Search Results - "Gegg, Colin V"

Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3 by Murray, Justin K., Qian, Yi-Xin, Liu, Benxian, Elliott, Robin, Aral, Jennifer, Park, Cynthia, Zhang, Xuxia, Stenkilsson, Michael, Salyers, Kevin, Rose, Mark, Li, Hongyan, Yu, Steven, Andrews, Kristin L., Colombero, Anne, Werner, Jonathan, Gaida, Kevin, Sickmier, E. Allen, Miu, Peter, Itano, Andrea, McGivern, Joseph, Gegg, Colin V., Sullivan, John K., Miranda, Les P.

“…To realize the medicinal potential of peptide toxins, naturally occurring disulfide-rich peptides, as ion channel antagonists, more efficient pharmaceutical…”
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Discovery of the Migraine Prevention Therapeutic Aimovig (Erenumab), the First FDA-Approved Antibody against a G‑Protein-Coupled Receptor by King, Chadwick Terence, Gegg, Colin V, Hu, Sylvia Nai-Yu, Sen Lu, Hsieng, Chan, Brian M, Berry, Kelly A, Brankow, David W, Boone, Tom J, Kezunovic, Nebojsa, Kelley, Matt R, Shi, Licheng, Xu, Cen

“…In 2018, the United States Food and Drug Administration (FDA) approved Aimovig (erenumab) for the prevention of migraine. Erenumab is the first FDA approved…”
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Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity by Miranda, Les P, Winters, Katherine A, Gegg, Colin V, Patel, Ankita, Aral, Jennifer, Long, Jason, Zhang, Jingwen, Diamond, Stephanie, Guido, Mark, Stanislaus, Shanaka, Ma, Mark, Li, Hongyan, Rose, Mark J, Poppe, Leszek, Véniant, Murielle M

“…A series of conformationally constrained derivatives of glucagon-like peptide-1 (GLP-1) were designed and evaluated. By use of [Gly8]GLP-1(7–37)-NH2 (2)…”
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Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics by Miranda, Les P., Shi, Licheng, Holder, Jerry R., Wright, Marie, Gegg, Colin V., Johnson, Eileen, Wild, Kenneth, Stenkilsson, Michael, Doellgast, George, Manning, Barton H., Salyers, Kevin

“…ABSTRACT Antagonism of the calcitonin gene‐related peptide (CGRP) receptor may be a useful approach for migraine treatment. Selective PEGylated peptide…”
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Identification of Potent, Selective, and Metabolically Stable Peptide Antagonists to the Calcitonin Gene-Related Peptide (CGRP) Receptor by Miranda, Les P, Holder, Jerry Ryan, Shi, Licheng, Bennett, Brian, Aral, Jennifer, Gegg, Colin V, Wright, Marie, Walker, Kenneth, Doellgast, George, Rogers, Rick, Li, Hongyan, Valladares, Violeta, Salyers, Kevin, Johnson, Eileen, Wild, Kenneth

“…Calcitonin gene-related peptide (CGRP) is a 37-residue neuropeptide that can be converted to a CGRP1 receptor antagonist by the truncation of its first seven…”
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Interactions between PEG and type I soluble tumor necrosis factor receptor: Modulation by pH and by PEGylation at the N terminus by Kerwin, Bruce A., Chang, Byeong S., Gegg, Colin V., Gonnelli, Margherita, Li, Tiansheng, Strambini, Giovanni B.

“…The effects of polyethylene glycol (PEG) on protein structure and the molecular details that regulate its association to polypeptides are largely unknown…”
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Characterization of the adenine binding sites of two Dolichos biflorus lectins by Gegg, Colin V, Roberts, David D, Segel, Irwin H, Etzler, Marilynn E

“…The seed lectin and a stem and leaf lectin (DB58) from Dolichos biflorus have high-affinity hydrophobic sites that bind to adenine. The present study employs a…”
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Probing minimal independent folding units in dihydrofolate reductase by molecular dissection by Gegg, Colin V., Bowers, Katherine E., Matthews, C. Robert

“…Molecular dissection was employed to identify minimal independent folding units in dihydrofolate reductase (DHFR) from Escherichia coli. Eight overlapping…”
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Molecular modelling of the Dolichos biflorus seed lectin and its specific interactions with carbohydrates: alpha-D-N-acetyl-galactosamine, Forssman disaccharide and blood group A trisaccharide by Imberty, A, Casset, F, Gegg, C V, Etzler, M E, Pérez, S

“…The three-dimensional structure of Dolichos biflorus seed lectin has been constructed using five legume lectins for which high resolution crystal structures…”
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Photoaffinity labeling of the adenine binding sites of two Dolichos biflorus lectins by Gegg, C.V, Etzler, M.E

“…Two differentially expressed lectins from the legume Dolichos biflorus, the seed lectin and a stem and leaf lectin (DB58), were photoaffinity-labeled at their…”
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Directional coupling of synthetic peptides to poly-L-lysine and applications to the ELISA by Gegg, C V, Etzler, M E

“…Synthetic peptides are increasingly being used as antigens to generate highly specific antisera. Screening the antipeptide sera by enzyme-linked immunosorbent…”
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Molecular modelling of theDolichos biflorus seed lectin and its specific interactions with carbohydrates: ?-D-N-acetyl-galactosamine, Forssman disaccharide and blood group A trisaccharide by Imberty, Anne, Casset, Florence, Gegg, Colin V., Etzler, Marilynn E., P rez, Serge

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Biosynthesis of DB58 lectin in cell suspension cultures of Dolichos biflorus by Schnell, D J, Hori, K, Herrmann, S M, Gegg, C V, Etzler, M E

“…The stem and leaf lectin of the legume, Dolichos biflorus, was found to be expressed in cell suspension cultures derived from calli from this plant. The lectin…”
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The inhibition of ribulose 1,5-bisphosphate carboxylase oxygenase by several 2-carboxyhexitol 1- and 6-phosphates by MCFADDEN, B. A, GEGG, C. V, EL-GUL, T

“…The condensation of D-fructose 6-phosphate or 1-phosphate with cyanide has been used to synthesize 2-carboxyhexitol 6-phosphates and 1-phosphates. The products…”
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