Search Results - "Gbotosho, Grace O."

Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling by Aroonsri, Aiyada, Akinola, Olugbenga, Posayapisit, Navaporn, Songsungthong, Warangkhana, Uthaipibull, Chairat, Kamchonwongpaisan, Sumalee, Gbotosho, Grace O., Yuthavong, Yongyuth, Shaw, Philip J.

“…[Display omitted] •The glmS ribozyme tool is functional in Plasmodium berghei.•Dihydrofolate reductase-thymidylate synthase (DHFR-TS) attenuated parasites are…”
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Factors contributing to anaemia after uncomplicated falciparum malaria in under five year-old Nigerian children ten years following adoption of artemisinin-based combination therapies as first-line antimalarials by Sowunmi, Akintunde, Fatunmbi, Bayo, Akano, Kazeem, Wewe, Olubunmi A, Agomo, Chimere, Finomo, Finomo, Ebenebe, Joy, Jiya, Nma, Ambe, Jose, Wammanda, Robinson, Ntadom, Godwin, Mokuolu, Olugbenga, Emechebe, George, Ezeigwe, Nnenna, Ayede, Adejumoke I, Adewoye, Elsie O, Gbotosho, Grace O, Folarin, Onikepe A, Happi, Christian T, Oguche, Stephen, Oyibo, Wellington A, Useh, Francis

“…Artemisinin-based combination therapies (ACTs) have remained efficacious treatments of acute falciparum malaria in many endemic areas but there is little…”
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Effectiveness of artemisinin-based combination therapy used in the context of home management of malaria: a report from three study sites in sub-Saharan Africa by Ajayi, Ikeoluwapo O, Browne, Edmund N, Bateganya, Fred, Yar, Denis, Happi, Christian, Falade, Catherine O, Gbotosho, Grace O, Yusuf, Bidemi, Boateng, Samuel, Mugittu, Kefas, Cousens, Simon, Nanyunja, Miriam, Pagnoni, Franco

“…The use of artemisinin-based combination therapy (ACT) at the community level has been advocated as a means to increase access to effective antimalarial…”
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Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children by Akano, Kazeem, Ntadom, Godwin, Agomo, Chimere, Happi, Christian T, Folarin, Onikepe A, Gbotosho, Grace O, Mokuolu, Olugbenga, Finomo, Finomo, Ebenebe, Joy C, Jiya, Nma, Ambe, Jose, Wammanda, Robinson, Emechebe, George, Basorun, Oluwabunmi K, Wewe, Olubunmi A, Amoo, Sikiru, Ezeigwe, Nnenna, Oguche, Stephen, Fatunmbi, Bayo, Sowunmi, Akintunde

“…In acute falciparum malaria, asexual parasite reduction ratio two days post-treatment initiation (PRRD2) ≥ 10 000 per cycle has been used as a measure of the…”
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Activities of Amodiaquine, Artesunate, and Artesunate-Amodiaquine against Asexual- and Sexual-Stage Parasites in Falciparum Malaria in Children by SOWUNMI, Akintunde, BALOGUN, Tunde, GBOTOSHO, Grace O, HAPPI, Christian T, ADEDEJI, Ahmed A, FEHINTOLA, Fatai A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Clinical illness and outcomes in Nigerian children with persistent early-appearing anaemia following initiation of artemisinin-based combination treatments of uncomplicated falciparum malaria by Akano, Kazeem, Fatunmbi, Bayo, Ntadom, Godwin, Ayede, Adejumoke I, Aderoyeje, Temitope, Bakre, Adewale, Alebiosu, Omobolaji T, Akpoborie, Odafe, Okafor, Chukwuebuka, Gbotosho, Grace O, Folarin, Onikepe A, Ebenebe, Joy C, Ambe, Jose, Wammanda, Robinson, Jiya, Nma, Finomo, Finomo, Emechebe, George, Mokuolu, Olugbenga, Agomo, Chimere, Oguche, Stephen, Happi, Christian, Sowunmi, Akintunde

“…In non-anaemic children with malaria, early-appearing anaemia (EAA) is common following artemisinin-based combination treatments (ACTs) and it may become…”
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Potential contribution of prescription practices to the emergence and spread of chloroquine resistance in south-west Nigeria: caution in the use of artemisinin combination therapy by Gbotosho, Grace O, Happi, Christian T, Ganiyu, Abideen, Ogundahunsi, Olumide A, Sowunmi, Akin, Oduola, Ayoade M

“…Prescription practices have been shown to influence the emergence of anti-malarial drug resistance. Thus efforts in this study were devoted to evaluating the…”
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A high performance liquid chromatographic assay of mefloquine in saliva after a single oral dose in healthy adult Africans by Gbotosho, Grace O, Happi, Christian T, Lawal, Omowunmi, Sijuade, Abayomi, Sowunmi, Akin, Oduola, Ayoade

“…Mefloquine-artesunate is a formulation of artemisinin based combination therapy (ACT) recommended by the World Health Organization and historically the first…”
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Comparative efficacy of sulphadoxine-pyrimethamine and dihydroartemisinin-piperaquine against malaria infection during late-stage pregnancy in mice by Akinola, Olugbenga, Ategbero, Elizabeth, Amusan, Abiodun I., Gbotosho, Grace O.

“…The introduction of artemisinin combination therapies (ACTs) against malaria infections opened up a window of possibilities to combat malaria in pregnancy…”
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Risk factors for Plasmodium falciparum hyperparasitaemia in malarious children by Sowunmi, Akintunde, Okuboyejo, Titilope M, Gbotosho, Grace O, Happi, Christian T

“…Hyperparasitaemia is a feature of childhood severe malaria but there is little information on the risk factors for hyperparasitaemia in malarious children The…”
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Early variations in plasmodium falciparum dynamics in Nigerian children after treatment with two artemisinin-based combinations: implications on delayed parasite clearance by Michael, Obaro S, Gbotosho, Grace O, Folarin, Onikepe A, Okuboyejo, Titilope, Sowunmi, Akintunde, Oduola, Ayoade M J, Happi, Christian T

“…Combination treatments, preferably containing an artemisinin derivative, are recommended to improve efficacy and prevent Plasmodium falciparum drug resistance…”
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Plasmodium falciparum gametocyte sex ratios in children with acute, symptomatic, uncomplicated infections treated with amodiaquine by Sowunmi, Akintunde, Balogun, Sulayman T, Gbotosho, Grace O, Happi, Christian T

“…Amodiaquine is frequently used as a partner drug in combination therapy or in some setting as monotherapy, but little is known about its effects on gametocyte…”
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Population structure of Plasmodium falciparum gametocyte sex ratios in malarious children in an endemic area by Sowunmi, Akintunde, Gbotosho, Grace O, Happi, Christian T, Folarin, Onikepe A, Balogun, Sulayman T

“…Abstract The gametocyte sex ratio (proportion of gametocytes that are male) of Plasmodium falciparum may influence transmission. The distribution of P…”
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World Antimalarial Resistance Network (WARN) IV: clinical pharmacology by Barnes, Karen I, Lindegardh, Niklas, Ogundahunsi, Olumide, Olliaro, Piero, Plowe, Christopher V, Randrianarivelojosia, Milijaona, Gbotosho, Grace O, Watkins, William M, Sibley, Carol H, White, Nicholas J

“…A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment of malaria, through informing current drug selection and use…”
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Comparison of SYBR Green I-, PicoGreen-, and [³H]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine by Abiodun, Oyindamola O, Gbotosho, Grace O, Ajaiyeoba, Edith O, Happi, Christian T, Hofer, Sandra, Wittlin, Sergio, Sowunmi, Akin, Brun, Reto, Oduola, Ayoade M. J

“…The standard method for in vitro antimalarial drug screening is based on the isotopic assay which is expensive and utilizes radioactive materials with limited…”
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Triple artemisinin-based combination therapy (TACT): Efficacy of dihydroartemisinin-piperaquine plus chloroquine against Plasmodium berghei ANKA strains with different drug sensitivities in a murine malaria model by Akinola, Olugbenga, Afolabi, Oluwapelumi O., Adebisi-Jose, Gbemisola O., Amusan, Abiodun I., Olumoh-Adbul, Hidayah A., Olabanji, Olawale, Teslim, Olayinka, Gbotosho, Grace O.

“…Evident detection of artemisinin resistance markers in patient isolates of Plasmodium falciparum from East Africa threatens the efficacy of artemisinin-based…”
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Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children by Sowunmi, Akintunde, Nkogho, Oluchi O, Okuboyejo, Titilope M, Gbotosho, Grace O, Happi, Christian T, Adewoye, Elsie O

“…The gametocyte sex ratio of Plasmodium falciparum, defined as the proportion of gametocytes that are male, may influence transmission but little is known of…”
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Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children before and after artemisinin-based combination treatments by Sowunmi, Akintunde, Okuboyejo, Titilope M, Gbotosho, Grace O, Happi, Christian T

“…Artemisinin-based combination treatments (ACTs) are the recommended first-line antimalarials globally, but their influence on the risk factors associated with…”
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A simple cost-effective high performance liquid chromatographic assay of sulphadoxine in whole blood spotted on filter paper for field studies by Gbotosho, Grace O, Happi, Christian T, Sijuade, Abayomi O, Sowunmi, Akin, Oduola, Ayoade M J

“…Artesunate plus sulphadoxine-pyrimethamine is one of the four artemisinin-based combination therapies currently recommended by WHO as first-line treatment for…”
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Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children by Sowunmi, Akintunde, Balogun, Sulayman T, Gbotosho, Grace O, Happi, Christian T

“…Characteristics of primary and recrudescent Plasmodium falciparum infections were evaluated in 25 children who did not recover after amodiaquine (AQ)…”
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