Search Results - "Gbotosho, G. O."

Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in Nigeria by Bankole, A. E., Adekunle, A. A., Sowemimo, A. A., Umebese, C. E, Abiodun, O, Gbotosho, G. O.

“…The use of plant to meet health-care needs has greatly increased worldwide in the recent times. The search for new plant-derived bioactive agents that can be…”
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Selection of Plasmodium falciparum Multidrug Resistance Gene 1 Alleles in Asexual Stages and Gametocytes by Artemether-Lumefantrine in Nigerian Children with Uncomplicated Falciparum Malaria by HAPPI, C. T, GBOTOSHO, G. O, FOLARIN, O. A, SOWUNMI, A, HUDSON, T, O'NEIL, M, MILHOUS, W, WIRTH, D. F, ODUOLA, A. M. J

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Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria by Happi, C T, Gbotosho, G O, Folarin, O A, Bolaji, O M, Sowunmi, A, Kyle, D E, Milhous, W, Wirth, D F, Oduola, A M J

“…This study investigated the association between Plasmodium falciparum chloroquine resistance transporter (pfcrt) T76 and P. falciparum multidrug resistance…”
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In vitro amodiaquine resistance and its association with mutations in pfcrt and pfmdr1 genes of Plasmodium falciparum isolates from Nigeria by Folarin, O.A., Bustamante, C., Gbotosho, G.O., Sowunmi, A., Zalis, M.G., Oduola, A.M.J., Happi, C.T.

“…This study demonstrates the role of Plasmodium falciparum mutations in phenotypic amodiaquine resistance in vitro and can be useful epidemiological tool for…”
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In Vitro and In Vivo Antimalarial Activity of Ficus thonningii Blume (Moraceae) and Lophira alata Banks (Ochnaceae), Identified from the Ethnomedicine of the Nigerian Middle Belt by Oduola, A. M. J., Happi, T. C., Ajaiyeoba, E. O., Gbotosho, G. O., Akinboye, D. O., Falade, M. O., Abiodun, O. O.

“…Drug resistance in Plasmodium falciparum requires that new drugs must be developed. Plants are a potential source for drug discovery and development. Two…”
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Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria by Happi, C T, Gbotosho, G O, Sowunmi, A, Falade, C O, Akinboye, D O, Gerena, L, Kyle, D E, Milhous, W, Wirth, D F, Oduola, A M J

“…Parasite genotyping by a polymerase chain reaction was used to distinguish recrudescent from newly acquired Plasmodium falciparum infections in 50 of 160…”
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Open randomized study of artesunate‐amodiaquine vs. chloroquine‐pyrimethamine‐sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in Nigerian children by Sowunmi, A., Fehintola, F. A., Adedeji, A. A., Gbotosho, G. O., Tambo, E., Fateye, B. A., Happi, T. C., Oduola, A. M. J.

“…Summary Background  Artemisinin‐based combination antimalarials are currently considered effective alternatives for the treatment of malaria in Africa, but…”
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Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine–pyrimethamine resistance in malaria-infected patients from Nigeria by Happi, C.T., Gbotosho, G.O., Folarin, O.A., Akinboye, D.O., Yusuf, B.O., Ebong, O.O., Sowunmi, A., Kyle, D.E., Milhous, W., Wirth, D.F., Oduola, A.M.J.

“…Mutations in Plasmodium falciparum dihydrofolate reductase ( dhfr) and dihydropteroate synthase ( dhps) genes have been used as means to predict treatment…”
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Cultural categorization of febrile illnesses in correlation with herbal remedies used for treatment in Southwestern Nigeria by Ajaiyeoba, E.O, Oladepo, O, Fawole, O.I, Bolaji, O.M, Akinboye, D.O, Ogundahunsi, O.A.T, Falade, C.O, Gbotosho, G.O, Itiola, O.A, Happi, T.C, Ebong, O.O, Ononiwu, I.M, Osowole, O.S, Oduola, O.O, Ashidi, J.S, Oduola, A.M.J

“…The ethnographic study was conducted in two communities in Oyo State in Southwestern Nigeria. The study sites consisted of a rural and an urban local…”
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Effects of antifolates - co-trimoxazole and pyrimethamine-sulfadoxine - on gametocytes in children with acute, symptomatic, uncomplicated, Plasmodium falciparum malaria by Sowunmi, A, Fateye, B A, Adedeji, A A, Fehintola, F A, Bamgboye, A E, Babalola, C P, Happi, T C, Gbotosho, G O

“…Antimalarial drugs including the antifolate, pyrimethamine-sulfadoxine (PS), can modulate the prevalence and intensities of gametocytaemia following treatment…”
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Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children by Sowunmi, A, Adedeji, A A, Gbotosho, G O, Fateye, B A, Happi, T C

“…The effects of pyrimethamine-sulphadoxine (PS), chloroquine plus chlorpheniramine, a H1 receptor antagonist that reverses chloroquine resistance in Plasmodium…”
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Open randomized study of pyrimethamine–sulphadoxine vs. pyrimethamine–sulphadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in children by Sowunmi, A., Fehintola, F. A., Adedeji, A. A., Gbotosho, G. O., Falade, C. O., Tambo, E., Fateye, B. A., Happi, T. C., Oduola, A. M. J.

“…Summary Background  Increasing drug resistance in Plasmodium falciparum has necessitated renewed search for cheap, effective alternatives to commonly available…”
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Herpes simplex labialis in children with acute falciparum malaria by Sowunmi, A., Gbotosho, G.O., Adedeji, A.A., Tambo, E., Bolaji, O.M., Happi, C.T., Fateye, B.A.

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Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria by HAPPI, C. T, GBOTOSHO, G. O, FOLARIN, O. A, SOWUNMI, A, BOLAJI, O. M, FATEYE, B. A, KYLE, D. E, MILHOUS, W, WIRTH, D. F, ODUOLA, A. M. J

“…Chloroquine (CQ) resistance in Plasmodium falciparum is associated with polymorphisms in loci on pfcrt and pfmdr1 genes. In this study, we determined the…”
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effects of artemether–lumefantrine vs amodiaquine–sulfalene–pyrimethamine on the hepatomegaly associated with Plasmodium falciparum malaria in children by SOWUNMI, A, GBOTOSHO, G. O, ADEDEJI, A. A, TAMBO, E, FATEYE, B. A, HAPPI, C. T, AMOO, A. O. J

“…An open randomized controlled study of artemether–lumefantrine (AL) and amodiaquine–sulfalene–pyrimethamine (ASP) for the treatment of uncomplicated Plasmodium…”
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Predictors of the failure of treatment with pyrimethamine–sulfadoxine in children with uncomplicated falciparum malaria by Sowunmi, A., Fateye, B.A., Adedeji, A.A., Gbotosho, G.O., Happi, T.C., Bamgboye, A.E., Bolaji, O.M., Oduola, A.M.J.

“…The prevalence of pyrimethamine–sulfadoxine (PS)-resistant Plasmodium falciparum malaria has been increasing in sub-Saharan Africa or other parts of the world…”
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Amodiaquine-Ciprofloxacin: a potential combination therapy against drug resistant malaria by Falajiki, Y F, Akinola, O, Abiodun, O O, Happi, C T, Sowunmi, A, Gbotosho, G O

“…Emergence of malaria parasites resistant to artemisinin necessitates the need for development of new antimalarial therapies. Ciprofloxacin (CFX) a second…”
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Enhanced efficacy of chloroquine-chlorpheniramine combination in acute uncomplicated falciparum malaria in children by Sowunmi, A., Oduola, A.M.J., Ogundahunsi, O.A.T., Falade, C.O., Gbotosho, G.O., Salako, L.A.

“…Chlorpheniramine, a histamine H 1 receptor antagonist, reverses chloroquine resistance in Plasmodium falciparum in vitro. However, the clinical significance of…”
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Plasmodium falciparum Malaria in Nigerian Children During High and Low Transmission Seasons: Gametocyte Carriage and Response to Oral Chloroquine by Adedeji, A. A., Fehintola, F. A., Fateye, B. A., Happi, T. C., Amoo, A. O. J., Gbotosho, G. O., Sowunmi, A.

“…Plasmodium falciparum malaria during high and low transmission seasons was evaluated in 1031 children treated with different antimalarial drug in a…”
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Gastrointestinal manifestations of acute falciparum malaria in children by SOWUNMI, A, OGUNDAHUNSI, O. A. T, FALADE, C. O, GBOTOSHO, G. O, ODUOLA, A. M. J

“…The gastrointestinal manifestations of acute symptomatic uncomplicated falciparum malaria were studied in 184 consecutive children aged from 6 months to 15…”
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