Search Results - "Geem, Duke"

Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis by Laroui, Hamed, Viennois, Emilie, Xiao, Bo, Canup, Brandon S.B., Geem, Duke, Denning, Timothy L., Merlin, Didier

“…Patients suffering from inflammatory bowel disease (IBD) are currently treated by systemic drugs that can have significant side effects. Thus, it would be…”
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Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage by Medina-Contreras, Oscar, Harusato, Akihito, Nishio, Hikaru, Flannigan, Kyle L, Ngo, Vu, Leoni, Giovanna, Neumann, Philipp-Alexander, Geem, Duke, Lili, Loukia N, Ramadas, Ravisankar A, Chassaing, Benoit, Gewirtz, Andrew T, Kohlmeier, Jacob E, Parkos, Charles A, Towne, Jennifer E, Nusrat, Asma, Denning, Timothy L

“…IL-1 family members are central mediators of host defense. In this article, we show that the novel IL-1 family member IL-36γ was expressed during experimental…”
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Macrophage Isolation from the Mouse Small and Large Intestine by Harusato, Akihito, Geem, Duke, Denning, Timothy L

“…Macrophages play important roles in maintaining intestinal homeostasis via their ability to orchestrate responses to the normal microbiota as well as…”
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Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3 + Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis by Abo, Hirohito, Flannigan, Kyle L, Geem, Duke, Ngo, Vu L, Harusato, Akihito, Denning, Timothy L

“…Interleukin (IL)-2 is expressed during T cell activation and induces the proliferation and differentiation of T cells. CD4 Foxp3 regulatory T cells (Tregs)…”
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Resolution of recurrent pediatric acute liver failure with liver transplantation in a patient with NBAS mutation by Geem, Duke, Jiang, Wenxiao, Rytting, Heather B., Chandrakasan, Shanmuganathan, Salem, Anand, Stevens, James P., Karpen, Saul J., Magliocca, Joseph F., Romero, Rene, Rodriguez, Dellys Soler

“…Background Pediatric acute liver failure (PALF) remains an enigmatic process of rapid end‐organ dysfunction associated with a variety of pathologic conditions…”
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Small intestinal intraepithelial TCRγδ+ T lymphocytes are present in the premature intestine but selectively reduced in surgical necrotizing enterocolitis by Weitkamp, Jörn-Hendrik, Rosen, Michael J, Zhao, Zhiguo, Koyama, Tatsuki, Geem, Duke, Denning, Timothy L, Rock, Michael T, Moore, Daniel J, Halpern, Melissa D, Matta, Pranathi, Denning, Patricia W

“…Gastrointestinal barrier immaturity predisposes preterm infants to necrotizing enterocolitis (NEC). Intraepithelial lymphocytes (IEL) bearing the…”
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Phenotypic and functional profiling of mouse intestinal antigen presenting cells by Harusato, Akihito, Flannigan, Kyle L., Geem, Duke, Denning, Timothy L.

“…The microbiota that populates the mammalian intestine consists of hundreds of trillions of bacteria that are separated from underlying immune cells by a single…”
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Persistent Inflammation of the Rectum in Perianal Fistulizing Crohn's Disease Is Associated With Goblet Cell Function by Washburn, Savannah, Maddipatla, Sushma C, Murthy, Shanta, Dodd, Anne, Pelia, Ranjit S, Kolachala, Vasantha L, Geem, Duke, Matthews, Jason D, Gibson, Greg, Kugathasan, Subra

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It Takes Two to Make It Right: Dual Biologic and Small Molecule Therapy for Treatment-Refractory Pediatric Inflammatory Bowel Disease by Geem, Duke, Kugathasan, Subra

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Cortisol, stress, and attentional bias toward threat by McHugh, R. Kathryn, Behar, Evelyn, Gutner, Cassidy A., Geem, Duke, Otto, Michael W.

“…Attentional bias toward threatening stimuli is a central characteristic of anxiety and acute stress. Recent small-scale studies have provided divergent…”
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Targeting Intestinal Inflammation With CD98 siRNA/PEI–loaded Nanoparticles by Laroui, Hamed, Geem, Duke, Xiao, Bo, Viennois, Emilie, Rakhya, Poonam, Denning, Timothy, Merlin, Didier

“…Intestinal CD98 expression plays a crucial role in controlling homeostatic and innate immune responses in the gut. Modulation of CD98 expression in intestinal…”
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A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage by Ngo, Vu L., Abo, Hirohito, Maxim, Estera, Harusato, Akihito, Geem, Duke, Medina-Contreras, Oscar, Merlin, Didier, Gewirtz, Andrew T., Nusrat, Asma, Denning, Timothy L.

“…The gut epithelium acts to separate host immune cells from unrestricted interactions with the microbiota and other environmental stimuli. In response to…”
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866 PRO-INFLAMMATORY SIRPα-EXPRESSING MONOCYTES AND MACROPHAGES MEDIATE ANTI-TNF REFRACTORY CROHN'S DISEASE IN CHILDREN by Geem, Duke, Maddipatia, Sushma C., Pelia, Ranjit S., Matthews, Jason, Anbazhagan, Murugadas, Kolachala, Vasantha, Dodd, Ann, Kugathasan, Subra

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Su1735 PTGER4-PGE2 SIGNALING DRIVES EXPRESSION OF THE GOBLET CELL MARKER SPINK4 IN PATIENT-DERIVED INTESTINAL ORGANOIDS by Anbazhagan, Murugadas, Murthy, Shanta, Maddipatia, Sushma C., Geem, Duke, Kolachala, Vasantha, Dodd, Ann, Cutler, David J., Matthews, Jason, Kugathasan, Subra

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Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation by Flannigan, Kyle L, Geem, Duke, Harusato, Akihito, Denning, Timothy L

“…The microbiota that populate the mammalian intestine are critical for proper host physiology, yet simultaneously pose a potential danger. Intestinal…”
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PRO-INFLAMMATORY SIRPα-EXPRESSING MONOCYTES AND MACROPHAGES MEDIATE ANTI-TNF REFRACTORY CROHN'S DISEASE IN CHILDREN by Geem, Duke, Maddipatla, Sushma, Pelia, Ranjit, Venkateswaran, Suresh, Matthews, Jason, Anbazhagan, Murugadas, Kolachala, Vasantha, Dodd, Anne, Kugathasan, Subra

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Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization by Denning, Timothy L, Norris, Brian A, Medina-Contreras, Oscar, Manicassamy, Santhakumar, Geem, Duke, Madan, Rajat, Karp, Christopher L, Pulendran, Bali

“…Although several subsets of intestinal APCs have been described, there has been no systematic evaluation of their phenotypes, functions, and regional…”
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CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice by Medina-Contreras, Oscar, Geem, Duke, Laur, Oskar, Williams, Ifor R, Lira, Sergio A, Nusrat, Asma, Parkos, Charles A, Denning, Timothy L

“…The two most common forms of inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis, affect approximately 1 million people in the United…”
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12: MUCOSAL BIOPSY DERIVED MESENCHYMAL STROMAL CELLS DISPLAY FITNESS AND FUNCTIONALITY TO USE AS AUTOLOGOUS CELLULAR PHARMACEUTICALS FOR INFLAMMATORY BOWEL DISEASE by Anbazhagan, Murugadas, Geem, Duke, Venkateswaran, Suresh, Pelia, Ranjit S., Kolachala, Vasantha, Dodd, Ann, Matthews, Jason, Chinnadurai, Raghavan, Kugathasan, Subra

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PRO-INFLAMMATORY SIRPα-EXPRESSING MONOCYTES AND MACROPHAGES MEDIATE ANTI-TNF REFRACTORY CROHN'S DISEASE IN CHILDREN by Geem, Duke, Maddipatla, Sushma, Pelia, Ranjit, Venkateswaran, Suresh, Matthews, Jason, Anbazhagan, Murugadas, Kolachala, Vasantha, Dodd, Anne, Kugathasan, Subra

“…Abstract BACKGROUND Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract with detrimental consequences on the pediatric…”
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