The use of rats to detect drug-resistant TB

Although detection of drug-susceptible TB by Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling-trained African giant pouched rats has been known for more than a decade, the detection of drug-resistant TB (DR-TB) using rats has never been explored before. We present what we believe to be the first...

Full description

Saved in:

Bibliographic Details
Published in:	Public health action Vol. 13; no. 1; pp. 1 - 3
Main Authors:	Beyene, N., Sitotaw, A. L., Telila, E. G., Gebre, H. A., Alemu, N. B., Burny, R., Cox, C., Soka, J., Tegegn, B., Wassie, L., Bobosha, K., Agizew, T.
Format:	Journal Article
Language:	English
Published:	France International Union Against Tuberculosis and Lung Disease 21-03-2023
Subjects:	African Giant Pouched Rats rifampicin resistance Short Communication Tb Detection Tuberculosis Xpert MTB/RIF Ultra African giant pouched rats TB detection rifampicin resistance tuberculosis Xpert MTB/RIF Ultra
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Although detection of drug-susceptible TB by Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling-trained African giant pouched rats has been known for more than a decade, the detection of drug-resistant TB (DR-TB) using rats has never been explored before. We present what we believe to be the first report on rifampicin-resistant TB (RR-TB) detected using Xpert® MTB/RIF Ultra, comparably identified by rats sniffing sputum samples from presumptive TB patients: 88% of RR-TB detected using Ultra were identified by the rats. Further evaluation of the usefulness of rats for large-scale DR-TB contact triage testing is needed, especially in low- and middle-income countries, where resources are limited.
Bibliography:	2220-8372(20230321)13:1L.1;1- ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2220-8372 2220-8372
DOI:	10.5588/pha.22.0059