Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression

In a pragmatic trial involving older persons with treatment-resistant depression, augmentation of existing antidepressants with aripiprazole was better than augmentation with bupropion or a switch to bupropion.

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 388; no. 12; pp. 1067 - 1079
Main Authors:	Lenze, Eric J., Mulsant, Benoit H., Roose, Steven P., Lavretsky, Helen, Reynolds, Charles F., Blumberger, Daniel M., Brown, Patrick J., Cristancho, Pilar, Flint, Alastair J., Gebara, Marie A., Gettinger, Torie R., Lenard, Emily, Miller, J. Philip, Nicol, Ginger E., Oughli, Hanadi A., Pham, Vy T., Rollman, Bruce L., Yang, Lei, Karp, Jordan F.
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 23-03-2023
Subjects:	Aged Aging Aging General Antidepressants Antidepressive Agents - adverse effects Antidepressive Agents - therapeutic use Aripiprazole Aripiprazole - adverse effects Aripiprazole - therapeutic use Bupropion Bupropion - adverse effects Bupropion - therapeutic use Clinical Medicine Clinical Medicine General Depression Design Drug dosages Drug Therapy, Combination Geriatric psychiatry Geriatrics Humans Lithium Lithium Compounds - adverse effects Lithium Compounds - therapeutic use Mental depression Neurology Neurosurgery Neurosurgery General Nortriptyline - adverse effects Nortriptyline - therapeutic use Older people Patient-centered care Patients Primary care Psychiatry Remission Remission (Medicine) Treatment Switching
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Description
Summary:	In a pragmatic trial involving older persons with treatment-resistant depression, augmentation of existing antidepressants with aripiprazole was better than augmentation with bupropion or a switch to bupropion.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2204462