Search Results - "Geduhn, Jens"

Characterization of mouse heart adenylyl cyclase by Göttle, Martin, Geduhn, Jens, König, Burkhard, Gille, Andreas, Höcherl, Klaus, Seifert, Roland

“…Chronic heart failure is one of the most frequent causes of death in humans. Knockout of type 5 adenylyl cyclase (AC) in mice causes longevity and protection…”
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Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides by Göttle, Martin, Dove, Stefan, Steindel, Phillip, Shen, Yuequan, Tang, Wei-Jen, Geduhn, Jens, König, Burkhard, Seifert, Roland

“…The calmodulin (CaM)-dependent adenylyl cyclase (AC) toxin from Bordetella pertussis (CyaA) substantially contributes to the pathogenesis of whooping cough…”
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Cytidylyl and Uridylyl Cyclase Activity of Bacillus anthracis Edema Factor and Bordetella pertussis CyaA by Göttle, Martin, Dove, Stefan, Kees, Frieder, Schlossmann, Jens, Geduhn, Jens, König, Burkhard, Shen, Yuequan, Tang, Wei-Jen, Kaever, Volkhard, Seifert, Roland

“…Cyclic adenosine 3′,5′-monophosphate (cAMP) and cyclic guanosine 3′,5′-monophosphate (cGMP) are second messengers for numerous mammalian cell functions. The…”
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Bis-halogen-anthraniloyl-substituted nucleoside 5'-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin by Geduhn, Jens, Dove, Stefan, Shen, Yuequan, Tang, Wei-Jen, König, Burkhard, Seifert, Roland

“…Whooping cough is caused by Bordetella pertussis and still constitutes one of the top five causes of death in young children, particularly in developing…”
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Structure–activity relationships for the interactions of 2′- and 3′-( O)-( N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases by Pinto, Cibele, Lushington, Gerald H., Richter, Mark, Gille, Andreas, Geduhn, Jens, König, Burkhard, Mou, Tung-Chung, Sprang, Stephen R., Seifert, Roland

“…We characterize interactions of 21 (M)ANT-nucleotides with mammalian adenylyl cyclases. Through combination of enzymological, fluorescence spectroscopy and…”
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Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5′-triphosphates by Taha, Hesham, Dove, Stefan, Geduhn, Jens, König, Burkhard, Shen, Yuequan, Tang, Wei-Jen, Seifert, Roland

“…Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins, i.e. lethal factor, protective antigen and…”
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Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides by Taha, Hesham M, Schmidt, Jennifer, Göttle, Martin, Suryanarayana, Srividya, Shen, Yuequan, Tang, Wei-Jen, Gille, Andreas, Geduhn, Jens, König, Burkhard, Dove, Stefan, Seifert, Roland

“…Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins: lethal factor, protective antigen, and edema…”
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Structural basis for the high-affinity inhibition of mammalian membranous adenylyl cyclase by 2',3'-o-(N-methylanthraniloyl)-inosine 5'-triphosphate by Hübner, Melanie, Dixit, Anshuman, Mou, Tung-Chung, Lushington, Gerald H, Pinto, Cibele, Gille, Andreas, Geduhn, Jens, König, Burkhard, Sprang, Stephen R, Seifert, Roland

“…2',3'-O-(N-Methylanthraniloyl)-ITP (MANT-ITP) is the most potent inhibitor of mammalian membranous adenylyl cyclase (mAC) 5 (AC5, K(i), 1 nM) yet discovered…”
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