Search Results - "Gear, R W"

Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain by Ferrari, L.F, Bogen, O, Alessandri-Haber, N, Levine, E, Gear, R.W, Levine, J.D

“…Highlights ► Attenuation of GRK2 enhances inflammatory mediator-induced hyperalgesia. ► The enhanced nociceptor function persists after recovery of GRK2…”
Get full text

NOP receptor mediates anti-analgesia induced by agonist–antagonist opioids by Gear, R.W, Bogen, O, Ferrari, L.F, Green, P.G, Levine, J.D

“…Highlights • In male rats, κ-opioids produce analgesia, followed by anti-analgesia. • Low-dose naloxone blocked anti-analgesia but not analgesia. •…”
Get full text

Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican by Bogen, O, Dina, O.A, Gear, R.W, Levine, J.D

“…Abstract The type 1 chemokine monocyte chemoattractant protein (MCP-1) has been implicated in the generation of inflammatory and neuropathic pain, but the…”
Get full text

Activation of Gi induces mechanical hyperalgesia poststress or inflammation by Dina, O.A, Khasar, S.G, Gear, R.W, Levine, J.D

“…Abstract In studies of the role of primary afferent nociceptor plasticity in the transition from acute to chronic pain we recently reported that exposure to…”
Get full text

The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain by Gear, R W, Miaskowski, C, Gordon, N C, Paul, S M, Heller, P H, Levine, J D

“…Nalbuphine, pentazocine, and butorphanol, mixed agonist/antagonist opioids that induce analgesia by acting predominantly at kappa opioid receptors, have…”
Get more information

Mechanical stimulation enhances endothelin-1 hyperalgesia by Joseph, E.K, Gear, R.W, Levine, J.D

“…Abstract When comparing a cumulative dose–response curve for endothelin-1 (ET-1)-induced mechanical hyperalgesia to the effect of individual doses (1 ng, 10…”
Get full text

Severity of alcohol-induced painful peripheral neuropathy in female rats: Role of estrogen and protein kinase (A and Cε) by Dina, O.A, Gear, R.W, Messing, R.O, Levine, J.D

“…Abstract Small-fiber painful peripheral neuropathy, a complication of chronic ethanol ingestion, is more severe in women. In the present study, we have…”
Get full text

Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens by Schmidt, B.L, Tambeli, C.H, Gear, R.W, Levine, J.D

“…The nucleus accumbens, as part of the mesolimbic dopaminergic reward pathway, mediates both addiction to and withdrawal from substances of abuse. In addition,…”
Get full text

Altered temporal pattern of evoked afferent activity in a rat model of vincristine-induced painful peripheral neuropathy by TANNER, K. D, REICHLING, D. B, GEAR, R. W, PAUL, S. M, LEVINE, J. D

“…It is known that the level of activity in nociceptive primary afferent nerve fibers increases in neuropathic conditions that produce pain, but changes in the…”
Get full text

Sex Differences in Masticatory Muscle Pain after Chewing by Karibe, H., Goddard, G., Gear, R.W.

“…Neither the etiology of muscle-related temporomandibular disorders (TMD) nor the reason for the disproportionate number of women suffering from these disorders…”
Get full text

Contribution of spinal inhibitory receptors in heterosegmental antinociception induced by noxious stimulation by Tambeli, C. H., Quang, P., Levine, J. D., Gear, R. W.

“…Noxious (i.e. painful) stimulation in the rat induces profound heterosegmental antinociception as demonstrated by the ability of either thermal stimulation (50…”
Get full text

Kappa-opioids produce significantly greater analgesia in women than in men by Gear, Robert W, Miaskowski, Christine, Gordon, Newton C, Paul, Steven M, Heller, Philip H, Levine, Jon D

“…Sex differences in human responses to nociceptive stimuli and painful pathological conditions have generally indicated that women report higher pain levels or…”
Get full text

Gender difference in analgesic response to the kappa-opioid pentazocine by Gear, Robert W., Gordon, Newton C., Heller, Philip H., Paul, Steven, Miaskowski, Christine, Levine, Jon D.

“…Gender difference in analgesia produced by the κ-opiate pentazocine was investigated in a model of post-operative dental pain. In a recent study [Gordon et…”
Get full text

Enhancement of morphine analgesia by the GABAB agonist baclofen by GORDON, N. C, GEAR, R. W, HELLER, P. H, PAUL, S, MIASKOWSKI, C, LEVINE, J. D

“…Opioid-GABAergic interactions for the treatment of post-operative pain were investigated in two double-blind, placebo-controlled experiments. We first studied…”
Get full text

Benzodiazepine mediated antagonism of opioid analgesia by Gear, R W, Miaskowski, C, Heller, P H, Paul, S M, Gordon, N C, Levine, J D

“…Activation of supraspinal gamma-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the…”
Get more information

Pain-Induced Analgesia Mediated by Mesolimbic Reward Circuits by Gear, Robert W, Aley, K. O, Levine, Jon D

“…We tested the hypothesis that noxious stimuli induce pain modulation by activation of supraspinal structures. We found that intense noxious stimuli (i.e.,…”
Get full text

Altered Nucleus Accumbens Circuitry Mediates Pain-Induced Antinociception in Morphine-Tolerant Rats by Schmidt, Brian L, Tambeli, Claudia H, Barletta, Justine, Luo, Lei, Green, Paul, Levine, Jon D, Gear, Robert W

“…We investigated the effect of chronic administration of morphine on noxious stimulus-induced antinociception (NSIA) produced by intraplantar capsaicin…”
Get full text

Interactions between fluoxetine and opiate analgesia for postoperative dental pain by Gordon, Newton C, Heller, Philip H, Gear, Robert W, Levine, Jon D

“…In a double-blind placebo-controlled study we investigated the analgesic efficacy of combinations of the serotonergic tricyclic antidepressant fluoxetine with…”
Get more information

Antinociception produced by an ascending spino-supraspinal pathway by Gear, RW, Levine, JD

“…Studies in mice and rats have shown that antinociception produced by intrathecal (i.t.) administration of opioids can be partially inhibited by…”
Get full text

Temporal factors in the enhancement of morphine analgesia by desipramine by Gordon, Newton C, Heller, Philip H, Gear, Robert W, Levine, Jon D

“…Administration of desipramine, the tricyclic noradrenergic agent, for 7 days pre-operatively, had been found to potentiate postoperative morphine analgesia. In…”
Get more information