Search Results - "Ge, Maolin"

Modulating proteasome inhibitor tolerance in multiple myeloma: an alternative strategy to reverse inevitable resistance by Ge, Maolin, Qiao, Zhi, Kong, Yan, Liang, Hongyu, Sun, Yan, Lu, Hui, Xu, Zhenshu, Liu, Han

“…Background Resistance to proteasome inhibitors (PIs) is a major obstacle to the successful treatment of multiple myeloma (MM). Many mechanisms have been…”
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Exosomes mediate intercellular transfer of non–autonomous tolerance to proteasome inhibitors in mixed‐lineage leukemia by Ge, Maolin, Qiao, Zhi, Kong, Yan, Lu, Hui, Liu, Han

“…Proteasome inhibitors significantly improve cancer outcomes, but their use is eventually followed by proteasome inhibitor resistance and relapse. Current…”
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Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia by Zhu, Shouhai, Cheng, Xiaoyan, Wang, Ruiheng, Tan, Yuting, Ge, Maolin, Li, Dan, Xu, Qiongyu, Sun, Yan, Zhao, Chunjun, Chen, Saijuan, Liu, Han

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Restoring MLL reactivates latent tumor suppression-mediated vulnerability to proteasome inhibitors by Ge, Maolin, Li, Dan, Qiao, Zhi, Sun, Yan, Kang, Ting, Zhu, Shouhai, Wang, Shifen, Xiao, Hua, Zhao, Chunjun, Shen, Shuhong, Xu, Zhenshu, Liu, Han

“…MLL undergoes multiple distinct chromosomal translocations to yield aggressive leukemia with dismal outcomes. Besides their well-established role in…”
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Deubiquitinating enzyme inhibitor alleviates cyclin A1‐mediated proteasome inhibitor tolerance in mixed‐lineage leukemia by Ge, Maolin, Xu, Qiongyu, Kang, Ting, Li, Dan, Wang, Ruiheng, Chen, Zhihong, Xie, Shufeng, Wang, Wenbin, Liu, Han

“…Drug resistance is a significant obstacle to effective cancer treatment. Drug resistance develops from initially reversible drug‐tolerant cancer cells, which…”
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HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection by Luo, Zhen, Ge, Maolin, Chen, Junbo, Geng, Qibin, Tian, Mingfu, Qiao, Zhi, Bai, Lan, Zhang, Qi, Zhu, Chengliang, Xiong, Ying, Wu, Kailang, Liu, Fang, Liu, Yingle, Wu, Jianguo

“…Enterovirus 71 (EV71) is an RNA virus that causes hand-foot-mouth disease (HFMD), and even fatal encephalitis in children. Although EV71 pathogenesis remains…”
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Arsenic sulfide induces RAG1-dependent DNA damage for cell killing by inhibiting NFATc3 in gastric cancer cells by Kang, Ting, Ge, Maolin, Wang, Ruiheng, Tan, Zhen, Zhang, Xiuli, Zhu, Chuanying, Liu, Han, Chen, Siyu

“…Arsenic sulfide was found to have potential anti-cancer activities, especially in gastric cancer. However, the underlying mechanism need to be further…”
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HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress by Ge, Maolin, Luo, Zhen, Qiao, Zhi, Zhou, Yao, Cheng, Xin, Geng, Qibin, Cai, Yanyan, Wan, Pin, Xiong, Ying, Liu, Fang, Wu, Kailang, Liu, Yingle, Wu, Jianguo

“…Host innate immunity is crucial for cellular responses against viral infection sensed by distinct pattern recognition receptors and endoplasmic reticulum (ER)…”
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Integrative Analysis of Membrane Proteome and MicroRNA Reveals Novel Lung Cancer Metastasis Biomarkers by Kong, Yan, Qiao, Zhi, Ren, Yongyong, Genchev, Georgi Z., Ge, Maolin, Xiao, Hua, Zhao, Hongyu, Lu, Hui

“…Lung cancer is one of the most common human cancers both in incidence and mortality, with prognosis particularly poor in metastatic cases. Metastasis in lung…”
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Sequential expression of cyclooxygenase-2, glutamate receptor-2, and platelet activating factor receptor in rat hippocampal neurons after fluid percussion injury by Li, Zhiqiang, Shu, Qingming, Li, Lingzhi, Ge, Maolin, Zhang, Yongliang

“…Traumatic brain injury causes gene expression changes in different brain regions. Occurrence and development of traumatic brain injury are closely related,…”
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Reductive stress in cancer: coming out of the shadows by Ge, Maolin, Papagiannakopoulos, Thales, Bar-Peled, Liron

“…Redox imbalance is defined by disruption in oxidative and reductive pathways and has a central role in cancer initiation, development, and treatment. Although…”
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Cancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway[S] by Qiao, Zhi, Zhang, Yan, Ge, Maolin, Liu, Sha, Jiang, Xiaoteng, Shang, Zhi, Liu, Han, Cao, Chengxi, Xiao, Hua

“…We found that highly metastatic lung cancer cell derived sEVs can regulate the phenotype of recipient cells. With the help of quantitative proteomics, cancer…”
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NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer by Weiss-Sadan, Tommy, Ge, Maolin, Hayashi, Makiko, Gohar, Magdy, Yao, Cong-Hui, de Groot, Adriaan, Harry, Stefan, Carlin, Alexander, Fischer, Hannah, Shi, Lei, Wei, Ting-Yu, Adelmann, Charles H., Wolf, Konstantin, Vornbäumen, Tristan, Dürr, Benedikt R., Takahashi, Mariko, Richter, Marianne, Zhang, Junbing, Yang, Tzu-Yi, Vijay, Vindhya, Fisher, David E., Hata, Aaron N., Haigis, Marcia C., Mostoslavsky, Raul, Bardeesy, Nabeel, Papagiannakopoulos, Thales, Bar-Peled, Liron

“…Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through mutation of its negative regulator, KEAP1. NRF2 has been studied…”
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mTORC1‐mediated amino acid signaling is critical for cell fate determination under transplant‐induced stress by Cheng, Xiaoyan, Ge, Maolin, Zhu, Shouhai, Li, Dan, Wang, Ruiheng, Xu, Qiongyu, Chen, Zhihong, Xie, Shufeng, Liu, Han

“…Transplantation of in vitro‐manipulated cells is widely used in hematology. While transplantation is well recognized to impose severe stress on transplanted…”
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Diminished interaction between mutant NOTCH1 and the NuRD corepressor complex upregulates CCL17 in chronic lymphocytic leukemia by Wang, Shifen, Ge, Maolin, Cui, Jing, Qiao, Zhi, Chen, Xiuli, Wu, Shunquan, Zhan, Rong, Zhou, Huarong, Liu, Han, Xu, Zhenshu

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Abstract 6265: Combining arsenic and topoisomerase inhibitors synergistically inhibit gastric cancer by Kang, Ting, Ge, Maolin, Lu, Shumin, Wang, Qing, Zhu, Shouhai, Zhu, Chuanying, Zheng, Leizhen, Liu, Han, Chen, Siyu

“…Abstract Objectives: Arsenic compounds have cytotoxic activities in gastric cancer cells, however, the underlying mechanism is unclear and the clinical…”
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A T-cell independent universal cellular therapy strategy through antigen depletion by Li, Dan, Wang, Wenbing, Xie, Shufeng, Ge, Maolin, Wang, Ruiheng, Xu, Qiongyu, Sun, Yan, Zhu, Jiang, Liu, Han

“…T cell therapeutic strategy using CD19-targeting chimeric antigen receptor (CAR) is a revolutionary, novel, and successful treatment for B-cell malignancies…”
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DrugMap: A quantitative pan-cancer analysis of cysteine ligandability by Takahashi, Mariko, Chong, Harrison B, Zhang, Siwen, Yang, Tzu-Yi, Lazarov, Matthew J, Harry, Stefan, Maynard, Michelle, Hilbert, Brendan, White, Ryan D, Murrey, Heather E, Tsou, Chih-Chiang, Vordermark, Kira, Assaad, Jonathan, Gohar, Magdy, Dürr, Benedikt R, Richter, Marianne, Patel, Himani, Kryukov, Gregory, Brooijmans, Natasja, Alghali, Aliyu Sidi Omar, Rubio, Karla, Villanueva, Antonio, Zhang, Junbing, Ge, Maolin, Makram, Farah, Griesshaber, Hanna, Harrison, Drew, Koglin, Ann-Sophie, Ojeda, Samuel, Karakyriakou, Barbara, Healy, Alexander, Popoola, George, Rachmin, Inbal, Khandelwal, Neha, Neil, Jason R, Tien, Pei-Chieh, Chen, Nicholas, Hosp, Tobias, van den Ouweland, Sanne, Hara, Toshiro, Bussema, Lillian, Dong, Rui, Shi, Lei, Rasmussen, Martin Q, Domingues, Ana Carolina, Lawless, Aleigha, Fang, Jacy, Yoda, Satoshi, Nguyen, Linh Phuong, Reeves, Sarah Marie, Wakefield, Farrah Nicole, Acker, Adam, Clark, Sarah Elizabeth, Dubash, Taronish, Kastanos, John, Oh, Eugene, Fisher, David E, Maheswaran, Shyamala, Haber, Daniel A, Boland, Genevieve M, Sade-Feldman, Moshe, Jenkins, Russell W, Hata, Aaron N, Bardeesy, Nabeel M, Suvà, Mario L, Martin, Brent R, Liau, Brian B, Ott, Christopher J, Rivera, Miguel N, Lawrence, Michael S, Bar-Peled, Liron

“…Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors for a wide range of targets in cancer. However,…”
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NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer by Weiss-Sadan, Tommy, Ge, Maolin, Hayashi, Makiko, Gohar, Magdy, Yao, Cong-Hui, de Groot, Adriaan, Harry, Stefan, Carlin, Alexander, Fischer, Hannah, Shi, Lei, Wei, Ting-Yu, Adelmann, Charles H., Wolf, Konstantin, Vornbäumen, Tristan, Dürr, Benedikt R., Takahashi, Mariko, Richter, Marianne, Zhang, Junbing, Yang, Tzu-Yi, Vijay, Vindhya, Fisher, David E., Hata, Aaron N., Haigis, Marcia C., Mostoslavsky, Raul, Bardeesy, Nabeel, Papagiannakopoulos, Thales, Bar-Peled, Liron

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Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication by Bai, Lan, Zhang, Wei, Tan, Li, Yang, Hongchuan, Ge, Maolin, Zhu, Chengliang, Zhang, Rui, Cao, Yanhua, Chen, Junbo, Luo, Zhen, Ho, Wenzhe, Liu, Fang, Wu, Kailang, Wu, Jianguo

“…Hepatitis B virus (HBV) infection causes acute and chronic liver diseases, but is not directly cytopathic. Liver injury results from repeated attempts of the…”
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