Search Results - "Gazda, Lawrence S"

MEF2 plays a significant role in the tumor inhibitory mechanism of encapsulated RENCA cells via EGF receptor signaling in target tumor cells by Martis, Prithy C, Dudley, Atira T, Bemrose, Melissa A, Gazda, Hunter L, Smith, Barry H, Gazda, Lawrence S

“…Agarose encapsulated murine renal adenocarcinoma cells (RENCA macrobeads) are currently being investigated in clinical trials as a treatment for…”
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Yield, cell composition, and function of islets isolated from different ages of neonatal pigs by Arefanian, Hossein, Ramji, Qahir, Gupta, Nancy, Spigelman, Aliya F, Grynoch, Donald, MacDonald, Patrick E, Mueller, Thomas F, Gazda, Lawrence S, Rajotte, Ray V, Rayat, Gina R

“…The yield, cell composition, and function of islets isolated from various ages of neonatal pigs were characterized using and experimental models. Islets from…”
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A comprehensive microbiological safety approach for agarose encapsulated porcine islets intended for clinical trials by Gazda, Lawrence S., Collins, James, Lovatt, Archie, Holdcraft, Robert W., Morin, Merribeth J., Galbraith, Daniel, Graham, Melanie, Laramore, Melissa A., Maclean, Christine, Black, John, Milne, Euan W., Marthaler, Douglas G., Vinerean, Horatiu V., Michalak, Michelle M., Hoffer, Deborah, Richter, Steven, Hall, Richard D., Smith, Barry H.

“…Background The use of porcine islets to replace insulin‐producing islet β‐cells, destroyed during the diabetogenic disease process, presents distinct…”
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Retention of gene expression in porcine islets after agarose encapsulation and long-term culture by Dumpala, Pradeep R., Holdcraft, Robert W., Martis, Prithy C., Laramore, Melissa A., Parker, Thomas S., Levine, Daniel M., Smith, Barry H., Gazda, Lawrence S.

“…Agarose encapsulation of porcine islets allows extended in vitro culture, providing ample time to determine the functional capacity of the islets and conduct…”
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A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats by Chacur, Marucia, Milligan, Erin D, Gazda, Lawrence S, Armstrong, Charles, Wang, Haichao, Tracey, Kevin J, Maier, Steven F, Watkins, Linda R

“…Immune activation near healthy peripheral nerves may have a greater role in creating pathological pain than previously recognized. We have developed a new…”
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First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 3: Porcine islet product manufacturing and release testing criteria by Rayat, Gina R., Gazda, Lawrence S., Hawthorne, Wayne J., Hering, Bernhard J., Hosking, Peter, Matsumoto, Shinichi, Rajotte, Ray V.

“…In the 2009 IXA consensus, the requirements for the quality and control of manufacturing of porcine islet products were based on the U.S. regulatory framework…”
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Enhancement of in vitro and in vivo function of agarose-encapsulated porcine islets by changes in the islet microenvironment by Holdcraft, Robert W, Gazda, Lawrence S, Circle, Lisa, Adkins, Hollie, Harbeck, Steven G, Meyer, Eric D, Bautista, Melissa A, Martis, Prithy C, Laramore, Melissa A, Vinerean, Horatiu V, Hall, Richard D, Smith, Barry H

“…The transplantation of porcine islets of Langerhans to treat type 1 diabetes may provide a solution to the demand for insulin-producing cells. Porcine islets…”
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Clinical laboratory and imaging evidence for effectiveness of agarose-agarose macrobeads containing stem-like cells derived from a mouse renal adenocarcinoma cell population (RMBs) in treatment-resistant, advanced metastatic colorectal cancer: Evaluation of a biological-systems approach to cancer therapy (U.S. FDA IND-BB 10091; NCT 02046174, NCT 01053013) by Smith, Barry H, Gazda, Lawrence S, Fahey, Thomas J, Nazarian, Angelica, Laramore, Melissa A, Martis, Prithy, Andrada, Zoe P, Thomas, Joanne, Parikh, Tapan, Sureshbabu, Sudipta, Berman, Nathaniel, Ocean, Allyson J, Hall, Richard D, Wolf, David J

“…The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based…”
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No Evidence of Viral Transmission following Long-Term Implantation of Agarose Encapsulated Porcine Islets in Diabetic Dogs by Carraway, Joseph W., Hall, Richard D., Laramore, Melissa A., Vinerean, Horatiu V., Gazda, Lawrence S., Smith, Barry H.

“…We have previously described the use of a double coated agarose-agarose porcine islet macrobead for the treatment of type I diabetes mellitus. In the current…”
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Encapsulation of porcine islets permits extended culture time and insulin independence in spontaneously diabetic BB rats by Gazda, Lawrence S, Vinerean, Horatiu V, Laramore, Melissa A, Diehl, Carolyn H, Hall, Richard D, Rubin, Albert L, Smith, Barry H

“…The ability to culture porcine islets for extended times allows for both their functional assessment and the assurance of their microbiological safety prior to…”
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Pravastatin Improves Glucose Regulation and Biocompatibility of Agarose Encapsulated Porcine Islets following Transplantation into Pancreatectomized Dogs by Carraway, Joseph W., Hall, Richard D., Laramore, Melissa A., Vinerean, Horatiu V., Gazda, Lawrence S., Smith, Barry H.

“…The encapsulation of porcine islets is an attractive methodology for the treatment of Type I diabetes. In the current study, the use of pravastatin as a mild…”
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First-in-Human Phase 1 Trial of Agarose Beads Containing Murine RENCA Cells in Advanced Solid Tumors by Smith, Barry H., Parikh, Tapan, Andrada, Zoe P., Fahey, Thomas J., Berman, Nathaniel, wiles, Madeline, Nazarian, Angelica, Thomas, Joanne, Arreglado, Anna, Akahoho, Eugene, wolf, David J., Levine, Daniel M., Parker, Thomas S., Gazda, Lawrence S., Ocean, Allyson J.

“…PURPOSE: Agarose macrobeads containing mouse renal adenocarcinoma cells (RMBs) release factors, suppressing the growth of cancer cells and prolonging survival…”
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Streptozotocin is responsible for the induction and progression of renal tumorigenesis in diabetic Wistar-Furth rats treated with insulin or transplanted with agarose encapsulated porcine islets by Vinerean, Horatiu V., Gazda, Lawrence S., Hall, Richard D., Smith, Barry H.

“…Streptozotocin (STZ), a nitrosourea with DNA alkylating properties, has been widely used to induce hyperglycemia by specifically destroying the…”
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Multiple clinically relevant immunotherapies prolong the function of microencapsulated porcine islet xenografts in diabetic NOD mice without the use of anti‐CD154 mAb by Safley, Susan A., Barber, Graham F., Holdcraft, Robert W., Gazda, Lawrence S., Duncanson, Stephanie, Poznansky, Mark C., Sambanis, Athanassios, Weber, Collin J.

“…Background Our goal was to identify clinically relevant immunotherapies that synergize with microencapsulation to protect adult porcine islet (API) xenografts…”
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Long‐term efficacy and safety of porcine islet macrobeads in nonimmunosuppressed diabetic cynomolgus macaques by Holdcraft, Robert W., Graham, Melanie J., Bemrose, Melissa A., Mutch, Lucas A., Martis, Prithy C., Janecek, Jody L., Hall, Richard D., Smith, Barry H., Gazda, Lawrence S.

“…Although human islet transplantation has proven to provide clinical benefits, especially the near complete amelioration of hypoglycemia, the supply of human…”
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Improved glucose regulation on a low carbohydrate diet in diabetic rats transplanted with macroencapsulated porcine islets by Vinerean, Horatiu V, Gazda, Lawrence S, Hall, Richard D, Rubin, Albert L, Smith, Barry H

“…Islet xenografts from porcine donors can reverse diabetes in experimental animal models and may be an alternative to human islet transplantation. We have…”
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A model for determining an effective in vivo dose of transplanted islets based on in vitro insulin secretion by Holdcraft, Robert W., Dumpala, Pradeep R., Smith, Barry H., Gazda, Lawrence S.

“…Background Allogeneic islet transplantation for the treatment of type 1 diabetes often requires multiple implant procedures, from as many as several human…”
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The use of pancreas biopsy scoring provides reliable porcine islet yields while encapsulation permits the determination of microbiological safety by Gazda, Lawrence S, Adkins, Hollie, Bailie, Johannah A, Byrd, Wendy, Circle, Lisa, Conn, Bryan, Diehl, Carolyn H, Hall, Richard D, Rubin, Albert L, Smith, Barry H

“…For clinical xenogenic islet transplantation to be successful, several requirements must be met. Among them is a sizeable and reliable source of fully…”
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Three-Dimensional Culture of Mouse Renal Carcinoma Cells in Agarose Macrobeads Selects for a Subpopulation of Cells with Cancer Stem Cell or Cancer Progenitor Properties by SMITH, Barry H, GAZDA, Lawrence S, DAVID, Eric M, SUIZHEN QIU, CORDON-CARDO, Carlos, HALL, Richard D, GORDON, Bruce R, DIEHL, Carolyn H, STENZEL, Kurt H, RUBIN, Albert L, CONN, Bryan L, JAIN, Kanti, ASINA, Shirin, LEVINE, Daniel M, PARKER, Thomas S, LARAMORE, Melissa A, MARTIS, Prithy C, VINEREAN, Horatiu V

“…The culture of tumor cell lines in three-dimensional scaffolds is considered to more closely replicate the in vivo tumor microenvironment than the standard…”
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Treatment of agarose-agarose RENCA macrobeads with docetaxel selects for OCT4+ cells with tumor-initiating capability by Gazda, Lawrence S, Martis, Prithy C, Laramore, Melissa A, Bautista, Melissa A, Dudley, Atira, Vinerean, Horatiu V, Smith, Barry H

“…The cancer stem cell (CSC) theory depicts such cells as having the capacity to produce both identical CSCs (symmetrical division) and tumor-amplifying daughter…”
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