Search Results - "Gebhart, J J"

11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial by Cameron, David, Prof, Piccart-Gebhart, Martine J, PhD, Gelber, Richard D, PhD, Procter, Marion, PhD, Goldhirsch, Aron, MD, de Azambuja, Evandro, MD, Castro, Gilberto, MD, Untch, Michael, MD, Smith, Ian, MD, Gianni, Luca, MD, Baselga, Jose, MD, Al-Sakaff, Nedal, PhD, Lauer, Sabine, PhD, McFadden, Eleanor, MA, Leyland-Jones, Brian, MBBS, Bell, Richard, MBBS, Dowsett, Mitch, PhD, Jackisch, Christian, MD

“…Summary Background Clinical trials have shown that trastuzumab, a recombinant monoclonal antibody against HER2 receptor, significantly improves overall…”
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Mechanisms of resistance to trastuzumab emtansine (T-DM1) in HER2-positive breast cancer by Hunter, Francis W., Barker, Hilary R., Lipert, Barbara, Rothé, Françoise, Gebhart, Géraldine, Piccart-Gebhart, Martine J., Sotiriou, Christos, Jamieson, Stephen M. F.

“…The HER2-targeted antibody–drug conjugate trastuzumab emtansine (T-DM1) is approved for the treatment of metastatic, HER2-positive breast cancer after prior…”
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Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer by Saini, Kamal S, Loi, Sherene, de Azambuja, Evandro, Metzger-Filho, Otto, Saini, Monika Lamba, Ignatiadis, Michail, Dancey, Janet E, Piccart-Gebhart, Martine J

“…Summary Alterations of signal transduction pathways leading to uncontrolled cellular proliferation, survival, invasion, and metastases are hallmarks of the…”
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Differences in Medial and Lateral Posterior Tibial Slope: An Osteological Review of 1090 Tibiae Comparing Age, Sex, and Race by Weinberg, Douglas S., Williamson, Drew F.K., Gebhart, Jeremy J., Knapik, Derrick M., Voos, James E.

“…Background: Injuries to the anterior cruciate ligament (ACL) are common, and a number of knee morphological variables have been identified as risk factors for…”
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Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12 155 patients by DE AZAMBUJA, E, CARDOSO, F, DE CASTRO JR, G, COLOZZA, M, MANO, M. S, DURBECQ, V, SOTIRIOU, C, LARSIMONT, D, PICCART-GEBHART, M. J, PAESMANS, M

“…The Ki-67 antigen is used to evaluate the proliferative activity of breast cancer (BC); however, Ki-67's role as a prognostic marker in BC is still undefined…”
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Clinical Application of the 70-Gene Profile: The MINDACT Trial by Cardoso, Fatima, Van't Veer, Laura, Rutgers, Emiel, Loi, Sherene, Mook, Stella, Piccart-Gebhart, Martine J

“…The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer…”
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Comparative analysis of Streptococcus suis genomes identifies novel candidate virulence-associated genes in North American isolates by Estrada, April A, Gottschalk, Marcelo, Gebhart, Connie J, Marthaler, Douglas G

“…Streptococcus suis is a significant economic and welfare concern in the swine industry. Pan-genome analysis provides an in-silico approach for the discovery of…”
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Trastuzumab-Associated Cardiac Events at 8 Years of Median Follow-Up in the Herceptin Adjuvant Trial (BIG 1-01) by DE AZAMBUJA, Evandro, PROCTER, Marion J, JACKISCH, Christian, CAMERON, David A, BELL, Richard, LEYLAND-JONES, Brian, DOWSETT, Mitch, GELBER, Richard D, PICCART-GEBHART, Martine J, SUTER, Thomas M, VAN VELDHUISEN, Dirk J, AGBOR-TARH, Dominique, METZGER, Otto, STEINSEIFER, Jutta, UNTCH, Michael, SMITH, Ian E, GIANNI, Luca, BASELGA, Jose

“…To document the rate and outcome of trastuzumab-associated cardiac dysfunction in patients following 1 or 2 years of adjuvant therapy. The Herceptin Adjuvant…”
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Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial by Gianni, Luca, Prof, Dafni, Urania, Prof, Gelber, Richard D, Prof, Azambuja, Evandro, PhD, Muehlbauer, Susanne, PhD, Goldhirsch, Aron, Prof, Untch, Michael, Prof, Smith, Ian, Prof, Baselga, José, Prof, Jackisch, Christian, Prof, Cameron, David, Prof, Mano, Max, MD, Pedrini, José Luiz, MD, Veronesi, Andrea, Prof, Mendiola, Cesar, MD, Pluzanska, Anna, Prof, Semiglazov, Vladimir, MD, Vrdoljak, Eduard, MD, Eckart, Michael J, MD, Shen, Zhenzhou, Prof, Skiadopoulos, George, MSci, Procter, Marion, MSci, Pritchard, Kathleen I, MD, Piccart-Gebhart, Martine J, PhD, Bell, Richard, MBBS

“…Summary Background Treatment with adjuvant trastuzumab for 1 year improves disease-free survival and overall survival in patients with human epidermal growth…”
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Pelvic incidence: an anatomic investigation of 880 cadaveric specimens by Weinberg, Douglas S., Morris, William Z., Gebhart, Jeremy J., Liu, Raymond W.

“…Purpose Pelvic incidence is a position- and posture-independent parameter used to quantify sagittal balance of the spine, sacrum, pelvis and hips. Its…”
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Relationship between pelvic incidence and osteoarthritis of the hip by Gebhart, J J, Weinberg, D S, Bohl, M S, Liu, R W

“…Sagittal alignment of the lumbosacral spine, and specifically pelvic incidence (PI), has been implicated in the development of spine pathology, but generally…”
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Changes in the Porcine Intestinal Microbiome in Response to Infection with Salmonella enterica and Lawsonia intracellularis by Borewicz, Klaudyna A, Kim, Hyeun Bum, Singer, Randall S, Gebhart, Connie J, Sreevatsan, Srinand, Johnson, Timothy, Isaacson, Richard E

“…Salmonella enterica is a leading cause of food borne illness. Recent studies have shown that S. enterica is a pathogen capable of causing alterations to the…”
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Pertuzumab: new hope for patients with HER2-positive breast cancer by Capelan, M., Pugliano, L., De Azambuja, E., Bozovic, I., Saini, K.S., Sotiriou, C., Loi, S., Piccart-Gebhart, M.J.

“…Human epidermal growth factor receptor 2 (HER2) overexpression is detected in approximately 15% to 20% of all breast cancers (BCs). A revolutionary change in…”
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Role of the multidisciplinary team in breast cancer management: results from a large international survey involving 39 countries by Saini, K.S., Taylor, C., Ramirez, A.-J., Palmieri, C., Gunnarsson, U., Schmoll, H.J., Dolci, S.M., Ghenne, C., Metzger-Filho, O., Skrzypski, M., Paesmans, M., Ameye, L., Piccart-Gebhart, M.J., de Azambuja, E.

“…The optimal management of patients with breast cancer (BC) requires the expertise of specialists from different disciplines. This has led to the evolution of…”
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Radiographic Signs of Femoroacetabular Impingement Are Associated With Decreased Pelvic Incidence by Weinberg, Douglas S., M.D, Gebhart, Jeremy J., M.D, Liu, Raymond W., M.D, Salata, Michael J., M.D

“…Purpose To investigate the relation between cam, acetabular version, and pelvic incidence. Methods This was a retrospective analysis of 65 patients with…”
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CNS relapses in patients with HER2-positive early breast cancer who have and have not received adjuvant trastuzumab: a retrospective substudy of the HERA trial (BIG 1-01) by Pestalozzi, Bernhard C, Prof, Holmes, Eileen, PhD, de Azambuja, Evandro, MD, Metzger-Filho, Otto, MD, Hogge, Laurence, MSc, Scullion, Matt, PhD, Láng, István, Prof, Wardley, Andrew, MD, Lichinitser, Mikhail, MD, Sanchez, Roberto I Lopez, MD, Müller, Volkmar, Prof, Dodwell, David, MD, Gelber, Richard D, Prof, Piccart-Gebhart, Martine J, Prof, Cameron, David, Prof

“…Summary Background Several randomised trials have confirmed the benefit of adjuvant trastuzumab for patients with HER2-positive early breast cancer. However,…”
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Effect of Age on Breast Cancer Outcomes in Women With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: Results From a Herceptin Adjuvant Trial by PARTRIDGE, Ann H, GELBER, Shari, PICCART-GEBHART, Martine J, FOCANT, Florine, SCULLION, Matthew, HOLMES, Eileen, WINER, Eric P, GELBER, Richard D

“…Previous research has suggested that young age at diagnosis is an independent risk factor for breast cancer recurrence and death. No prior studies have…”
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Trastuzumab-Associated Cardiac Adverse Effects in the Herceptin Adjuvant Trial by Suter, Thomas M, Procter, Marion, van Veldhuisen, Dirk J, Muscholl, Michael, Bergh, Jonas, Carlomagno, Chiara, Perren, Timothy, Passalacqua, Rodolfo, Bighin, Claudia, Klijn, Jan G M, Ageev, Fail T, Hitre, Erika, Groetz, Juergen, Iwata, Hiroji, Knap, Malgorzata, Gnant, Michael, Muehlbauer, Susanne, Spence, Alison, Gelber, Richard D, Piccart-Gebhart, Martine J

“…The purpose of this analysis was to investigate trastuzumab-associated cardiac adverse effects in breast cancer patients after completion of (neo)adjuvant…”
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High proportion of patients with bleeding of unknown cause in persons with a mild‐to‐moderate bleeding tendency: Results from the Vienna Bleeding Biobank (VIBB) by Gebhart, J., Hofer, S., Panzer, S., Quehenberger, P., Sunder‐Plassmann, R., Hoermann, G., Eigenbauer, E., Haslacher, H., Kepa, S., Kyrle, P. A., Eichinger, S., Knöbl, P., Eischer, L., Mannhalter, C., Ay, C., Pabinger, I.

“…Introduction Data on clinical characteristics and the prevalence of underlying coagulopathies in patients with mild‐to‐moderate bleeding disorders (MBDs) are…”
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Understanding the molecular epidemiology and global relationships of Brachyspira hyodysenteriae from swine herds in the United States: a multi-locus sequence typing approach by Mirajkar, Nandita S, Gebhart, Connie J

“…Outbreaks of mucohemorrhagic diarrhea in pigs caused by Brachyspira hyodysenteriae in the late 2000s indicated the re-emergence of Swine Dysentery (SD) in the…”
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