lipidated peptide‐based ratiometric fluorescent reporter NEmo‐2 indicates that neutrophil elastase…”
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The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase by Vicuña, Lucas, Strochlic, David E, Latremoliere, Alban, Bali, Kiran Kumar, Simonetti, Manuela, Husainie, Dewi, Prokosch, Sandra, Riva, Priscilla, Griffin, Robert S, Njoo, Christian, Gehrig, Stefanie, Mall, Marcus A, Arnold, Bernd, Devor, Marshall, Woolf, Clifford J, Liberles, Stephen D, Costigan, Michael, Kuner, Rohini

“…Inhibition of T cell–derived leukocyte elastase by neuronal SerpinA3N or the drug Sivelestat reduces neuropathic pain. Neuropathic pain is a major, intractable…”
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Lack of Neutrophil Elastase Reduces Inflammation, Mucus Hypersecretion, and Emphysema, but Not Mucus Obstruction, in Mice with Cystic Fibrosis-like Lung Disease by GEHRIG, Stefanie, DUERR, Julia, MALL, Marcus A, WEITNAUER, Michael, WAGNER, Claudius J, GRAEBER, Simon Y, SCHATTEMY, Jolanthe, HIRTZ, Stephanie, BELAAOUAJ, Abderrazzaq, DALPKE, Alexander H, SCHULTZ, Carsten

“…Recent evidence from clinical studies suggests that neutrophil elastase (NE) released in neutrophilic airway inflammation is a key risk factor for the onset…”
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Neutrophil Adhesion Is a Prerequisite for Antibody-Mediated Proteolytic Tissue Damage in Experimental Models of Epidermolysis Bullosa Acquisita by Yu, Xinhua, Akbarzadeh, Reza, Pieper, Mario, Scholzen, Thomas, Gehrig, Stefanie, Schultz, Carsten, Zillikens, Detlef, König, Peter, Petersen, Frank

“…Although uncontrolled proteolytic activity mediated by activated neutrophils is a major reason for tissue damage, therapeutic approaches using protease…”
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Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis by Dittrich, A Susanne, Kühbandner, Iris, Gehrig, Stefanie, Rickert-Zacharias, Verena, Twigg, Matthew, Wege, Sabine, Taggart, Clifford C, Herth, Felix, Schultz, Carsten, Mall, Marcus A

“…Neutrophil elastase (NE) is a key risk factor for severity of cystic fibrosis (CF) lung disease. Recent studies identified increased NE activity on the surface…”
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Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia by Grimm, Fiona, Asuaje, Agustín, Jain, Aakriti, Silva dos Santos, Mariana, Kleinjung, Jens, Nunes, Patrícia M, Gehrig, Stefanie, Fets, Louise, Darici, Salihanur, MacRae, James I, Anastasiou, Dimitrios

“…Adaptation to chronic hypoxia occurs through changes in protein expression, which are controlled by hypoxia-inducible factor 1α (HIF1α) and are necessary for…”
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Development of drug resistance in Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Treatment of human African trypanosomiasis with natural products (Review) by Gehrig, Stefanie, Efferth, Thomas

“…Human African trypanosomiasis is an infectious disease which has resulted in the deaths of thousands of people in Sub-Saharan Africa. Two subspecies of the…”
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An engineered photoswitchable mammalian pyruvate kinase by Gehrig, Stefanie, Macpherson, Jamie A., Driscoll, Paul C., Symon, Alastair, Martin, Stephen R., MacRae, James I., Kleinjung, Jens, Fraternali, Franca, Anastasiou, Dimitrios

“…Changes in allosteric regulation of glycolytic enzymes have been linked to metabolic reprogramming involved in cancer. Remarkably, allosteric mechanisms…”
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Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity by Gehrig, Stefanie, Eberle, Mariel-Esther, Botschen, Flavia, Rimbach, Katharina, Eberle, Florian, Eigenbrod, Tatjana, Kaiser, Steffen, Holmes, Walter M, Erdmann, Volker A, Sprinzl, Mathias, Bec, Guillaume, Keith, Gérard, Dalpke, Alexander H, Helm, Mark

“…Naturally occurring nucleotide modifications within RNA have been proposed to be structural determinants for innate immune recognition. We tested this…”
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FRET-based and other fluorescent proteinase probes by Hu, Hai-Yu, Gehrig, Stefanie, Reither, Gregor, Subramanian, Devaraj, Mall, Marcus A., Plettenburg, Oliver, Schultz, Carsten

“…The continuous detection of enzyme activities and their application in medical diagnostics is one of the challenges in the translational sciences. Proteinases…”
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Development of Drug Resistance in Trichomonas vaginalis and its Overcoming with Natural Products by Gehrig, Stefanie, Efferth, Thomas

“…Trichomoniasis is an infectious disease afflicting women worldwide. The protozoan parasite Trichomonas vaginalis is the causative agent of this…”
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