Deposition of inspired aerosol particles within the respiratory tract of patients with obstructive lung disease

Deposition of inspired aerosol particles within the respiratory tract of patients with obstructive lung disease

Total deposition of monodisperse aerosol particles in the size range between 1 μm and 3 μm was measured in patients with obstructive lung disease and in normal people using equal breathing conditions for both groups. It turns out that for breathing conditions at rest, deposition for patients is high...

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Bibliographic Details
Published in:Toxicology Letters Vol. 88; no. 1; pp. 255 - 261
Main Authors: Schiller-scotland, Christiane F., Gebhart, Josef, Hochrainer, Dieter, Siekmeier, Rüdiger
Format: Journal Article Conference Proceeding
Language:English
Published: Shannon Elsevier Ireland Ltd 01-11-1996
Amsterdam Elsevier Science
Subjects:
Aerosols - analysis
Biological and medical sciences
Chronic obstructive pulmonary disease, asthma
Humans
Lung - anatomy & histology
Lung - physiology
Lung Diseases, Obstructive - drug therapy
Lung Diseases, Obstructive - physiopathology
Lung function tests
Medical sciences
Obstructive lung disease
Particle Size
Pneumology
Respiration - physiology
Respiratory Function Tests - methods
Total deposition
Total deposition
Obstructive lung disease
Lung function tests
Human
Respiratory tract
Lung disease
Particle size
Lung function
Respiratory disease
Aerosol deposition
Obstructive pulmonary disease
Normal
Monodispersed aerosol
Comparative study
Inhalation
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Description
Summary:Total deposition of monodisperse aerosol particles in the size range between 1 μm and 3 μm was measured in patients with obstructive lung disease and in normal people using equal breathing conditions for both groups. It turns out that for breathing conditions at rest, deposition for patients is higher, especially in the case of 1 μm particles. A second breathing pattern similar to forced exercise, but including a breath holding interval of 6 s after inhalation, is applied to throw some light on the effect of time-dependent deposition mechanisms. The results show less differences between both groups, indicating that enhanced gravitational deposition during respiratory pauses compensates for differences in lung morphometry.
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ISSN:0378-4274
1879-3169
DOI:10.1016/0378-4274(96)03747-2