Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome

To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome. A total of 35 rats were divided into control, sham, and experimental HPS groups. We eva...

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Published in:Acta cirurgica brasileira Vol. 29; no. 9; pp. 573 - 578
Main Authors: Nacif, Lucas Souto, Andraus, Wellington, Kubrusly, Márcia Saldanha, Kubrusly, Flávia Saldanha, Gebara, Vera Cristina Bugelli Cainelli, Ishizawa, Andrea, D'Albuquerque, Luiz Augusto Carneiro
Format: Journal Article
Language:English
Published: Brazil Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01-09-2014
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Summary:To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome. A total of 35 rats were divided into control, sham, and experimental HPS groups. We evaluated surfactant protein A levels in rats and the experimental model designed to induce hepatopulmonary syndrome was common bile duct ligation. Statistical analysis was performed using GraphPad Prism Software(r). Differences were considered statistically significant when p<0.05. Lung homogenate of surfactant protein A levels were lower in the experimental hepatopulmonary syndrome and sham groups in comparison to the control group (p<0.05). Serum SP-A levels were the same in experimental hepatopulmonary syndrome and control groups but decreased in the sham group compared with the experimental groups (p<0.05). Myeloperoxidase activity was higher in the experimental hepatopulmonary syndrome group than the other two groups (p<0.05). Surfactant protein A is present in experimental hepatopulmonary syndrome and leads to an imbalance between serum and pulmonary levels due to systemic inflammatory response.
ISSN:0102-8650
1678-2674
0102-8650
DOI:10.1590/S0102-8650201400150004