Search Results - "Gebbink, Martijn F.B.G."

Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation by Maas, Coen, Govers-Riemslag, José W P, Bouma, Barend, Schiks, Bettina, Hazenberg, Bouke P C, Lokhorst, Henk M, Hammarström, Per, ten Cate, Hugo, de Groot, Philip G, Bouma, Bonno N, Gebbink, Martijn F B G

“…When blood is exposed to negatively charged surface materials such as glass, an enzymatic cascade known as the contact system becomes activated. This cascade…”
Get full text

Amyloids - a functional coat for microorganisms by Wösten, Han A. B, Gebbink, Martijn F.B.G, Claessen, Dennis, Bouma, Barend, Dijkhuizen, Lubbert

“…Amyloids are filamentous protein structures approximately 10 nm wide and 0.1-10 mum long that share a structural motif, the cross-beta structure. These fibrils…”
Get full text

A Role for Protein Misfolding in Immunogenicity of Biopharmaceuticals by Maas, Coen, Hermeling, Suzanne, Bouma, Barend, Jiskoot, Wim, Gebbink, Martijn F.B.G.

“…For largely unknown reasons, biopharmaceuticals evoke potentially harmful antibody formation. Such antibodies can inhibit drug efficacy and, when directed…”
Get full text

Activation of Human Platelets by Misfolded Proteins by Herczenik, Eszter, Bouma, Barend, Korporaal, Suzanne J.A, Strangi, Remo, Zeng, Qinghong, Gros, Piet, Van Eck, Miranda, Van Berkel, Theo J.C, Gebbink, Martijn F.B.G, Akkerman, Jan-Willem N

“…OBJECTIVE—Protein misfolding diseases result from the deposition of insoluble protein aggregates that often contain fibrils called amyloid. Amyloids are found…”
Get full text

The Filament-specific Rep1-1 Repellent of the Phytopathogen Ustilago maydis Forms Functional Surface-active Amyloid-like Fibrils by Teertstra, Wieke R., van der Velden, Gisela J., de Jong, Jan F., Kruijtzer, John A.W., Liskamp, Rob M.J., Kroon-Batenburg, Loes M.J., Müller, Wally H., Gebbink, Martijn F.B.G., Wösten, Han A.B.

“…Repellents of the maize pathogen Ustilago maydis are involved in formation of hydrophobic aerial hyphae and in cellular attachment. These peptides, called…”
Get full text

Molecular and cellular aspects of protein misfolding and disease by Herczenik, Eszter, Gebbink, Martijn F.B.G

“…Proteins are essential elements for life. They are building blocks of all organisms and the operators of cellular functions. Humans produce a repertoire of at…”
Get full text

Antibody response to aggregated human interferon alpha2b in wild-type and transgenic immune tolerant mice depends on type and level of aggregation by Hermeling, Suzanne, Schellekens, Huub, Maas, Coen, Gebbink, Martijn F B G, Crommelin, Daan J A, Jiskoot, Wim

“…The aim of this study was to determine the sensitivity of transgenic immune tolerant mice for the type and level of aggregation of recombinant human interferon…”
Get more information

Physiological responses to protein aggregates: Fibrinolysis, coagulation and inflammation (new roles for old factors) by Gebbink, Martijn F.B.G., Bouma, Barend, Maas, Coen, Bouma, Bonno N.

“…Misfolding is an inherent and potentially problematic propensity of proteins. Misfolded proteins tend to aggregate and the deposition of aggregated proteins is…”
Get full text

Recombinant endostatin forms amyloid fibrils that bind and are cytotoxic to murine neuroblastoma cells in vitro by Kranenburg, Onno, Kroon-Batenburg, Loes M.J, Reijerkerk, Arie, Wu, Ya-Ping, Voest, Emile E, Gebbink, Martijn F.B.G

“…Endostatin is a fragment of collagen XVIII that acts as an endogenous inhibitor of tumor angiogenesis and tumor growth. Anti-tumor effects have been described…”
Get full text

Identification of a Novel, Putative Rho-Specific GDP/GTP Exchange Factor and a RhoA-Binding Protein: Control of Neuronal Morphology by Martijn F. B. G. Gebbink, Kranenburg, Onno, Poland, Mieke, Francis P. G. van Horck, Houssa, Brahim, Moolenaar, Wouter H.

“…The small GTP-binding protein Rho has been implicated in the control of neuronal morphology. In N1E-115 neuronal cells, the Rho-inactivating C3 toxin…”
Get full text

Fibronectin is a hypoxia-independent target of the tumor suppressor VHL by Bluyssen, Hans A.R., Lolkema, Martijn P.J.K., van Beest, Moniek, Boone, Michelle, Snijckers, Cristel M.J.T., Los, Maartje, Gebbink, Martijn F.B.G., Braam, Branko, Holstege, Frank C.P., Giles, Rachel H., Voest, Emile E.

“…The von Hippel–Lindau ( VHL) tumor suppressor gene regulates the extracellular matrix by controlling fibronectin deposition. To identify novel VHL target…”
Get full text

Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase by Gebbink, Martijn F.B.G., van Etten, Ingrid, Hateboer, Guus, Suijkerbuijk, Ron, Beijersbergen, Roderick L., van Kessell, Ad Geurts, Moolenaar, Wouter H.

“…We have isolated a mouse cDNA of 5.7 kb, encoding a new member of the family of receptor-like protein tyrosine phosphatases, termed mRPTPμ. The cDNA predicts a…”
Get full text

p116 Is A Novel Filamentous Actin-binding Protein by Mulder, Jacqueline, Poland, Mieke, Gebbink, Martijn F.B.G., Calafat, Jero, Moolenaar, Wouter H., Kranenburg, Onno

Get full text

Glycation Induces Formation of Amyloid Cross-β Structure in Albumin by Bouma, Barend, Kroon-Batenburg, Loes M.J., Wu, Ya-Ping, Brünjes, Bettina, Posthuma, George, Kranenburg, Onno, de Groot, Philip G., Voest, Emile E., Gebbink, Martijn F.B.G.

“…Amyloid fibrils are components of proteinaceous plaques that are associated with conformational diseases such as Alzheimer's disease, transmissible spongiform…”
Get full text

Stimulation of angiogenesis by Ras proteins by Kranenburg, Onno, Gebbink, Martijn F.B.G., Voest, Emile E.

“…Cells that have acquired a proliferative advantage form islets of hyperplasia during the initial stages of tumor development. Like normal cells, they require…”
Get full text

A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain‐derived synaptic plasticity‐disrupting Aβ by O’Nuallain, Brian, Klyubin, Igor, Mc Donald, Jessica M., Foster, James S., Welzel, Alfred, Barry, Andrew, Dykoski, Richard K., Cleary, James P., Gebbink, Martijn F.B.G., Rowan, Michael J., Walsh, Dominic M.

“…J. Neurochem. (2011) 119, 189–201. Diverse lines of evidence indicate that pre‐fibrillar, diffusible assemblies of the amyloid β‐protein (Aβ) play an important…”
Get full text

Liver regeneration is an angiogenesis-associated phenomenon by DRIXLER, Tom A, VOGTEN, Mathys J, BROELSCH, C. E, RITCHIE, Ewan D, VAN VROONHOVEN, Theo J. M. V, GEBBINK, Martijn F. B. G, VOEST, Emile E, BOREL RINKES, Inne H. M, NEUHAUS, P, DRIXLER, T, CLAVIEN, P.-A

“…To investigate whether liver regeneration is an angiogenesis-associated phenomenon. Angiogenesis is predominantly known for its pivotal role in tumor growth…”
Get full text

Vascular endothelial growth factor–stimulated endothelial cells promote adhesion and activation of platelets by Verheul, Henk M.W., Jorna, Anita S., Hoekman, Klaas, Broxterman, Henk J., Gebbink, Martijn F.B.G., Pinedo, Herbert M.

“…Coagulation abnormalities, including an increased platelet turnover, are frequently found in patients with cancer. Because platelets secrete angiogenic factors…”
Get full text

Tissue-Type Plasminogen Activator Is a Multiligand Cross-β Structure Receptor by Kranenburg, Onno, Bouma, Barend, Kroon-Batenburg, Loes M.J., Reijerkerk, Arie, Wu, Ya-Ping, Voest, Emile E., Gebbink, Martijn F.B.G.

“…Tissue-type plasminogen activator (tPA) regulates fibrin clot lysis by stimulating the conversion of plasminogen into the active protease plasmin [1]. Fibrin…”
Get full text

A monoclonal antibody against synthetic A[beta] dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting A[beta] by O'Nuallain, Brian, Klyubin, Igor, Mc Donald, Jessica M, Foster, James S, Welzel, Alfred, Barry, Andrew, Dykoski, Richard K, Cleary, James P, Gebbink, Martijn F.B.G, Rowan, Michael J, Walsh, Dominic M

“…J. Neurochem. (2011) 119, 189-201. Abstract Diverse lines of evidence indicate that pre-fibrillar, diffusible assemblies of the amyloid β-protein (Aβ) play an…”
Get full text