Search Results - "Gederaas, Odrun A."

Gold Tris(carboxyphenyl)corroles as Multifunctional Materials: Room Temperature Near-IR Phosphorescence and Applications to Photodynamic Therapy and Dye-Sensitized Solar Cells by Alemayehu, Abraham B, Day, Nicholas U, Mani, Tomoyasu, Rudine, Alexander B, Thomas, Kolle E, Gederaas, Odrun A, Vinogradov, Sergei A, Wamser, Carl C, Ghosh, Abhik

“…Two amphiphilic corroles5,10,15-tris­(3-carboxy­phenyl)­corrole (H3[mTCPC]) and 5,10,15-tris­(4-carboxy­phenyl)­corrole (H3[pTCPC])and their gold complexes…”
Get full text

Homology modeling of human γ-butyric acid transporters and the binding of pro-drugs 5-aminolevulinic acid and methyl aminolevulinic acid used in photodynamic therapy by Baglo, Yan, Gabrielsen, Mari, Sylte, Ingebrigt, Gederaas, Odrun A

“…Photodynamic therapy (PDT) is a safe and effective method currently used in the treatment of skin cancer. In ALA-based PDT, 5-aminolevulinic acid (ALA), or ALA…”
Get full text

Influence of Polymer Charge on the Localization and Dark- and Photo-Induced Toxicity of a Potential Type I Photosensitizer in Cancer Cell Models by Lindgren, Mikael, Gederaas, Odrun A, Siksjø, Monica, Hansen, Tom A, Chen, Lena, Mettra, Bastien, Andraud, Chantal, Monnereau, Cyrille

“…A current trend within photo-dynamic therapy (PDT) is the development of molecular systems targeting hypoxic tumors. Thus, type I PDT sensitizers could here…”
Get full text

Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination by Haug, Markus, Brede, Gaute, Håkerud, Monika, Nedberg, Anne Grete, Gederaas, Odrun A, Flo, Trude H, Edwards, Victoria T, Selbo, Pål K, Høgset, Anders, Halaas, Øyvind

“…Effective priming and activation of tumor-specific CD8+ cytotoxic T lymphocytes (CTLs) is crucial for realizing the potential of therapeutic cancer…”
Get full text

Amphiphilic Rhenium-Oxo Corroles as a New Class of Sensitizers for Photodynamic Therapy by Einrem, Rune F, Alemayehu, Abraham B, Borisov, Sergey M, Ghosh, Abhik, Gederaas, Odrun A

“…A set of rhenium­(V)-oxo meso-triarylcorroles bearing ester and carboxylic acid functionalities were synthesized with a view to determining their potential for…”
Get full text

Ruthenium porphyrin-induced photodamage in bladder cancer cells by Bogoeva, Vanya, Siksjø, Monica, Sæterbø, Kristin G, Melø, Thor Bernt, Bjørkøy, Astrid, Lindgren, Mikael, Gederaas, Odrun A

“…Highlights • Photophysical properties of ruthenium(II) porphyrin, verified that the photosensitizer is capable of activating singlet oxygen. • In vitro…”
Get full text

Increased toxicity of amylin (Islet Amyloid Polypeptide) in beta cells induced by photochemical internalization by Rinku, Singh, Hals, Ingrid, Høgset, Anders, Grill, Valdemar, Gederaas, Odrun A.

“…•PCI technology can be a tool to induce endosomal rupture in clonal beta cells.•Exposure to human amylin and PCI together exerted toxic effects in beta…”
Get full text

Synthesis and in vitro evaluation of a novel thienopyrimidine with phototoxicity towards rat glioma F98 cells by Gederaas, Odrun A, Sørensen, Andreas S, Lindgren, Mikael, Melø, Thor Bernt, Altin, Dag, Flatby, Ellen MS, Høgset, Anders, Hoff, Bård Helge

“…•The compound N1-(4-(4-(Benzyl(methyl)amino)thieno[2,3-d]pyrimidin-6-yl)benzyl)-N2,N2-dimethylethane-1,2-diamine (compound 1) may be a novel class of…”
Get full text

Increased Anticancer Efficacy of Intravesical Mitomycin C Therapy when Combined with a PCNA Targeting Peptide by Gederaas, Odrun A, Søgaard, Caroline D, Viset, Trond, Bachke, Siri, Bruheim, Per, Arum, Carl-Jørgen, Otterlei, Marit

“…Abstract Non–muscle-invasive bladder cancers (NMIBCs) are tumors confined to the mucosa or the mucosa/submucosa. An important challenge in treatment of NMIBC…”
Get full text

In Vitro Cell Model Investigation of Alpha-Synuclein Aggregate Morphology Using Spectroscopic Imaging by Swaminathan, Priyanka, Klingstedt, Therése, Theologidis, Vasileios, Gram, Hjalte, Larsson, Johan, Hagen, Lars, Liabakk, Nina B., Gederaas, Odrun A., Hammarström, Per, Nilsson, K. Peter R., Van Den Berge, Nathalie, Lindgren, Mikael

“…Recently, it has been hypothesized that alpha-synuclein protein strain morphology may be associated with clinical subtypes of alpha-synucleinopathies, like…”
Get full text

"Two hits - one stone"; increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling by Søgaard, Caroline Krogh, Blindheim, Augun, Røst, Lisa M, Petrović, Voin, Nepal, Anala, Bachke, Siri, Liabakk, Nina-Beate, Gederaas, Odrun A, Viset, Trond, Arum, Carl-Jørgen, Bruheim, Per, Otterlei, Marit

“…Low response rate and rapid development of resistance against commonly used chemotherapeutic regimes demand new multi-targeting anti-cancer strategies. In this…”
Get full text

Red versus blue light illumination in hexyl 5-aminolevulinate photodynamic therapy: the influence of light color and irradiance on the treatment outcome in vitro by Helander, Linda, Krokan, Hans E, Johnsson, Anders, Gederaas, Odrun A, Plaetzer, Kristjan

“…Hexyl 5-aminolevulinate (HAL) is a lipophilic derivative of 5-aminolevulinate, a key intermediate in biosynthesis of the photosensitizer protoporphyrin IX…”
Get full text

Methadone enhances the effectiveness of 5‐aminolevulinic acid‐based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro by Shi, Lei, Buchner, Alexander, Pohla, Heike, Pongratz, Thomas, Rühm, Adrian, Zimmermann, Wolfgang, Gederaas, Odrun A., Zhang, Linglin, Wang, Xiuli, Stepp, Herbert, Sroka, Ronald

“…Although having shown promising clinical outcomes, the effectiveness of 5‐aminolevulinic acid‐based photodynamic therapy (ALA‐PDT) for squamous cell carcinoma…”
Get full text

Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells by Gederaas, Odrun A, Sharma, Animesh, Mbarak, Saide, Sporsheim, Bjørnar, Høgset, Anders, Bogoeva, Vanya, Slupphaug, Geir, Hagen, Lars

“…Photochemical internalization (PCI) is a promising new technology for site-specific drug delivery, developed from photodynamic therapy (PDT). In PCI,…”
Get more information

Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins by Helander, Linda, Sharma, Animesh, Krokan, Hans E, Plaetzer, Kristjan, Krammer, Barbara, Tortik, Nicole, Gederaas, Odrun A, Slupphaug, Geir, Hagen, Lars

“…Photodynamic therapy (PDT) is a highly selective two-step cancer treatment involving a photosensitizer and illumination with visible light in the presence of…”
Get more information

Enhanced Efficacy of Bleomycin in Bladder Cancer Cells by Photochemical Internalization by Baglo, Yan, Hagen, Lars, Høgset, Anders, Drabløs, Finn, Otterlei, Marit, Gederaas, Odrun A.

“…Bleomycin is a cytotoxic chemotherapeutic agent widely used in cancer treatment. However, its efficacy in different cancers is low, possibly due to limited…”
Get full text

Photochemical internalization of bleomycin and temozolomide--in vitro studies on the glioma cell line F98 by Gederaas, Odrun A, Hauge, Anette, Ellingsen, Pål G, Berg, Kristian, Altin, Dag, Bardal, Tora, Høgset, Anders, Lindgren, Mikael

“…Here we evaluate the photosensitizer meso-tetraphenyl chlorin disulphonate (TPCS2a) in survival studies of rat glioma cancer cells in combination with the…”
Get more information

Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model by Baglo, Yan, Ph.D, Peng, Qian, Hagen, Lars, Berg, Kristian, Høgset, Anders, Drabløs, Finn, Gederaas, Odrun A

“…Highlights • Pioneering study of the photosensitizer disulfonated meso-tetraphenyl chlorin in rat bladder tumor model. • Location, distribution and penetration…”
Get full text

Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways by Baglo, Yan, Sousa, Mirta M L, Slupphaug, Geir, Hagen, Lars, Håvåg, Sissel, Helander, Linda, Zub, Kamila A, Krokan, Hans E, Gederaas, Odrun A

“…Photodynamic therapy (PDT) using blue light and the potent precursor for protoporphyrin IX, hexyl aminolevulinate (HAL), has been shown to induce apoptosis and…”
Get more information

Monitoring of hexyl 5-aminolevulinate-induced photodynamic therapy in rat bladder cancer by optical spectroscopy by Larsen, Eivind L P, Randeberg, Lise L, Gederaas, Odrun A, Arum, Carl-Jørgen, Hjelde, Astrid, Zhao, Chun-Mei, Chen, Duan, Krokan, Hans E, Svaasand, Lars O

“…Monitoring of the tissue response to photodynamic therapy (PDT) can provide important information to help optimize treatment variables such as drug and light…”
Get more information