Search Results - "Geertsma, Haley M."

Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation by Geertsma, Haley M, Suk, Terry R, Ricke, Konrad M, Horsthuis, Kyra, Parmasad, Jean-Louis A, Fisk, Zoe A, Callaghan, Steve M, Rousseaux, Maxime W C

“…A growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays a role in the pathogenesis of Parkinson's disease (PD). However, this question…”
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Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy by Parmasad, Jean-Louis A., Ricke, Konrad M., Nguyen, Benjamin, Stykel, Morgan G., Buchner-Duby, Brodie, Bruce, Amanda, Geertsma, Haley M., Lian, Eric, Lengacher, Nathalie A., Callaghan, Steve M., Joselin, Alvin, Tomlinson, Julianna J., Schlossmacher, Michael G., Stanford, William L., Ma, Jiyan, Brundin, Patrik, Ryan, Scott D., Rousseaux, Maxime W. C.

“…Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal…”
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Convergent systems-based approaches identify a role for OCIAD1 in Alzheimer's disease by Geertsma, Haley M., Rousseaux, Maxime W.C.

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A topographical atlas of α-synuclein dosage and cell type-specific expression in adult mouse brain and peripheral organs by Geertsma, Haley M., Fisk, Zoe A., Sauline, Lillian, Prigent, Alice, Kurgat, Kevin, Callaghan, Steve M., Henderson, Michael X., Rousseaux, Maxime W. C.

“…Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and presents pathologically with Lewy pathology and dopaminergic…”
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Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain by Suk, Terry R., Nguyen, Trina T., Fisk, Zoe A., Mitkovski, Miso, Geertsma, Haley M., Parmasad, Jean-Louis A., Heer, Meghan M., Callaghan, Steve M., Benseler, Fritz, Brose, Nils, Tirard, Marilyn, Rousseaux, Maxime W.C.

“…SUMOylation is an evolutionarily conserved eukaryotic posttranslational protein modification with broad biological relevance. Differentiating between the major…”
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