Search Results - "Geddings, Julia E"

Tumor-derived tissue factor–positive microparticles and venous thrombosis in cancer patients by Geddings, Julia E., Mackman, Nigel

“…Patients with cancer have an increased risk for venous thrombosis. Interestingly, different cancer types have different rates of thrombosis, with pancreatic…”
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New players in haemostasis and thrombosis by Geddings, Julia E, Mackman, Nigel

“…The blood coagulation cascade is essential for haemostasis, but excessive activation can cause thrombosis. Importantly, recent studies have identified factors…”
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Evaluation of venous thrombosis and tissue factor in epithelial ovarian cancer by Cohen, Joshua G, Prendergast, Emily, Geddings, Julia E, Walts, Ann E, Agadjanian, Hasmik, Hisada, Yohei, Karlan, Beth Y, Mackman, Nigel, Walsh, Christine S

“…Abstract Objective Ovarian clear cell carcinoma (OCCC) and high grade serous ovarian cancer (HGSOC) are associated with the highest risk of VTE among patients…”
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Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer by Wang, Jian-Guo, Geddings, Julia E., Aleman, Maria M., Cardenas, Jessica C., Chantrathammachart, Pichika, Williams, Julie C., Kirchhofer, Daniel, Bogdanov, Vladimir Y., Bach, Ronald R., Rak, Janusz, Church, Frank C., Wolberg, Alisa S., Pawlinski, Rafal, Key, Nigel S., Yeh, Jen Jen, Mackman, Nigel

“…Cancer patients often have an activated clotting system and are at increased risk for venous thrombosis. In the present study, we analyzed tissue factor (TF)…”
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Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm by Owens, A Phillip, Edwards, Todd L, Antoniak, Silvio, Geddings, Julia E, Jahangir, Eiman, Wei, Wei-Qi, Denny, Joshua C, Boulaftali, Yacine, Bergmeier, Wolfgang, Daugherty, Alan, Sampson, Uchechukwu K.A, Mackman, Nigel

“…OBJECTIVE—Rupture of abdominal aortic aneurysms causes a high morbidity and mortality in the elderly population. Platelet-rich thrombi form on the surface of…”
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Comment on "tissue factor expressed by microparticles is associated with mortality but not with thrombosis in cancer patients" by Geddings, Julia E, Mackman, Nigel

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Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo by Lopez, Michelle, Kopec, Anna K, Joshi, Nikita, Geddings, Julia E, Cline, Holly, Towery, Keara L, Rockwell, Cheryl E, Mackman, Nigel, Luyendyk, James P

“…Hepatocyte (HPC) apoptosis occurs in association with hepatotoxic responses and chronic liver disease, and is coupled to activation of the blood coagulation…”
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Tissue factor–positive tumor microvesicles activate platelets and enhance thrombosis in mice by Geddings, J. E., Hisada, Y., Boulaftali, Y., Getz, T. M., Whelihan, M., Fuentes, R., Dee, R., Cooley, B. C., Key, N. S., Wolberg, A. S., Bergmeier, W., Mackman, N.

“…Essentials Cancer patients have a high rate of venous thrombosis (VT) but the underlying mechanisms are unknown. Tumor‐derived, tissue factor‐positive…”
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Relationship between tissue factor expression by human pancreatic cancer cells and activation of coagulation and thrombosis in a mouse model by Geddings, Julia E., Wang, Jian-guo, Cardenas, Jessica C, Chantrathammachart, Pichika, Williams, Julie C, Back, Ronald R, Church, Frank C, Pawlinski, Rafal, Key, Nigel, Yeh, Jen Jen, Mackman, Nigel

“…Abstract only e14505 Background: The increased risk of thrombosis in patients with cancer has been well established. However, the triggers in these patients…”
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The role of tumor microparticles in cancer-associated thrombosis by Geddings, Julia E

“…Cancer patients have a ∼4 -fold increased risk of venous thromboembolism (VTE) compared with the general population, and cancer patients with VTE have reduced…”
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The role of tumor microparticles in cancer-associated thrombosis by Geddings, Julia E

“…Cancer patients have a ∼4 -fold increased risk of venous thromboembolism (VTE) compared with the general population, and cancer patients with VTE have reduced…”
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