Search Results - "Gaynon, P S"

Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children's Oncology Group Study AALL0031 by Schultz, K R, Carroll, A, Heerema, N A, Bowman, W P, Aledo, A, Slayton, W B, Sather, H, Devidas, M, Zheng, H W, Davies, S M, Gaynon, P S, Trigg, M, Rutledge, R, Jorstad, D, Winick, N, Borowitz, M J, Hunger, S P, Carroll, W L, Camitta, B

“…We previously reported preliminary findings that post induction imatinib mesylate (340 mg/m 2 /day), in combination with intensive chemotherapy, resulted in…”
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Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study by Nguyen, K, Devidas, M, Cheng, S-C, La, M, Raetz, E A, Carroll, W L, Winick, N J, Hunger, S P, Gaynon, P S, Loh, M L

“…Despite great progress in curing childhood acute lymphoblastic leukemia (ALL), survival after relapse remains poor. We analyzed survival after relapse among…”
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Philadelphia chromosome-negative very high-risk acute lymphoblastic leukemia in children and adolescents: results from Children’s Oncology Group Study AALL0031 by Schultz, K R, Devidas, M, Bowman, W P, Aledo, A, Slayton, W B, Sather, H, Zheng, H W, Davies, S M, Gaynon, P S, Trigg, M, Rutledge, R, Jorstad, D, Carroll, A J, Heerema, N, Winick, N, Borowitz, M J, Hunger, S P, Carroll, W L, Camitta, B

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Children's Cancer Group trials in childhood acute lymphoblastic leukemia : 1983-1995 by GAYNON, P. S, TRIGG, M. E, HEEREMA, N. A, SENSEL, M. G, SATHER, H. N, HAMMOND, G. D, BLEYER, W. A

“…Since 1968, the Children's Cancer Group (CCG) has treated more than 16,000 children with acute lymphoblastic leukemia (ALL). Herein, we report improvements…”
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High concordance from independent studies by the Children's Cancer Group (CCG) and Pediatric Oncology Group (POG) associating favorable prognosis with combined trisomies 4, 10, and 17 in children with NCI Standard-Risk B-precursor Acute Lymphoblastic Leukemia: a Children's Oncology Group (COG) initiative by SUTCLIFFE, M. J, SHUSTER, J. J, SATHER, H. N, CAMITTA, B. M, PULLEN, J, SCHULTZ, K. R, BOROWITZ, M. J, GAYNON, P. S, CARROLL, A. J, HEEREMA, N. A

“…Chromosome aberrations have a major role in pediatric acute lymphoblastic leukemia (ALL) risk assignment. The Children's Cancer Group (CCG) and the Pediatric…”
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Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements by PUI, C-H, CHESSELLS, J. M, HARHOTT, J, HARMS, D. O, HARRISON, C. J, HARRISON, P. L, HEEREMA, N, JANKA-SCHAUB, G, KAMPS, W, MASERA, G, PULLEN, J, RAIMONDI, S. C, CAMITTA, B, RICHARDS, S, RIEHM, H, SALLAN, S, SATHER, H, SHUSTER, J, SILVERMAN, L. B, VALSECCHI, M. G, VILMER, E, ZHOU, Y, GAYNON, P. S, BARUCHEL, A, SCHRAPPE, M, BIONDI, A, BOYETT, J. M, CARROLL, A, EDEN, O. B, EVANS, W. E, GADNER, H

“…To assess the clinical heterogeneity among patients with acute lymphoblastic leukemia (ALL) and various 11q23 abnormalities, we analyzed data on 497 infants,…”
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Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group by HEEREMA, N. A, NACHMAN, J. B, SATHER, H. N, LA, M. K, HUTCHINSON, R, LANGE, B. J, BOSTROM, B, STEINHERZ, P. G, GAYNON, P. S, UCKUN, F. M

“…Monosomy 7 or deletions of 7q are associated with many myeloid disorders; however, the significance of such abnormalities in childhood acute lymphoblastic…”
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Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome by HEEREMA, N. A, HARBOTT, J, AUCLERC, M-F, CARROLL, A. J, CONTER, V, HARRISON, C. J, PULLEN, J, RAIMONDI, S. C, RICHARDS, S, RIEHM, H, SATHER, H. N, SHUSTER, J. J, GALIMBERTI, S, SILVERMAN, L. B, VALSECCHI, M. G, ARICO, M, CAMITTA, B. M, GAYNON, P. S, JANKA-SCHAUB, G, KAMPS, W, BASSO, G, PUI, C-H, SCHRAPPE, M

“…Additional chromosomal aberrations occur frequently in Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) of childhood. The treatment…”
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Augmented Post-Induction Therapy for Children with High-Risk Acute Lymphoblastic Leukemia and a Slow Response to Initial Therapy by Nachman, James B, Sather, Harland N, Sensel, Martha G, Trigg, Michael E, Cherlow, Joel M, Lukens, John N, Wolff, Lawrence, Uckun, Fatih M, Gaynon, Paul S

“…In children with acute lymphoblastic leukemia (ALL) who are older than one year of age, certain presenting features, such as a white-cell count above 50,000…”
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Long-term results of the children's cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: A Children's Oncology Group Report by Gaynon, P S, Angiolillo, A L, Carroll, W L, Nachman, J B, Trigg, M E, Sather, H N, Hunger, S P, Devidas, M

“…The Children's Cancer Group enrolled 13 298 young people age <21 years on 1 of 16 protocols between 1983 and 2002. Outcomes were examined in three time…”
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Hypodiploidy With Less Than 45 Chromosomes Confers Adverse Risk in Childhood Acute Lymphoblastic Leukemia: A Report From the Children's Cancer Group by Heerema, Nyla A., Nachman, James B., Sather, Harland N., Sensel, Martha G., Lee, Mei K., Hutchinson, Raymond, Lange, Beverly J., Steinherz, Peter G., Bostrom, Bruce, Gaynon, Paul S., Uckun, Fatih

“…We have determined the prognostic significance of hypodiploidy (<46 chromosomes) in a large cohort of children with acute lymphoblastic leukemia (ALL) treated…”
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Cytoreduction and prognosis in acute lymphoblastic leukemia--the importance of early marrow response: report from the Childrens Cancer Group by Steinherz, P G, Gaynon, P S, Breneman, J C, Cherlow, J M, Grossman, N J, Kersey, J H, Johnstone, H S, Sather, H N, Trigg, M E, Chappell, R, Hammond, D, Bleyer, W A

“…To quantify the residual marrow lymphoblast fraction that best defines patients at high risk for relapse, and the optimal time for assessment during remission…”
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Survival after relapse in childhood acute lymphoblastic leukemia: Impact of site and time to first relapse: the Children's Cancer Group Experience by GAYNON, P. S, QU, R. P, CHAPPELL, R. J, WILLOUGHBY, M. L. N, TUBERGEN, D. G, STEINHERZ, P. G, TRIGG, M. E

“…Childhood acute lymphoblastic leukemia is the single most common childhood malignancy. Despite substantial improvements in therapy, cases in which relapse…”
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Augmented Berlin-Frankfurt-Munster therapy abrogates the adverse prognostic significance of slow early response to induction chemotherapy for children and adolescents with acute lymphoblastic leukemia and unfavorable presenting features: a report from the Children's Cancer Group by Nachman, J, Sather, H N, Gaynon, P S, Lukens, J N, Wolff, L, Trigg, M E

“…Compared with previous Children's Cancer Group (CCG) acute lymphoblastic leukemia (ALL) trials, therapy based on the Berlin-Frankfurt-Munster (BFM) 76 trial…”
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Response of children with high-risk acute lymphoblastic leukemia treated with and without cranial irradiation: a report from the Children's Cancer Group by Nachman, J, Sather, H N, Cherlow, J M, Sensel, M G, Gaynon, P S, Lukens, J N, Wolff, L, Trigg, M E

“…Intensified intrathecal (i.t.) chemotherapy without cranial radiation therapy (CRT) prevents CNS relapse in children with low-risk and intermediate-risk acute…”
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Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group by Uckun, F M, Sensel, M G, Sather, H N, Gaynon, P S, Arthur, D C, Lange, B J, Steinherz, P G, Kraft, P, Hutchinson, R, Nachman, J B, Reaman, G H, Heerema, N A

“…The nonrandom translocation t(1;19) has been associated with poor outcome in pediatric B-lineage acute lymphoblastic leukemia (ALL). Because most patients…”
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Early response to therapy and outcome in childhood acute lymphoblastic leukemia a review by GAYNON, P. S, DESAI, A. A, TUBERGEN, D. G, UCKUN, F. M, BOSTROM, B. C, HUTCHINSON, R. J, LANGE, B. J, NACHMAN, J. B, REAMAN, G. H, SATHER, H. N, STEINHERZ, P. G, TRIGG, M. E

“…Early response to therapy is defined as the initial response prior to Day 28 of treatment, the conventional time of marrow evaluation. The number of reports…”
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Prognostic Impact of Trisomies of Chromosomes 10, 17, and 5 Among Children With Acute Lymphoblastic Leukemia and High Hyperdiploidy (> 50 Chromosomes) by HEEREMA, N. A, SATHER, H. N, GAYNON, P. S, UCKUN, F. M, SENSEL, M. G, ZHANG, T, HUTCHINSON, R. J, NACHMAN, J. B, LANGE, B. J, STEINHERZ, P. G, BOSTROM, B. C, REAMAN, G. H

“…Children with acute lymphoblastic leukemia (ALL) and high hyperdiploidy (> 50 chromosomes) have improved outcome compared with other ALL patients. We sought to…”
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Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group by Heerema, N A, Sather, H N, Sensel, M G, Kraft, P, Nachman, J B, Steinherz, P G, Lange, B J, Hutchinson, R S, Reaman, G H, Trigg, M E, Arthur, D C, Gaynon, P S, Uckun, F M

“…Nonrandom chromosomal translocations are frequently observed in pediatric patients with acute lymphoblastic leukemia (ALL). Specific translocations, such as…”
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No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities by MOORMAN, A. V, RAIMONDI, S. C, HEEREMA, N, PIETERS, R, SCHRAPPE, M, SILVERMAN, L. B, VILMER, E, HARRISON, C. J, PUI, C-H, BARUCHEL, A, BIONDI, A, CARROLL, A. J, FORESTIER, E, GAYNON, P. S, HARBOTT, J, HARMS, D. O

“…This study characterized the additional chromosomal abnormalities (ACA) associated with 11q23 rearrangements in 450 infants and children with acute…”
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