The interaction analysis between advanced age and longer dialysis vintage on the survival of patients receiving maintenance hemodialysis

Objective To compare the all-cause mortality of aged and younger patients undergoing maintenance hemodialysis (MHD) over the long or short term, and to identify independent risk factors. Methods We performed a retrospective cohort study using the medical records of 181 patients undergoing MHD. We co...

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Bibliographic Details
Published in:	Journal of international medical research Vol. 50; no. 4; p. 3000605221088557
Main Authors:	Wu, Yong, Huang, Bihong, Zhang, Weichen, Farhan, Khawlah Ali Ahmed, Ge, Siyao, Wang, Mengjing, Zhang, Qian, Zhang, Minmin
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-04-2022 Sage Publications Ltd SAGE Publishing
Subjects:	Aged Diabetic nephropathy Glomerulonephritis Hemodialysis Humans Hypertension Hypertension, Renal Kidney Failure, Chronic - therapy Mortality Nephritis Renal Dialysis - adverse effects Retrospective Clinical Research Report Retrospective Studies Risk Factors advanced age Maintenance hemodialysis chronic glomerulonephritis all-cause mortality survival nephropathy duration of dialysis
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Summary:	Objective To compare the all-cause mortality of aged and younger patients undergoing maintenance hemodialysis (MHD) over the long or short term, and to identify independent risk factors. Methods We performed a retrospective cohort study using the medical records of 181 patients undergoing MHD. We compared the clinical characteristics and laboratory data of survivors and participants who died, according to their age and the duration of MHD. Binary stepwise logistic regression was used to identify independent risk factors for all-cause mortality. Results Cardiovascular and cerebrovascular diseases were the principal causes of mortality. The number of aged participants with hypertensive nephropathy as their primary kidney disease was significantly higher than the number of younger participants. The proportion with chronic glomerulonephritis was significantly higher for participants undergoing long-term MHD. Logistic regression analysis revealed that low body mass index, single-pool Kt/V, serum albumin, platelet count, and total iron-binding capacity; and high intact parathyroid hormone and N terminal pro B type natriuretic peptide were independent risk factors for all-cause mortality. Conclusions Aged patients are more susceptible to hypertensive nephropathy than younger patients. In addition, the survival of patients with chronic glomerulonephritis undergoing MHD is superior to that of those with hypertensive or diabetic nephropathy.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work.
ISSN:	0300-0605 1473-2300
DOI:	10.1177/03000605221088557