Search Results - "Gearing, A"

Processing of tumour necrosis factor-α precursor by metalloproteinases by Gearing, A. J. H, Beckett, P, Christodoulou, M, Churchill, M, Clements, J, Davidson, A. H, Drummond, A. H, Galloway, W. A, Gilbert, R, Gordon, J. L, Leber, T. M, Mangan, M, Miller, K, Nayee, P, Owen, K, Patel, S, Thomas, W, Wells, G, Wood, L. M, Woolley, K

“…Tumour necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory and immunomodulatory cytokine implicated in inflammatory conditions such as rheumatoid…”
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The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis by Davies, M J, Gordon, J L, Gearing, A J, Pigott, R, Woolf, N, Katz, D, Kyriakopoulos, A

“…The expression of PECAM, ICAM-1, VCAM-1, and E-selectin was studied in 64 samples of human coronary arteries taken from 15 explanted hearts obtained within 5…”
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Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis : A longitudinal clinical and MRI study by LEE, M. A, PALACE, J, STABLER, G, FORD, J, GEARING, A, MILLER, K

“…Metalloproteinases have been implicated in the pathogenesis of multiple sclerosis. We report longitudinal serum levels of gelatinase B and of the tissue…”
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Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells by Pigott, R, Dillon, L P, Hemingway, I H, Gearing, A J

“…Soluble forms of the adhesion molecules ICAM-1, VCAM-1 and E-selectin have been detected in supernatants from cytokine activated cultured endothelial cells…”
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Characterisation of matrix metalloproteinases and the effects of a broad-spectrum inhibitor (BB-1101) in peripheral nerve regeneration by Demestre, M, Wells, G.M, Miller, K.M, Smith, K.J, Hughes, R.A.C, Gearing, A.J, Gregson, N.A

“…The effect of treatment with a broad-spectrum inhibitor (BB1101) of the matrix metalloproteinases (MMPs) on nerve regeneration and functional recovery after…”
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Matrix metalloproteinases MMP-9 and MMP-7 are expressed in experimental autoimmune neuritis and the Guillain-Barré syndrome by Kieseier, B C, Clements, J M, Pischel, H B, Wells, G M, Miller, K, Gearing, A J, Hartung, H P

“…Matrix metalloproteinases (MMPs) are a family of enzymes that may be implicated in the pathogenesis of inflammatory demyelinating disorders such as multiple…”
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Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies by BANKS, R. E, GEARING, A. J. H, HEMINGWAY, I. K, NORFOLK, D. R, PERREN, T. J, SELBY, P. J

“…Cellular adhesion molecules have been implicated in tumour progression and metastasis. This study examines for the first time the serum concentrations of…”
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Characterization of matrix metalloproteinases in denervated muscle by Demestre, M., Orth, M., Wells, G. M., Gearing, A. J., Hughes, R. A. C., Gregson, N. A.

“…In a nerve crush model of denervation, we examined muscle matrix metalloproteinase (MMP) expression, localization and activity. In normal muscle, MMP mRNA…”
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Matrix metalloproteinase expression during experimental autoimmune neuritis by HUGHES, P. M, WELLS, G. M. A, CLEMENTS, J. M, GEARING, A. J. H, REDFORD, E. J, DAVIES, M, SMITH, K. J, HUGHES, R. A. C, BROWN, M. C, MILLER, K. M

“…Experimental autoimmune neuritis (EAN) is an animal model of Guillain-Barré syndrome. We have shown recently that BB-1101, a broad-spectrum matrix…”
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Matrix metalloproteinases and processing of pro-TNF-alpha by Gearing, A J, Beckett, P, Christodoulou, M, Churchill, M, Clements, J M, Crimmin, M, Davidson, A H, Drummond, A H, Galloway, W A, Gilbert, R

“…Tumor necrosis factor-alpha (TNF-alpha) is released from a cell membrane-anchored precursor by proteolytic cleavage. We have shown that broad spectrum…”
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Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview by Chandler, S, Miller, K.M, Clements, J.M, Lury, J, Corkill, D, Anthony, D.C.C, Adams, S.E, Gearing, A.J.H

“…The matrix metalloproteinases (MMPs) are a family of at least 14 zinc-dependent enzymes which are known to degrade the protein components of extracellular…”
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Adhesion molecules in inflammatory bowel disease by Jones, S C, Banks, R E, Haidar, A, Gearing, A J, Hemingway, I K, Ibbotson, S H, Dixon, M F, Axon, A T

“…The ability of leucocytes to adhere to endothelium is essential for leucocyte migration into inflammatory sites. Some of these adhesion molecules are released…”
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Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis by KIESEIER, B. C, KIEFER, R, CLEMENTS, J. M, MILLER, K, WELLS, G. M. A, SCHWEITZER, T, GEARING, A. J. H, HARTUNG, H.-P

“…Matrix metalloproteinases (MMPs) comprise a group of proteolytic enzymes that are implicated in the pathogenesis of inflammatory diseases of the nervous system…”
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Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS by Anthony, D.C, Miller, K.M, Fearn, S, Townsend, M.J, Opdenakker, G, Wells, G.M.A, Clements, J.M, Chandler, S, Gearing, A.J.H, Perry, V.H

“…In an experimentally-induced DTH model of MS, we examined mRNA and protein expression of a range of MMPs and of TNF α to establish the contribution that…”
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Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFα inhibitor in SCID mice with HIV-1 encephalitis by Persidsky, Y., Limoges, J., Rasmussen, J., Zheng, J., Gearing, A., Gendelman, H.E.

“…The effects of anti-inflammatory drugs on glial immunity and neuropathology were determined in a severe combined immune deficiency (SCID) mouse model of HIV-1…”
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Increased circulating adhesion molecule concentrations in patients with the systemic inflammatory response syndrome: a prospective cohort study by Cowley, H C, Heney, D, Gearing, A J, Hemingway, I, Webster, N R

“…To investigate the relationship between the soluble derivatives of endothelial adhesion molecules liberated by activated vascular endothelium and the…”
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A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-α processing attenuates experimental autoimmune neuritis by REDFORD, E. J, SMITH, K. J, GREGSON, N. A, DAVIES, M, HUGHES, P, GEARING, A. J. H, MILLER, K, HUGHES, R. A. C

“…Matrix metalloproteinases (MMPs) and the cytokine tumour necrosis factor (TNF)-alpha are implicated in the pathology of inflammatory demyelinating diseases of…”
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Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors by Liedtke, W, Cannella, B, Mazzaccaro, R J, Clements, J M, Miller, K M, Wucherpfennig, K W, Gearing, A J, Raine, C S

“…The proinflammatory Th1 cytokine, tumor necrosis factor-alpha (TNF alpha), the cell death signaling molecule FasL, and several extracellular matrix degrading…”
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Differential expression of matrix metalloproteinases in bacterial meningitis by Kieseier, Bernd C., Paul, Robert, Koedel, Uwe, Seifert, Thomas, Clements, John M., Gearing, Andrew J. H., Pfister, Hans-Walter, Hartung, Hans-Peter

“…Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of various inflammatory diseases of the central nervous system. Evidence is accumulating…”
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Identification of MMP-18, a Putative Novel Human Matrix Metalloproteinase by Cossins, J., Dudgeon, T.J., Catlin, G., Gearing, A.J.H., Clements, J.M.

“…A partial cDNA encoding the 3′ end of a putative novel human matrix metalloproteinase (MMP) was identified by sequence similarity searching of databases…”
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