Search Results - "Geginat, J."

Central memory and effector memory T cell subsets: function, generation, and maintenance by Sallusto, Federica, Geginat, Jens, Lanzavecchia, Antonio

“…The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent…”
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IL-10 producing regulatory and helper T-cells in systemic lupus erythematosus by Geginat, J., Vasco, M., Gerosa, M., Tas, S.W., Pagani, M., Grassi, F., Flavell, R.A., Meroni, Pl, Abrignani, S.

“…•IL-10 has a dual role in immune responses.•IL-10 is increased in lupus, promotes autoantibody production and is evaluated as a therapeutic target in SLE…”
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The CD4-centered universe of human T cell subsets by Geginat, J, Paroni, M, Facciotti, F, Gruarin, P, Kastirr, I, Caprioli, F, Pagani, M, Abrignani., S

“…Highlights • Continuous exposure to pathogens generates complex human T cell pools. • T cell subsets are classified by cytokine production and tissue…”
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Evidence for a pathogenic role of extrafollicular, IL-10–producing CCR6⁺B helper T cells in systemic lupus erythematosus by Facciotti, F., Larghi, P., Bosotti, R., Vasco, C., Gagliani, N., Cordiglierif, C., Mazzarag, S., Ranzani, V., Rottoli, E., Curti, S., Penatti, A., Karnani, B., Kobayashi, Y., Crosti, M., Bombaci, M., van Hamburg, J. P., Rossetti, G., Gualtierotti, R., Gerosa, M., Gatti, S., Torretta, S., Pignataro, L., Tas, S. W., Abrignani, S., Pagani, M., Grassi, F., Meroni, P. L., Flavell, R. A., Geginat, J.

“…Interleukin 10 (IL-10) is an antiinflammatory cytokine, but also promotes B cell responses and plays a pathogenic role in systemic lupus erythematosus (SLE)…”
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Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells by Ripamonti, A., Provasi, E., Lorenzo, M., De Simone, M., Ranzani, V., Vangelisti, S., Curti, S., Bonnal, R. J. P., Pignataro, L., Torretta, S., Geginat, J., Rossetti, G., Pagani, M., Abrignani, S.

“…Follicular helper T cells (TFHs) are a key component of adaptive immune responses as they help antibody production by B cells. Differentiation and function of…”
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Functional subsets of memory T cells identified by CCR7 expression by Sallusto, F, Langenkamp, A, Geginat, J, Lanzavecchia, A

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P.06.8 T HELPER 2 CELLS ARE NOT INCREASED, WHEREAS NATURAL KILLER T CELLS ARE REDUCED IN THE INFLAMED MUCOSA OF ULCERATIVE COLITIS PATIENTS by Biancheri, P, Facciotti, F, Di Sabatino, A, Caprioli, F, Ammoscato, F, Giuffrida, P, Geginat, J, Corazza, G.R, Macdonald, T.T

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P.02.11 PHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF INFLAMMATORY CELL INFILTRATE IN ADULT-ONSET AUTOIMMUNE ENTEROPATHY AND ITS EVOLUTION WITH GLUCOCORTICOIDS by Paroni, M, Magarotto, A, Orlando, S, Nizzoli, G, Gianelli, U, Ciafardini, C, Conte, D, Abrignani, S, Geginat, J, Caprioli, F

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P.05.9 PHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF INTRAEPITHELIAL AND LAMINA PROPRIA INFLAMMATORY CELL INFILTRATE IN AUTOIMMUNE ENTEROPATHY by Paroni, M, Nizzoli, G, Magarotto, A, Gianelli, U, Ciafardini, C, Conte, D, Abrignani, S, Geginat, J, Caprioli, F

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Cytokine-driven proliferation and differentiation of human naïve, central memory and effector memory CD4 + T cells by Geginat, J, Sallusto, F, Lanzavecchia, A

“…Memory T lymphocytes divide in vivo in the absence of antigen maintaining a pool of central memory (T CM) and effector memory cells (T EM) with distinct…”
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Guidelines for the use of flow cytometry and cell sorting in immunological studies by Akdis, Mübeccel, Bacher, Petra, Battistini, Luca, Bauer, Wolfgang M., Becher, Burkhard, Beisker, Wolfgang, Berek, Claudia, Borsellino, Giovanna, Brinkman, Ryan R., Büscher, Martin, Chow, Sue, Clerici, Mario, Cosmi, Lorenzo, Davies, Derek, Biasi, Sara, Del Zotto, Genny, Della Bella, Silvia, Dessing, Mark, Dieli, Francesco, Ehrhardt, Götz R. A., Engel, Pablo, Engelhardt, Britta, Esser, Charlotte, Fehniger, Todd A., Fillatreau, Simon, Follo, Marie, Foster, John, Frenette, Paul S., García‐Godoy, Maria Dolores, Geginat, Jens, Grogan, Jane, Grummitt, Daryl, Hauser, Anja E., Hiepe, Falk, Holland, Tristan, Hombrink, Pleun, Iannone, Anna, Jonjic, Stipan, Juelke, Kerstin, Jung, Steffen, Kaiser, Toralf, Kurts, Christian, Lannigan, Joanne, Liu, Yanling, Lohoff, Michael, Lombardi, Giovanna, Lovett‐Racke, Amy, Ludewig, Burkhard, Lugli, Enrico, McGrath, Mairi, McInnes, Iain, Mei, Henrik E., Mirrer, David, Mjösberg, Jenny, Müller, Susann, Münz, Christian, Nakayama, Toshinori, O'Connor, José‐Enrique, Oxenius, Annette, Pickl, Winfried, Pinti, Marcello, Pucillo, Carlo, Quataert, Sally A., Radstake, Timothy R. D. J., Rebhahn, Jonathan A., Rico, Laura G., Robinson, J. Paul, Rubartelli, Anna, Ruland, Jürgen, Sanderson, Sharon, Sawitzki, Birgit, Schildberg, Frank, Schimisky, Esther, Schmid, Stephan A, Schmitt, Steffen, Schober, Kilian, Schüler, Thomas, Schumacher, Ton, Scotta, Cristiano, Shemer, Anat, Simon, Anna‐Katharina, Stehle, Christina, Stockinger, Hannes, Tarnok, Attila, Tian, ZhiGang, Tornack, Julia, Trotter, Joe, Voehringer, David, Volk, Hans‐Dieter, Walker, Rachael, Warnatz, Klaus, Warth, Sarah, Wegener, Leonie, Wiedemann, Annika, Willimsky, Gerald, Wurst, Peter, Yu, Liping, Yue, Alice, Zhao, Yi, Ziegler, Susanne

“…The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid…”
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Anchorage Dependence of Mitogen-Induced G1 to S Transition in Primary T Lymphocytes by Geginat, J, Bossi, G, Bender, J. R, Pardi, R

“…Anchorage dependence defines the cellular requirement for integrin-mediated adhesion to substrate to initiate DNA replication in response to growth factors. In…”
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Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines by Geginat, Jens, Lanzavecchia, Antonio, Sallusto, Federica

“…Four human CD8+ T-cell subsets, naive (CCR7+CD45RA+), central memory (TCM, CCR7+CD45RA–), effector memory (TEM, CCR7–CD45RA–), and CD45RA+ effector memory…”
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Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells by Geginat, J, Sallusto, F, Lanzavecchia, A

“…Memory T lymphocytes proliferate in vivo in the absence of antigen maintaining a pool of central memory T cells (T(CM)) and effector memory T cells (T(EM))…”
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Molecular and functional heterogeneity of IL-10-producing CD4+ T cells by Brockmann, Leonie, Soukou, Shiwa, Steglich, Babett, Czarnewski, Paulo, Zhao, Lilan, Wende, Sandra, Bedke, Tanja, Ergen, Can, Manthey, Carolin, Agalioti, Theodora, Geffken, Maria, Seiz, Oliver, Parigi, Sara M., Sorini, Chiara, Geginat, Jens, Fujio, Keishi, Jacobs, Thomas, Roesch, Thomas, Izbicki, Jacob R., Lohse, Ansgar W., Flavell, Richard A., Krebs, Christian, Gustafsson, Jan-Ake, Antonson, Per, Roncarolo, Maria Grazia, Villablanca, Eduardo J., Gagliani, Nicola, Huber, Samuel

“…IL-10 is a prototypical anti-inflammatory cytokine, which is fundamental to the maintenance of immune homeostasis, especially in the intestine. There is an…”
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The induction and function of the anti-inflammatory fate of TH17 cells by Xu, Hao, Agalioti, Theodora, Zhao, Jun, Steglich, Babett, Wahib, Ramez, Vesely, Maria Carolina Amezcua, Bielecki, Piotr, Bailis, Will, Jackson, Ruaidhri, Perez, Daniel, Izbicki, Jakob, Licona-Limón, Paula, Kaartinen, Vesa, Geginat, Jens, Esplugues, Enric, Tolosa, Eva, Huber, Samuel, Flavell, Richard A., Gagliani, Nicola

“…T H 17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the…”
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P706 A distinct subset of tissue-resident Th17 cells expands in the inflamed intestines of Crohn’s Disease patients and responds to colitogenic bacteria by Paroni, M, Leccese, G, Ranzani, V, Pagani, M, Landini, P, Vecchi, M, Abrignani, S, Facciotti, F, Caprioli, F, Geginat, J

“…Abstract Background Inflammatory bowel diseases (IBDs) are characterized by excessive inflammatory T-cell responses to intestinal microbes. Th17-derived Th1…”
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T cell fitness determined by signal strength by Lanzavecchia, Antonio, Geginat, Jens, Gett, Amanda V, Sallusto, Federica

“…Two potential outcomes confront proliferating antigen-stimulated naive T cells: differentiation to effector and memory cells, or deletion. How stimulation…”
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Chemokine receptor expression identifies Pre-T helper (Th)1, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cells by Rivino, Laura, Messi, Mara, Jarrossay, David, Lanzavecchia, Antonio, Sallusto, Federica, Geginat, Jens

“…We previously reported that central-memory T cells (T(CM) cells), which express lymph node homing receptors CCR7 and CD62L, are largely devoid of effector…”
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Toll‐like receptor‐dependent activation of several human blood cell types by protamine‐condensed mRNA by Scheel, Birgit, Teufel, Regina, Probst, Jochen, Carralot, Jean‐Philippe, Geginat, Jens, Radsak, Markus, Jarrossay, David, Wagner, Hermann, Jung, Günther, Rammensee, Hans‐Georg, Hoerr, Ingmar, Pascolo, Steve

“…We reported that RNA condensed on protamine is protected from RNase‐mediated degradation and can be used for vaccination. Here, we show that such complexes are…”
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