Search Results - "Gayoso, Adam"
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Interpretable factor models of single-cell RNA-seq via variational autoencoders
Published in Bioinformatics (01-06-2020)“…Abstract Motivation Single-cell RNA-seq makes possible the investigation of variability in gene expression among cells, and dependence of variation on cell…”
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Joint probabilistic modeling of single-cell multi-omic data with totalVI
Published in Nature methods (01-03-2021)“…The paired measurement of RNA and surface proteins in single cells with cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) is a…”
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3
Cell2location maps fine-grained cell types in spatial transcriptomics
Published in Nature biotechnology (01-05-2022)“…Spatial transcriptomic technologies promise to resolve cellular wiring diagrams of tissues in health and disease, but comprehensive mapping of cell types in…”
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Characterization of cell fate probabilities in single-cell data with Palantir
Published in Nature biotechnology (01-04-2019)“…Single-cell RNA sequencing studies of differentiating systems have raised fundamental questions regarding the discrete versus continuous nature of both…”
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Mapping single-cell data to reference atlases by transfer learning
Published in Nature biotechnology (01-01-2022)“…Large single-cell atlases are now routinely generated to serve as references for analysis of smaller-scale studies. Yet learning from reference data is…”
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Enhancing scientific discoveries in molecular biology with deep generative models
Published in Molecular systems biology (01-09-2020)“…Generative models provide a well‐established statistical framework for evaluating uncertainty and deriving conclusions from large data sets especially in the…”
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A Python library for probabilistic analysis of single-cell omics data
Published in Nature biotechnology (01-02-2022)Get full text
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8
Stress-Adaptive Responses Associated with High-Level Carbapenem Resistance in KPC-Producing Klebsiella pneumoniae
Published in Journal of pathogens (01-01-2018)“…Carbapenem-resistant Enterobacteriaceae (CRE) organisms have emerged to become a major global public health threat among antimicrobial resistant bacterial…”
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An empirical Bayes method for differential expression analysis of single cells with deep generative models
Published in Proceedings of the National Academy of Sciences - PNAS (23-05-2023)“…Detecting differentially expressed genes is important for characterizing subpopulations of cells. In scRNA-seq data, however, nuisance variation due to…”
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Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells
Published in Nature methods (01-01-2024)“…RNA velocity has been rapidly adopted to guide interpretation of transcriptional dynamics in snapshot single-cell data; however, current approaches for…”
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The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans
Published in Science (American Association for the Advancement of Science) (13-05-2022)“…Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the…”
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PeakVI: A deep generative model for single-cell chromatin accessibility analysis
Published in Cell reports methods (28-03-2022)“…Single-cell ATAC sequencing (scATAC-seq) is a powerful and increasingly popular technique to explore the regulatory landscape of heterogeneous cellular…”
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Author Correction: Characterization of cell fate probabilities in single-cell data with Palantir
Published in Nature biotechnology (01-10-2019)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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14
Cell types of origin of the cell-free transcriptome
Published in Nature biotechnology (01-06-2022)“…Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the…”
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15
Deep Generative Modeling for Single-Cell Omics Data
Published 01-01-2023“…Single-cell omics technologies have transformed our ability to take high-throughput measurements of the molecular contents of individual cells. Applications of…”
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Dissertation -
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The scverse project provides a computational ecosystem for single-cell omics data analysis
Published in Nature biotechnology (01-05-2023)Get full text
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Publisher Correction: Cell types of origin of the cell-free transcriptome
Published in Nature biotechnology (01-06-2022)Get full text
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The scverse project provides a computational ecosystem for single-cell omics data analysis
Published in Nature biotechnology (01-05-2023)Get full text
Journal Article