Search Results - "Gazzaniga, Francesca S."
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Symbionts exploit complex signaling to educate the immune system
Published in Proceedings of the National Academy of Sciences - PNAS (26-12-2019)“…The mammalian immune system is tolerized to trillions of microbes residing on bodily surfaces and can discriminate between symbionts and pathogens despite…”
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A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip
Published in Nature biomedical engineering (01-07-2019)“…The diverse bacterial populations that comprise the commensal microbiome of the human intestine play a central role in health and disease. A method that…”
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The Major Reverse Transcriptase―Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis
Published in Cancer research (Chicago, Ill.) (01-05-2013)“…Human telomerase reverse transcriptase (hTERT; the catalytic protein subunit of telomerase) is subjected to numerous alternative splicing events, but the…”
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Microbiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy
Published in Experimental & molecular medicine (01-09-2023)“…Our bodies are inhabited by trillions of microorganisms. The host immune system constantly interacts with the microbiota in barrier organs, including the…”
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An Investigation of the Effects of the Core Protein Telomerase Reverse Transcriptase on Wnt Signaling in Breast Cancer Cells
Published in Molecular and Cellular Biology (01-01-2014)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Harnessing Colon Chip Technology to Identify Commensal Bacteria That Promote Host Tolerance to Infection
Published in Frontiers in cellular and infection microbiology (12-03-2021)“…Commensal bacteria within the gut microbiome contribute to development of host tolerance to infection, however, identifying specific microbes responsible for…”
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Sharing the load in NAD metabolism
Published in Cell host & microbe (14-12-2022)“…Recently in Cell Metabolism, Challapa et al. used isotope labeling to track NAD metabolism in host tissues and the gut microbiota. They describe a symbiotic…”
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An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity
Published in Blood (11-12-2014)“…Telomerase is a ribonucleoprotein complex that adds telomeric DNA to the ends of linear chromosomes. It contains two core canonical components: the essential…”
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Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance
Published in Nature (London) (11-05-2023)“…The gut microbiota is a crucial regulator of anti-tumour immunity during immune checkpoint inhibitor therapy. Several bacteria that promote an anti-tumour…”
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Gut microbial fatty acid isomerization modulates intraepithelial T cells
Published in Nature (London) (27-07-2023)“…The human gut microbiome constantly converts natural products derived from the host and diet into numerous bioactive metabolites 1 – 3 . Dietary fats are…”
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Microbial transmission in the social microbiome and host health and disease
Published in Cell (04-01-2024)“…Although social interactions are known to drive pathogen transmission, the contributions of socially transmissible host-associated mutualists and commensals to…”
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Gut complement induced by the microbiota combats pathogens and spares commensals
Published in Cell (15-02-2024)“…Canonically, the complement system is known for its rapid response to remove microbes in the bloodstream. However, relatively little is known about a…”
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Establishment of a Modular Anaerobic Human Intestine Chip
Published in Methods in molecular biology (Clifton, N.J.) (2022)“…It is impossible to analyze human-specific host-microbiome interactions using animal models and existing in vitro methods fail to support survival of human…”
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Veggies and Intact Grains a Day Keep the Pathogens Away
Published in Cell (17-11-2016)“…In this issue of Cell, Desai et al. compare how dietary fiber affects the gut microbiota and susceptibility to disease. They find that a fiber-free diet…”
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Wild gut microbiota protects from disease
Published in Cell research (01-02-2018)“…Wild mice are genetically similar to laboratory mice, but have a distinct gut microbiota that protects from disease. There is no doubt that the trillions of…”
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Publisher Correction: Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance
Published in Nature (London) (22-06-2023)Get full text
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Heterogeneous dysregulation of microRNAs across the autism spectrum
Published in Neurogenetics (01-07-2008)“…microRNAs (miRNAs) are ~21 nt transcripts capable of regulating the expression of many mRNAs and are abundant in the brain. miRNAs have a role in several…”
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Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip
Published in Nature biomedical engineering (01-07-2019)“…In the version of this Article originally published, the authors mistakenly cited Fig. 5d in the sentence beginning ‘Importantly, the microbiome cultured in…”
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Publisher Correction: Targeting PD-L2–RGMb overcomes microbiomerelated immunotherapy resistance
Published in Nature (London) (22-06-2023)Get full text
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20
Abstract A58: Wnt signaling pathway components are associated with telomerase activity in breast cancer
Published in Cancer research (Chicago, Ill.) (15-09-2011)“…Abstract Telomerase is a ribonucleoprotein complex that adds TTAGGG repeats to telomeres in a highly regulated fashion. Telomerase activity is absent in normal…”
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