Search Results - "Geczy, CL"

Oxidative modifications of S100 proteins: functional regulation by redox by Lim, Su Yin, Raftery, Mark J., Goyette, Jesse, Hsu, Kenneth, Geczy, Carolyn L.

“…Alterations in the capability of CF lung macrophage to respond and clear airway pathogens might contribute to the development of lung disease in cystic…”
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S100A8 and S100A9 in human arterial wall. Implications for atherogenesis by McCormick, Michelle M, Rahimi, Farid, Bobryshev, Yuri V, Gaus, Katharina, Zreiqat, Hala, Cai, Hong, Lord, Reginald S A, Geczy, Carolyn L

“…Atherogenesis is a complex process involving inflammation. S100A8 and S100A9, the Ca2+-binding neutrophil cytosolic proteins, are associated with innate…”
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Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis by Chen, Yueh-Sheng, Yan, Weixing, Geczy, Carolyn L, Brown, Matthew A, Thomas, Ranjeny

“…The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface receptor molecules. High concentrations…”
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S100A8 modulates mast cell function and suppresses eosinophil migration in acute asthma by Zhao, Jing, Endoh, Ikuko, Hsu, Kenneth, Tedla, Nicodemus, Endoh, Yasumi, Geczy, Carolyn L

“…S100A8 is implicated in the pathogenesis of inflammatory diseases. S100A8 is upregulated in macrophages by Toll-like receptors (TLR)-3, 4, and 9 agonists in an…”
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Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease by Shepherd, C.E., Goyette, J., Utter, V., Rahimi, F., Yang, Z., Geczy, C.L., Halliday, G.M.

“…Inflammation, insoluble protein deposition and neuronal cell loss are important features of the Alzheimer's disease (AD) brain. S100B is associated with the…”
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Inflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cells by Zuo, Yunxia, Perkins, Nicholas M, Tracey, David J, Geczy, Carolyn L

“…Inflammatory cells and their mediators are known to contribute to neuropathic pain following nerve injury. Mast cells play a key role in non-neural models of…”
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FGF‐2, IL‐1β and TGF‐β regulate fibroblast expression of S100A8 by Rahimi, Farid, Hsu, Kenneth, Endoh, Yasumi, Geczy, Carolyn L.

“…Growth factors, including fibroblast growth factor‐2 (FGF‐2) and transforming growth factor‐β (TGF‐β) regulate fibroblast function, differentiation and…”
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Induction of the Chemotactic S100 Protein, CP-10, in Monocyte/Macrophages by Lipopolysaccharide by Hu, Sheng-Ping, Harrison, Craig, Xu, Ken, Cornish, Coralie J., Geczy, Carolyn L.

“…The murine S100 protein CP-10 is a potent chemotactic factor for murine and human myeloid cells in vivo and in vitro. This is the first report describing…”
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IFN-gamma and TNF regulate macrophage expression of the chemotactic S100 protein S100A8 by Xu, K, Geczy, C L

“…The murine calcium-binding protein S100A8 is a potent chemoattractant for neutrophils and monocytes in vivo and in vitro but may also play a protective role…”
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Regulation of S100A8 by Glucocorticoids by Hsu, Kenneth, Passey, Robert J, Endoh, Yasumi, Rahimi, Farid, Youssef, Peter, Yen, Tina, Geczy, Carolyn L

“…S100A8 (A8) has roles in inflammation, differentiation and development and is associated with oxidative defense. Murine A8 (mA8) is up-regulated in…”
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Proinflammatory properties of the human S100 protein S100A12 by Yang, Zheng, Tao, Tony, Raftery, Mark J., Youssef, Peter, Di Girolamo, Nick, Geczy, Carolyn L.

“…S100 proteins represent a new class of chemoattractants. Here we extend earlier evidence for the proinflammatory properties of human S100A12. A12 induced…”
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Interferon-γ and lipopolysaccharide potentiate monocyte tissue factor induction by C-reactive protein : Relationship with age, sex, and hormone replacement treatment by NAKAGOMI, A, BEN FREEDMAN, S, GECZY, C. L

“…Elevated plasma levels of C-reactive protein (CRP) in population studies and in patients with unstable coronary syndromes are predictive of future adverse…”
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Differential expression of leukocyte immunoglobulin-like receptors on cord blood-derived human mast cell progenitors and mature mast cells by Tedla, Nicodemus, Lee, Chyh‐Woei, Borges, Luis, Geczy, Carolyn L., Arm, Jonathan P.

“…The leukocyte Ig‐like receptors (LILRs) comprise a family of cell‐surface immunoregulatory receptors with activating and inhibitory members. The inhibitory…”
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S100A8/S100A9 and their association with cartilage and bone by Zreiqat, H, Howlett, C R, Gronthos, S, Hume, D, Geczy, C L

“…S100A8 and S100A9 are calcium-binding proteins expressed in myeloid cells and are markers of numerous inflammatory diseases in humans. S100A9 has been…”
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Novel Intra- and Inter-molecular Sulfinamide Bonds in S100A8 Produced by Hypochlorite Oxidation by Raftery, Mark J., Yang, Zheng, Valenzuela, Stella M., Geczy, Carolyn L.

“…Hypochlorite is a major oxidant generated when neutrophils and macrophages are activated at inflammatory sites, such as in atherosclerotic lesions. Murine…”
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IL-10 Up-Regulates Macrophage Expression of the S100 Protein S100A8 by Xu, Ken, Yen, Tina, Geczy, Carolyn L

“…The murine calcium binding protein S100A8 (A8) is a leukocyte chemoattractant, but high levels may be protective and scavenge hypochlorite. A8 is induced by…”
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S100A8 Induction in Keratinocytes by Ultraviolet A Irradiation Is Dependent on Reactive Oxygen Intermediates by Grimbaldeston, Michele A., Geczy, Carolyn L., Tedla, Nicodemus, Finlay-Jones, John J., Hart, Prue H.

“…Cutaneous exposure to ultraviolet (UV) A (320–400 nm) results in the formation of damaging reactive oxygen intermediates, which are implicated as mediators of…”
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A Null Mutation in the Inflammation-Associated S100 Protein S100A8 Causes Early Resorption of the Mouse Embryo by Passey, Robert J, Williams, Elizabeth, Lichanska, Agnieszka M, Wells, Christine, Hu, Shengping, Geczy, Carolyn L, Little, Melissa H, Hume, David A

“…S100A8 (also known as CP10 or MRP8) was the first member of the S100 family of calcium-binding proteins shown to be chemotactic for myeloid cells. The gene is…”
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Antigen-Epitope Retrieval To Facilitate Proteomic Analysis of Formalin-Fixed Archival Brain Tissue by Rahimi, F, Shepherd, C. E, Halliday, G. M, Geczy, C. L, Raftery, M. J

“…Formalin is a routine fixative facilitating tissue preservation and histopathology. Proteomic techniques require freshly frozen specimens, which are often…”
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S100A8: emerging functions and regulation by Passey, Robert J., Xu, Ken, Hume, David A., Geczy, Carolyn L.

“…The functional importance of members of the S100 Ca2+‐binding protein family is becoming apparent. Murine (m)S100A8 (initially named CP‐10) is a potent…”
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