Comparative evaluation of in vitro parameters of tamoxifen citrate loaded poly(lactide-co-glycolide), poly(epsilon-caprolactone) and chitosan nanoparticles

Comparative evaluation of in vitro parameters of tamoxifen citrate loaded poly(lactide-co-glycolide), poly(epsilon-caprolactone) and chitosan nanoparticles

Tamoxifen (TAM), the clinical choice for the antiestrogen treatment of advanced or metastatic breast cancer, was formulated in nanoparticulate carrier systems in the form of poly(lactide-co-glycolide) (PLGA), poly-epsilon-caprolactone (PCL) and chitosan (CS) nanoparticles. The PLGA and PCL nanoparti...

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Bibliographic Details
Published in:Pharmazie Vol. 65; no. 12; p. 867
Main Authors: Cirpanli, Y, Yerlikaya, F, Ozturk, K, Erdogar, N, Launay, M, Gegu, C, Leturgez, T, Bilensoy, E, Calis, S, Capan, Y
Format: Journal Article
Language:English
Published: Germany 01-12-2010
Subjects:
Biological Availability
Chitosan
Chromatography, High Pressure Liquid
Drug Compounding
Drug Delivery Systems
Electrochemistry
Estrogen Antagonists - administration & dosage
Estrogen Antagonists - chemistry
Excipients
Lactic Acid
Microscopy, Electron, Scanning
Nanoparticles
Particle Size
Polyesters
Polyglycolic Acid
Tamoxifen - administration & dosage
Tamoxifen - chemistry
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Summary:Tamoxifen (TAM), the clinical choice for the antiestrogen treatment of advanced or metastatic breast cancer, was formulated in nanoparticulate carrier systems in the form of poly(lactide-co-glycolide) (PLGA), poly-epsilon-caprolactone (PCL) and chitosan (CS) nanoparticles. The PLGA and PCL nanoparticles were prepared by a nanoprecipitation technique whereas the CS nanoparticles were prepared by the ionic gelation method. Mean particle sizes were under 260 nm for PLGA and PCL nanoparticles and around 400 nm for CS nanoparticles. Polydispersity indices were less than 0.4 for all formulations. Zeta potential values were positive for TAM loaded nanoparticles because of the positive charge of the drug. Drug loading values were significantly higher for PCL nanoparticles when compared to PLGA and CS nanoparticles. All nanoparticle formulations exhibited controlled release properties. These results indicate that TAM loaded PLGA, PCL and CS nanoparticles may provide promising carrier systems for tumor targeting.
ISSN:0031-7144
DOI:10.1691/ph.2010.0167