Search Results - "Geerling, J."

Exendin‐4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration by Wang, Y, Parlevliet, E T, Geerling, J J, Tuin, S J L, Zhang, H, Bieghs, V, Jawad, A H M, Shiri‐Sverdlov, R, Bot, I, Jager, S C A, Havekes, L M, Romijn, J A, Willems van Dijk, K, Rensen, P C N

“…Background and Purpose The aetiology of inflammation in the liver and vessel wall, leading to non‐alcoholic steatohepatitis (NASH) and atherosclerosis,…”
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Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies by Geerling, Janine J., Boon, Mariëtte R., Kooijman, Sander, Parlevliet, Edwin T., Havekes, Louis M., Romijn, Johannes A., Meurs, Illiana M., Rensen, Patrick C.N.

“…Important players in triglyceride (TG) metabolism include the liver (production), white adipose tissue (WAT) (storage), heart and skeletal muscle (combustion…”
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Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice by GEERLING, Janine J, BOON, Mariëtte R, VAN DER ZON, Gerard C, VAN DEN BERG, Sjoerd A. A, VAN DEN HOEK, Anita M, LOMBES, Marc, PRINCEN, Hans M. G, HAVEKES, Louis M, RENSEN, Patrick C. N, GUIGAS, Bruno

“…Metformin is the first-line drug for the treatment of type 2 diabetes. Besides its well-characterized antihyperglycemic properties, metformin also lowers…”
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Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor‐driven transcription of hepatic lipogenic genes in vivo by Nahon, Joya E, Groeneveldt, Christianne, Geerling, Janine J, Eck, Miranda, Hoekstra, Menno

“…Background and Purpose Agonists for the liver X receptor (LXR) are considered promising therapeutic moieties in cholesterol‐driven diseases by promoting…”
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GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE3-Leiden mice by Parlevliet, Edwin T, Wang, Yanan, Geerling, Janine J, Schröder-Van der Elst, Janny P, Picha, Kristen, O'Neil, Karyn, Stojanovic-Susulic, Vedrana, Ort, Tatiana, Havekes, Louis M, Romijn, Johannes A, Pijl, Hanno, Rensen, Patrick C N

“…In addition to improve glucose intolerance, recent studies suggest that glucagon-like peptide-1 (GLP-1) receptor agonism also decreases triglyceride (TG)…”
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Effects of Decreased Occlusal Loading during Growth on the Mandibular Bone Characteristics by Hichijo, Natsuko, Tanaka, Eiji, Kawai, Nobuhiko, van Ruijven, Leo J, Langenbach, Geerling E J

“…Bone mass and mineralization are largely influenced by loading. The purpose of this study was to evaluate the reaction of the entire mandibular bone in…”
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Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model by Nahon, Joya E., Hoekstra, Menno, Havik, Stefan R., Van Santbrink, Peter J., Dallinga-Thie, Geesje M., Kuivenhoven, Jan-Albert, Geerling, Janine J., Van Eck, Miranda

“…Proteoglycan 4 (Prg4) has a high structural similarity with the established atherosclerosis-modulating proteoglycan versican, but its role in atherogenesis is…”
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Hematopoietic upstream stimulating factor 1 deficiency is associated with increased atherosclerosis susceptibility in LDL receptor knockout mice by Hoekstra, Menno, Ren, Baoyan, Laurila, Pirkka-Pekka, Hildebrand, Reeni B., Soronen, Jarkko, Frodermann, Vanessa, Li, Zhuang, Boon, Mariëtte R., Geerling, Janine J., Rensen, Patrick C. N., Jauhiainen, Matti, Van Eck, Miranda

“…Total body upstream stimulatory factor 1 (USF1) deficiency in mice is associated with brown adipose tissue activation and a marked protection against the…”
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LXR Agonist T0901317′s Hepatic Impact Overrules Its Atheroprotective Action in Macrophages, Driving Early Atherogenesis in Chow-Diet-Fed Male Apolipoprotein E Knockout Mice by Hoekstra, Menno, de Jong, Laura M, van der Geest, Rick, de Leeuw, Lidewij R, Krisnamurthi, Rani, Geerling, Janine J, Van Eck, Miranda

“…Preclinical studies regarding the potential of liver X receptor (LXR) agonists to inhibit macrophage foam cell formation and the development of atherosclerotic…”
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Biomedical students' satisfaction with and engagement in laboratory e‐learning support are related to their self‐regulation by Moelans, C. B., Geerling, J. J., Radersma, R. D., Moons, M. J., Diest, P. J., Schaaf, M. F.

“…Laboratory e‐learning support tools can assist students' learning while preparing for laboratory classes. To successfully work in such virtual experimental…”
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Aldosterone infusion into the 4th ventricle produces sodium appetite with baroreflex attenuation independent of renal or blood pressure changes by Gasparini, S., Melo, M.R., Andrade-Franzé, G.M.F., Geerling, J.C., Menani, J.V., Colombari, E.

“…•Aldosterone into the 4th V activates HSD2 neurons in the NTS to cause sodium intake.•Aldosterone into the 4th V and sodium intake reduces baroreflex…”
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2-Hydroxypropyl-beta-cyclodextrin Treatment Does Not Induce Atherosclerotic Lesion Regression in Western-Type Diet-Fed Apolipoprotein E Knockout Mice by Snip, Olga S.C, Hoekstra, Menno, Zhang, Yiheng, Geerling, Janine J, Van Eck, Miranda

“…2-Hydroxypropyl-beta-cyclodextrin (2HPβCD) is able to bind and solubilize unesterified cholesterol and may therefore be able to reverse the deposition of…”
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1521 Coordination and handover of terminal ill patients at hospital discharge by Geerling, J, Kok, M, Veenhuis, J, Bosscher, L, Reyners, A

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Sodium deprivation and salt intake activate separate neuronal subpopulations in the nucleus of the solitary tract and the parabrachial complex by Geerling, Joel C., Loewy, Arthur D.

“…Salt intake is an established response to sodium deficiency, but the brain circuits that regulate this behavior remain poorly understood. We studied the…”
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Inhibition of the central melanocortin system decreases brown adipose tissue activity[S] by Kooijman, Sander, Boon, Mariëtte R., Parlevliet, Edwin T., Geerling, Janine J., van de Pol, Vera, Romijn, Johannes A., Havekes, Louis M., Meurs, Illiana, Rensen, Patrick C.N.

“…The melanocortin system is an important regulator of energy balance, and melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of…”
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Reciprocal Control of Drinking Behavior by Median Preoptic Neurons in Mice by Abbott, Stephen B G, Machado, Natalia L S, Geerling, Joel C, Saper, Clifford B

“…Stimulation of glutamatergic neurons in the subfornical organ drives drinking behavior, but the brain targets that mediate this response are not known. The…”
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Osteoclast precursors in murine bone marrow express CD27 and are impeded in osteoclast development by CD70 on activated immune cells by Xiao, Yanling, Song, Ji-Ying, de Vries, Teun J., Fatmawati, Christien, Parreira, Diana B., Langenbach, Geerling E. J., Bąbała, Nikolina, Nolte, Martijn A., Everts, Vincent, Borst, Jannie

“…Osteoclasts (OCs) are bone-resorbing cells that are formed from hematopoietic precursors. OCs ordinarily maintain bone homeostasis, but they can also cause…”
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Dissociation of bone resorption and bone formation in adult mice with a non-functional V-ATPase in osteoclasts leads to increased bone strength by Henriksen, Kim, Flores, Carmen, Thomsen, Jesper S, Brüel, Anne-Marie, Thudium, Christian S, Neutzsky-Wulff, Anita V, Langenbach, Geerling E J, Sims, Natalie, Askmyr, Maria, Martin, Thomas J, Everts, Vincent, Karsdal, Morten A, Richter, Johan

“…Osteopetrosis caused by defective acid secretion by the osteoclast, is characterized by defective bone resorption, increased osteoclast numbers, while bone…”
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Stimulatory Effect of Insulin on Glucose Uptake by Muscle Involves the Central Nervous System in Insulin-Sensitive Mice by COOMANS, Claudia P, BIERMASZ, Nienke R, GEERLING, Janine J, GUIGAS, Bruno, RENSEN, Patrick C. N, HAVEKES, Louis M, ROMIJN, Johannes A

“…Insulin inhibits endogenous glucose production (EGP) and stimulates glucose uptake in peripheral tissues. Hypothalamic insulin signaling is required for the…”
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Implications of High-Dosage Bisphosphonate Treatment on Bone Tissue in the Jaw and Knee Joint by Renders, Greetje A. P., Vermeer, Jenny A. F., Leung, Pui-Ming, Reynaert, Freya, Prins, Carla, Langenbach, Geerling E. J., Everts, Vincent

“…Bisphosphonates are bone antiresorptive agents traditionally used on a relatively large scale for treatment of bone metabolic diseases and on a smaller scale…”
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